The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis

DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization

(2015) Miroslav Brecik et al.   ACS Chemical Biology

Mycobacterium tuberculosis Gyrase Inhibitors as a New Class of Antitubercular Drugs

(2015) Delia Blanco et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Complex Mechanism of Antimycobacterial Action of 5-Fluorouracil

(2015) Vinayak Singh et al.   CHEMISTRY & BIOLOGY

Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis

(2015) Sae Woong Park et al.   CHEMISTRY & BIOLOGY

Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis

(2015) Rodney Dawson et al.   LANCET

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Direct inhibitors of InhA are active against Mycobacterium tuberculosis

(2015) U. H. Manjunatha et al.   Science Translational Medicine

Deficiency of the Novel Exopolyphosphatase Rv1026/PPX2 Leads to Metabolic Downshift and Altered Cell Wall Permeability in Mycobacterium tuberculosis

(2015) Yu-Min Chuang et al.   mBio

Gene silencing by CRISPR interference in mycobacteria

(2015) Eira Choudhary et al.   Nature Communications

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

(2015) Norman Moullan et al.   Cell Reports

Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline

(2015) L. Preiss et al.   Science Advances

Assessment of Mycobacterium tuberculosis Pantothenate Kinase Vulnerability through Target Knockdown and Mechanistically Diverse Inhibitors

(2014) B. K. Kishore Reddy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development

(2014) Wessel J.A. Moolman et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase

(2014) Zhixiang Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting Bacterial Central Metabolism for Drug Development

(2014) Paul Murima et al.   CHEMISTRY & BIOLOGY

Assessing essentiality of transketolase inMycobacterium tuberculosisusing an inducible protein degradation system

(2014) Gaëlle S. Kolly et al.   FEMS MICROBIOLOGY LETTERS

Conditional silencing of topoisomerase I gene ofMycobacterium tuberculosisvalidates its essentiality for cell survival

(2014) Wareed Ahmed et al.   FEMS MICROBIOLOGY LETTERS

Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents

(2014) Suresh B. Lakshminarayana et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo

(2014) F. Boldrin et al.   JOURNAL OF BACTERIOLOGY

Assessing the essentiality of the decaprenyl-phospho-d-arabinofuranose pathway inMycobacterium tuberculosisusing conditional mutants

(2014) Gaëlle S. Kolly et al.   MOLECULAR MICROBIOLOGY

Regulation of the ahpC Gene Encoding Alkyl Hydroperoxide Reductase in Mycobacterium smegmatis

(2014) Ha-Na Lee et al.   PLoS One

Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria

(2014) I. A. Rodionova et al.   mBio

Triosephosphate Isomerase Is Dispensable In Vitro yet Essential for Mycobacterium tuberculosis To Establish Infection

(2014) C. Trujillo et al.   mBio

Opposing effects of target overexpression reveal drug mechanisms

(2014) Adam C. Palmer et al.   Nature Communications

Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis

(2014) Susan Puckett et al.   PLoS Pathogens

The Normalcy of Dormancy: Common Themes in Microbial Quiescence

(2013) Emily S.C. Rittershaus et al.   Cell Host & Microbe

13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis

(2013) Dany J.V. Beste et al.   CHEMISTRY & BIOLOGY

Essential Roles for Mycobacterium tuberculosis Rel beyond the Production of (p)ppGpp

(2013) L. A. Weiss et al.   JOURNAL OF BACTERIOLOGY

Structural and Biochemical Characterization of Compounds InhibitingMycobacterium tuberculosisPantothenate Kinase

(2013) Christofer Björkelid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LC–MS based assay to measure intracellular compound levels in Mycobacterium smegmatis : Linking compound levels to cellular potency

(2013) Jyothi Bhat et al.   JOURNAL OF MICROBIOLOGICAL METHODS

GarA is an essential regulator of metabolism inMycobacterium tuberculosis

(2013) Marcello Ventura et al.   MOLECULAR MICROBIOLOGY

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

Advances in the development of new tuberculosis drugs and treatment regimens

(2013) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

(2013) Katherine A. Abrahams et al.   PLoS One

A High-Throughput Screen against Pantothenate Synthetase (PanC) Identifies 3-Biphenyl-4-Cyanopyrrole-2-Carboxylic Acids as a New Class of Inhibitor with Activity against Mycobacterium tuberculosis

(2013) Anuradha Kumar et al.   PLoS One

A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

(2013) J.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of CarD, an essential mycobacterial transcription factor

(2013) D. B. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Approval of Novel TB Drug Celebrated--With Restraint

(2013) J. Cohen   SCIENCE

4′-Phosphopantetheinyl Transferase PptT, a New Drug Target Required for Mycobacterium tuberculosis Growth and Persistence In Vivo

(2013) Cécile Leblanc et al.   PLoS Pathogens

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

(2012) Sarah A. Stanley et al.   ACS Chemical Biology

A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis

(2012) Puiying A. Mak et al.   ACS Chemical Biology

Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations

(2012) Jennifer E. Griffin et al.   CHEMISTRY & BIOLOGY

Pathway-Selective Sensitization of Mycobacterium tuberculosis for Target-Based Whole-Cell Screening

(2012) Garth L. Abrahams et al.   CHEMISTRY & BIOLOGY

Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase

(2012) Inna V. Krieger et al.   CHEMISTRY & BIOLOGY

Towards a new tuberculosis drug: pyridomycin - nature's isoniazid

(2012) Ruben C. Hartkoorn et al.   EMBO Molecular Medicine

Inhibition of the Sole Type I Signal Peptidase of Mycobacterium tuberculosis Is Bactericidal under Replicating and Nonreplicating Conditions

(2012) J. Ollinger et al.   JOURNAL OF BACTERIOLOGY

The Dormancy Regulator DosR Controls Ribosome Stability in Hypoxic Mycobacteria

(2012) Andrej Trauner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delamanid for Multidrug-Resistant Pulmonary Tuberculosis

(2012) Maria Tarcela Gler et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-throughput Screening and Sensitized Bacteria Identify an M. tuberculosis Dihydrofolate Reductase Inhibitor with Whole Cell Activity

(2012) Anuradha Kumar et al.   PLoS One

A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria

(2012) C. L. Gee et al.   Science Signaling

Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection

(2012) Ravikiran M. Raju et al.   PLoS Pathogens

Pharmacokinetic Evaluation of the Penetration of Antituberculosis Agents in Rabbit Pulmonary Lesions

(2011) Maria C. Kjellsson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identifying Vulnerable Pathways in Mycobacterium tuberculosis by Using a Knockdown Approach

(2011) Paul Carroll et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus

(2011) John W. Phillips et al.   CHEMISTRY & BIOLOGY

New tuberculosis drugs on the horizon

(2011) Stewart T Cole et al.   CURRENT OPINION IN MICROBIOLOGY

Validation of the Essential ClpP Protease in Mycobacterium tuberculosis as a Novel Drug Target

(2011) J. Ollinger et al.   JOURNAL OF BACTERIOLOGY

Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis inMycobaterium tuberculosis

(2011) Ce Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

VapC Toxins from Mycobacterium tuberculosis Are Ribonucleases that Differentially Inhibit Growth and Are Neutralized by Cognate VapB Antitoxins

(2011) Bintou Ahmadou Ahidjo et al.   PLoS One

Depletion of antibiotic targets has widely varying effects on growth

(2011) J.-R. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluating the Sensitivity of Mycobacterium tuberculosis to Biotin Deprivation Using Regulated Gene Expression

(2011) Sae Woong Park et al.   PLoS Pathogens

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

Drug–target residence time: critical information for lead optimization

(2010) Hao Lu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Development of a repressible mycobacterial promoter system based on two transcriptional repressors

(2010) Francesca Boldrin et al.   NUCLEIC ACIDS RESEARCH

Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase

(2010) Jee-Hyun Kim et al.   NUCLEIC ACIDS RESEARCH

Simultaneous Analysis of Multiple Mycobacterium tuberculosis Knockdown Mutants In Vitro and In Vivo

(2010) Antje Blumenthal et al.   PLoS One

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

(2010) J. Marrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leads for antitubercular compounds from kinase inhibitor library screens

(2010) Sophie Magnet et al.   TUBERCULOSIS

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

(2010) Kevin Pethe et al.   Nature Communications

Application of Fragment Growing and Fragment Linking to the Discovery of Inhibitors ofMycobacterium tuberculosisPantothenate Synthetase

(2009) Alvin W. Hung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CarD Is an Essential Regulator of rRNA Transcription Required for Mycobacterium tuberculosis Persistence

(2009) Christina L. Stallings et al.   CELL

Pristinamycin-inducible gene regulation in mycobacteria

(2009) Francesca Forti et al.   JOURNAL OF BIOTECHNOLOGY

A replication clock for Mycobacterium tuberculosis

(2009) Wendy P Gill et al.   NATURE MEDICINE

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

(2009) Nicolas Willand et al.   NATURE MEDICINE

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

(2009) Clifton E. Barry et al.   NATURE REVIEWS MICROBIOLOGY

Improved tetracycline repressors for gene silencing in mycobacteria

(2009) Marcus Klotzsche et al.   NUCLEIC ACIDS RESEARCH

The Genetic Requirements for Fast and Slow Growth in Mycobacteria

(2009) Dany J. V. Beste et al.   PLoS One

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

(2009) V. Makarov et al.   SCIENCE

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

(2009) Thierry Christophe et al.   PLoS Pathogens

Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death

(2008) Michael A. Kohanski et al.   CELL

Inhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction Intermediate

(2008) Alessio Ciulli et al.   CHEMBIOCHEM

Biosynthesis of D-arabinose in mycobacteria - a novel bacterial pathway with implications for antimycobacterial therapy

(2008) Beata A. Wolucka   FEBS Journal

Biosynthesis and Recycling of Nicotinamide Cofactors inMycobacterium tuberculosis

(2008) Helena I. M. Boshoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inducible protein degradation inBacillus subtilisusing heterologous peptide tags and adaptor proteins to target substrates to the protease ClpXP

(2008) Kevin L. Griffith et al.   MOLECULAR MICROBIOLOGY

Nitrile-inducible gene expression in mycobacteria

(2008) Amit K. Pandey et al.   TUBERCULOSIS