Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents

The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells

(2014) Véronique Dartois   NATURE REVIEWS MICROBIOLOGY

A medicinal chemists’ guide to the unique difficulties of lead optimization for tuberculosis

(2013) Véronique Dartois et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of Mycobacterium tuberculosis Whole Cell Screening Hits as Potential Antituberculosis Agents

(2013) Christopher B. Cooper   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides: A Promising Class of Antituberculosis Agents

(2013) Ravinder Reddy Kondreddi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Tetrahydropyrazolopyrimidine Carboxamide Derivatives As Potent and Orally Active Antitubercular Agents

(2013) Fumiaki Yokokawa et al.   ACS Medicinal Chemistry Letters

Meropenem-Clavulanic Acid Shows Activity against Mycobacterium tuberculosis In Vivo

(2012) Kathleen England et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis

(2012) Scott G. Franzblau et al.   TUBERCULOSIS

Pharmacokinetics and Pharmacodynamics of TMC207 and ItsN-Desmethyl Metabolite in a Murine Model of Tuberculosis

(2011) Marie-Claude Rouan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Totally Drug-Resistant Tuberculosis in India

(2011) Z. F. Udwadia et al.   CLINICAL INFECTIOUS DISEASES

The challenge of new drug discovery for tuberculosis

(2011) Anil Koul et al.   NATURE

PA-824 Exhibits Time-Dependent Activity in a Murine Model of Tuberculosis

(2010) Zahoor Ahmad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB

(2010) Pavan K Vaddady et al.   Future Medicinal Chemistry

High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery

(2010) Thierry Christophe et al.   Future Medicinal Chemistry

The Population Dynamics and Control of Tuberculosis

(2010) C. Dye et al.   SCIENCE

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

(2010) Kevin Pethe et al.   Nature Communications

Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability

(2009) M. Gengenbacher et al.   MICROBIOLOGY-SGM

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

(2009) J.-E. Hugonnet et al.   SCIENCE

Biopharmaceutics, Pharmacokinetics and Pharmacodynamics of Antituberculosis Drugs

(2008) Nageshwar Budha et al.   CURRENT MEDICINAL CHEMISTRY

Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis

(2008) M. Kurabachew et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

(2008) S. P. S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacokinetics and pharmacodynamics in the development of anti-tuberculosis drugs

(2008) G.R. Davies et al.   TUBERCULOSIS