Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria

Approval of Novel TB Drug Celebrated--With Restraint

(2013) J. Cohen   SCIENCE

Targeting InhA, the FASII Enoyl-ACP Reductase: SAR Studies on Novel Inhibitor Scaffolds

(2012) Pan Pan et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Quinolinate Salvage and Insights for Targeting NAD Biosynthesis in Group A Streptococci

(2012) L. Sorci et al.   JOURNAL OF BACTERIOLOGY

Glutamine versus Ammonia Utilization in the NAD Synthetase Family

(2012) Jessica De Ingeniis et al.   PLoS One

Potent Inhibitors of a Shikimate Pathway Enzyme fromMycobacterium tuberculosis

(2011) Sebastian Reichau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative Metabolic Flux Profiling of Melanoma Cell Lines

(2011) David A. Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of antibiotic targets has widely varying effects on growth

(2011) J.-R. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis

(2011) Hugues Ouellet et al.   TRENDS IN MICROBIOLOGY

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

Genomics-driven Reconstruction ofAcinetobacterNAD Metabolism

(2010) Leonardo Sorci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative genomics of NAD(P) biosynthesis and novel antibiotic drug targets

(2010) Jicai Bi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Complexes of Bacterial Nicotinate Mononucleotide Adenylyltransferase with Inhibitors: Implication for Structure-Based Drug Design and Improvement

(2010) Nian Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

NAD+auxotrophy is bacteriocidal for the tubercle bacilli

(2010) Catherine Vilchèze et al.   MOLECULAR MICROBIOLOGY

Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs)

(2009) Whitney Beysselance Moro et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting NAD Biosynthesis in Bacterial Pathogens: Structure-Based Development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD

(2009) Leonardo Sorci et al.   CHEMISTRY & BIOLOGY

SAR Studies for a New Class of Antibacterial NAD Biosynthesis Inhibitors

(2009) Whitney Beysselance Moro et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Regulation of active site coupling in glutamine-dependent NAD+ synthetase

(2009) Nicole LaRonde-LeBlanc et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition

(2009) M. S. Siegrist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis

(2009) L. Sorci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis and Recycling of Nicotinamide Cofactors inMycobacterium tuberculosis

(2008) Helena I. M. Boshoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

(2008) S. P. S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA