NLR functions beyond pathogen recognition

Danger Signaling through the Inflammasome Acts as a Master Switch between Tolerance and Sensitization

(2014) Hideki Watanabe et al.   JOURNAL OF IMMUNOLOGY

Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation

(2010) Y. Nguyen et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

(2010) Jun Cui et al.   CELL

Control of infection by pyroptosis and autophagy: role of TLR and NLR

(2010) Karina R. Bortoluci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nod-like receptors: sentinels at host membranes

(2010) Dana J Philpott et al.   CURRENT OPINION IN IMMUNOLOGY

NB-LRR proteins: pairs, pieces, perception, partners, and pathways

(2010) Timothy K Eitas et al.   CURRENT OPINION IN PLANT BIOLOGY

Targeting IL-1β in disease; the expanding role of NLRP3 inflammasome

(2010) Ioannis Mitroulis et al.   European Journal of Internal Medicine

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

Nucleotide-Binding Oligomerization Domain-2 Inhibits Toll-Like Receptor-4 Signaling in the Intestinal Epithelium

(2010) Ward M. Richardson et al.   GASTROENTEROLOGY

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

A coding variant in NLRP1 is associated with autoimmune Addison's disease

(2010) Magdalena Żurawek et al.   HUMAN IMMUNOLOGY

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice

(2010) M. Lech et al.   INTERNATIONAL IMMUNOLOGY

A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses

(2010) Andreas Neerincx et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation

(2010) M. H. Zaki et al.   JOURNAL OF IMMUNOLOGY

Anti-Inflammatory Activity of PYNOD and Its Mechanism in Humans and Mice

(2010) R. Imamura et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Limits the Activation of Inflammatory Pathways

(2010) S. Benko et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NLRP12 Controls Dendritic and Myeloid Cell Migration To Affect Contact Hypersensitivity

(2010) J. C. Arthur et al.   JOURNAL OF IMMUNOLOGY

The Nucleotide-Binding Oligomerization Domain-Like Receptor NLRC5 Is Involved in IFN-Dependent Antiviral Immune Responses

(2010) Sven Kuenzel et al.   JOURNAL OF IMMUNOLOGY

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

(2010) T. B. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How the Noninflammasome NLRs Function in the Innate Immune System

(2010) J. P. Y. Ting et al.   SCIENCE

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors

(2009) O. Penack et al.   BLOOD

Evolution and functional divergence of NLRP genes in mammalian reproductive systems

(2009) Xin Tian et al.   BMC EVOLUTIONARY BIOLOGY

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

(2009) Mathieu J.M. Bertrand et al.   IMMUNITY

An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

(2009) D. Arnoult et al.   JOURNAL OF CELL SCIENCE

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NOD2 regulates hematopoietic cell function during graft-versus-host disease

(2009) Olaf Penack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity

(2009) A. S. McKee et al.   JOURNAL OF IMMUNOLOGY

MATER protein as substrate of PKC  in human cumulus cells

(2009) T. Maraldi et al.   MOLECULAR HUMAN REPRODUCTION

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

(2009) Greta Guarda et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Nuclear Pore Complex Component MOS7/Nup88 Is Required for Innate Immunity and Nuclear Accumulation of Defense Regulators in Arabidopsis

(2009) Y. T. Cheng et al.   PLANT CELL

Nod2 is required for the regulation of commensal microbiota in the intestine

(2009) T. Petnicki-Ocwieja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XIAP mediates NOD signaling via interaction with RIP2

(2009) A. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histogenomics: Association of Gene Expression Patterns With Histological Parameters in Kidney Biopsies

(2009) Paul Perco et al.   TRANSPLANTATION

Germline Mutation in NLRP2 (NALP2) in a Familial Imprinting Disorder (Beckwith-Wiedemann Syndrome)

(2009) Esther Meyer et al.   PLoS Genetics

Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation

(2008) M. Granell et al.   BLOOD

Caspase-12 Modulates NOD Signaling and Regulates Antimicrobial Peptide Production and Mucosal Immunity

(2008) Philippe M. LeBlanc et al.   Cell Host & Microbe

Bacterial Peptidoglycan Triggers Candida albicans Hyphal Growth by Directly Activating the Adenylyl Cyclase Cyr1p

(2008) Xiao-Li Xu et al.   Cell Host & Microbe

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

(2008) Ivan Tattoli et al.   EMBO REPORTS

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes

(2008) N F Magitta et al.   GENES AND IMMUNITY

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells – how diverse signals regulate suppression

(2008) Bin Li et al.   IMMUNOLOGY

Toll-Like Receptor 2 and NALP2 Mediate Induction of Human Beta-Defensins by Fusobacterium nucleatum in Gingival Epithelial Cells

(2008) S. Ji et al.   INFECTION AND IMMUNITY

Signal transduction pathways used by NLR-type innate immune receptors

(2008) Thomas A. Kufer   Molecular BioSystems

Nuclear Trafficking During Plant Innate Immunity

(2008) Jun Liu et al.   Molecular Plant

Identification of oocyte-selectiveNLRPgenes in rhesus macaque monkeys (Macaca mulatta)

(2008) Patrick McDaniel et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

The Nod-Like Receptor (NLR) Family: A Tale of Similarities and Differences

(2008) Martina Proell et al.   PLoS One

Expression Analysis of the NLRP Gene Family Suggests a Role in Human Preimplantation Development

(2008) Pu Zhang et al.   PLoS One

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in NALP12 cause hereditary periodic fever syndromes

(2008) I. Jeru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of adaptive immunity by different adjuvant–antigen combinations in mice lacking Nod2

(2008) Lilian O. Moreira et al.   VACCINE