Advances in the development of new tuberculosis drugs and treatment regimens
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Title
Advances in the development of new tuberculosis drugs and treatment regimens
Authors
Keywords
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Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 12, Issue 5, Pages 388-404
Publisher
Springer Nature
Online
2013-04-30
DOI
10.1038/nrd4001
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Note: Only part of the references are listed.- Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test
- (2013) Stephen D Lawn et al. LANCET INFECTIOUS DISEASES
- Tuberculosis biomarkers discovery: developments, needs, and challenges
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- (2013) Alimuddin Zumla et al. NEW ENGLAND JOURNAL OF MEDICINE
- Approval of Novel TB Drug Celebrated--With Restraint
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- Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening
- (2012) Sarah A. Stanley et al. ACS Chemical Biology
- In VitroCombination Studies of Benzothiazinone Lead Compound BTZ043 against Mycobacterium tuberculosis
- (2012) Benoit Lechartier et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Inhaled Microparticles Containing Clofazimine Are Efficacious in Treatment of Experimental Tuberculosis in Mice
- (2012) R. K. Verma et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis
- (2012) Kapil Tahlan et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2012) L. E. Lim et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Variations of Subunit ε of the Mycobacterium tuberculosis F1FoATP Synthase and a Novel Model for Mechanism of Action of the Tuberculosis Drug TMC207
- (2012) Goran Biuković et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structure-Activity Relationships among the Kanamycin Aminoglycosides: Role of Ring I Hydroxyl and Amino Groups
- (2012) Sumantha Salian et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Phase II Dose-Ranging Trial of the Early Bactericidal Activity of PA-824
- (2012) Andreas H. Diacon et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis
- (2012) Ming Zhang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections
- (2012) David M. Tobin et al. CELL
- Old Drugs, New Purpose: Retooling Existing Drugs for Optimized Treatment of Resistant Tuberculosis
- (2012) K. E. Dooley et al. CLINICAL INFECTIOUS DISEASES
- Modelling tuberculosis trends in the USA
- (2012) A. N. HILL et al. EPIDEMIOLOGY AND INFECTION
- Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis
- (2012) Giovanni Sotgiu et al. EUROPEAN RESPIRATORY JOURNAL
- Outcomes of clofazimine for the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis
- (2012) Teesta Dey et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis
- (2012) F. A. Sirgel et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Abelson Tyrosine Kinase Controls Phagosomal Acidification Required for Killing of Mycobacterium tuberculosis in Human Macrophages
- (2012) H. Bruns et al. JOURNAL OF IMMUNOLOGY
- Adjunct Immunotherapies for Tuberculosis
- (2012) M. Uhlin et al. JOURNAL OF INFECTIOUS DISEASES
- Tuberculosis Diagnostics and Biomarkers: Needs, Challenges, Recent Advances, and Opportunities
- (2012) Ruth McNerney et al. JOURNAL OF INFECTIOUS DISEASES
- Innovative Trial Designs Are Practical Solutions for Improving the Treatment of Tuberculosis
- (2012) Patrick P. J. Phillips et al. JOURNAL OF INFECTIOUS DISEASES
- 14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial
- (2012) Andreas H Diacon et al. LANCET
- Scaling up interventions to achieve global tuberculosis control: progress and new developments
- (2012) Mario Raviglione et al. LANCET
- Meropenem inhibits D,D-carboxypeptidase activity inMycobacterium tuberculosis
- (2012) Pradeep Kumar et al. MOLECULAR MICROBIOLOGY
- Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
- (2012) Anna E Grzegorzewicz et al. Nature Chemical Biology
- Delamanid for Multidrug-Resistant Pulmonary Tuberculosis
- (2012) Maria Tarcela Gler et al. NEW ENGLAND JOURNAL OF MEDICINE
- Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis
- (2012) Myungsun Lee et al. NEW ENGLAND JOURNAL OF MEDICINE
- Successful Shortening of Tuberculosis Treatment Using Adjuvant Host-Directed Therapy with FDA-Approved Phosphodiesterase Inhibitors in the Mouse Model
- (2012) Mamoudou Maiga et al. PLoS One
- Rapid Evaluation in Whole Blood Culture of Regimens for XDR-TB Containing PNU-100480 (Sutezolid), TMC207, PA-824, SQ109, and Pyrazinamide
- (2012) Robert S. Wallis et al. PLoS One
- Adjunctive TNF Inhibition with Standard Treatment Enhances Bacterial Clearance in a Murine Model of Necrotic TB Granulomas
- (2012) Ciaran Skerry et al. PLoS One
- Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques
- (2012) P. L. Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
- (2012) S. M. Batt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis
- (2012) S. Chakraborty et al. SCIENCE
- Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis
- (2012) J. Neres et al. Science Translational Medicine
- A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: design issues and lessons learnt from the Gatifloxacin for TB (OFLOTUB) project
- (2012) Corinne SC Merle et al. Trials
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- (2011) Stewart T Cole et al. CURRENT OPINION IN MICROBIOLOGY
- WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update
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- The challenge of new drug discovery for tuberculosis
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- Meropenem/Clavulanate and Linezolid Treatment for Extensively Drug-resistant Tuberculosis
- (2011) Nicolas Dauby et al. PEDIATRIC INFECTIOUS DISEASE JOURNAL
- Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis
- (2011) W. Shi et al. SCIENCE
- Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs
- (2011) Selvakumar Subbian et al. PLoS Pathogens
- Short, Highly Effective, and Inexpensive Standardized Treatment of Multidrug-resistant Tuberculosis
- (2010) Armand Van Deun et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Structure of theMycobacterium tuberculosisd-Alanine:d-Alanine Ligase, a Target of the Antituberculosis Drug d-Cycloserine
- (2010) John B. Bruning et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Clinical Isolates of Mycobacterium tuberculosis in Four European Hospitals Are Uniformly Susceptible to Benzothiazinones
- (2010) M. R. Pasca et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vitro Interactions between New Antitubercular Drug Candidates SQ109 and TMC207
- (2010) V. M. Reddy et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Biomarker-Assisted Dose Selection for Safety and Efficacy in Early Development of PNU-100480 for Tuberculosis
- (2010) Robert S. Wallis et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Treatment Outcomes among Patients with Extensively Drug‐Resistant Tuberculosis: Systematic Review and Meta‐Analysis
- (2010) Karen R. Jacobson et al. CLINICAL INFECTIOUS DISEASES
- Pharmacokinetics and Whole‐Blood Bactericidal Activity againstMycobacterium tuberculosisof Single Doses of PNU‐100480 in Healthy Volunteers
- (2010) Robert S. Wallis et al. JOURNAL OF INFECTIOUS DISEASES
- Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 ofMycobacterium tuberculosis
- (2010) Claudia Trefzer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Global tuberculosis drug development pipeline: the need and the reality
- (2010) Zhenkun Ma et al. LANCET
- Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study
- (2010) Keertan Dheda et al. LANCET
- Sputum monitoring during tuberculosis treatment for predicting outcome: systematic review and meta-analysis
- (2010) David J Horne et al. LANCET INFECTIOUS DISEASES
- Leads for antitubercular compounds from kinase inhibitor library screens
- (2010) Sophie Magnet et al. TUBERCULOSIS
- Shortening Treatment in Adults with Noncavitary Tuberculosis and 2-Month Culture Conversion
- (2009) John L. Johnson et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Rates and Mechanisms of Resistance Development in Mycobacterium tuberculosis to a Novel Diarylquinoline ATP Synthase Inhibitor
- (2009) E. Huitric et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis
- (2009) Andreas H. Diacon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
- (2009) V. Makarov et al. SCIENCE
- Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis
- (2009) J.-E. Hugonnet et al. SCIENCE
- High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors
- (2009) Thierry Christophe et al. PLoS Pathogens
- A Once-Weekly R207910-containing Regimen Exceeds Activity of the Standard Daily Regimen in Murine Tuberculosis
- (2008) Nicolas Veziris et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Selectivity of TMC207 towards Mycobacterial ATP Synthase Compared with That towards the Eukaryotic Homologue
- (2008) A. C. Haagsma et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents
- (2008) J. G. Hurdle et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Diarylquinolines Are Bactericidal for Dormant Mycobacteria as a Result of Disturbed ATP Homeostasis
- (2008) Anil Koul et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prevention of Drug Carryover Effects in Studies Assessing Antimycobacterial Efficacy of TMC207
- (2008) N. Lounis et al. JOURNAL OF CLINICAL MICROBIOLOGY
- The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis
- (2008) S. P. S. Rao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
- (2008) R. Singh et al. SCIENCE
- Cycloserine
- (2008) TUBERCULOSIS
- The early bactericidal activity of anti-tuberculosis drugs: a literature review
- (2008) P.R. Donald et al. TUBERCULOSIS
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