Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis

Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation

(2015) M Bashashati et al.   BRITISH JOURNAL OF PHARMACOLOGY

N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis

(2015) Mireille Alhouayek et al.   FASEB JOURNAL

Endocannabinoid metabolism by cytochrome P450 monooxygenases

(2015) Susan Zelasko et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Targeting α- and β-Adrenergic Receptors Differentially Shifts Th1, Th2, and Inflammatory Cytokine Profiles in Immune Organs to Attenuate Adjuvant Arthritis

(2015) Cheri L. Lubahn et al.   Frontiers in Immunology

Role of adiponectin in the metabolic effects of cannabinoid type 1 receptor blockade in mice with diet-induced obesity

(2014) Joseph Tam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cannabinoids negatively modulate striatal glutamate and dopamine release and behavioural output of acute d-amphetamine

(2014) A. Polissidis et al.   BEHAVIOURAL BRAIN RESEARCH

Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis

(2014) Shin Fukuda et al.   BMC MUSCULOSKELETAL DISORDERS

Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent

(2014) Francesca Borrelli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids

(2014) Rebecca A. Kohnz et al.   CHEMICAL SOCIETY REVIEWS

Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands

(2014) Marco Fidaleo et al.   CURRENT MEDICINAL CHEMISTRY

Endocannabinoid-mediated retrograde modulation of synaptic transmission

(2014) Takako Ohno-Shosaku et al.   CURRENT OPINION IN NEUROBIOLOGY

Neurotrophins, endocannabinoids and thermo-transient receptor potential: a threesome in pain signalling

(2014) Isabel Devesa et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity

(2014) Mariëtte R. Boon et al.   FASEB JOURNAL

Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells

(2014) Xinying Jia et al.   FEBS LETTERS

TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective

(2014) Rainer H. Straub   JOURNAL OF MOLECULAR MEDICINE-JMM

Mutation of Putative GRK Phosphorylation Sites in the Cannabinoid Receptor 1 (CB1R) Confers Resistance to Cannabinoid Tolerance and Hypersensitivity to Cannabinoids in Mice

(2014) D. J. Morgan et al.   JOURNAL OF NEUROSCIENCE

Presynaptic Calcium Channel Inhibition Underlies CB1 Cannabinoid Receptor-Mediated Suppression of GABA Release

(2014) G. G. Szabo et al.   JOURNAL OF NEUROSCIENCE

Calcium entry via TRPV1 but not ASICs induces neuropeptide release from sensory neurons

(2014) Aurélien Boillat et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons

(2014) Z.-Y. Wang et al.   NEUROSCIENCE

Advances in the discovery of N-acylethanolamine acid amidase inhibitors

(2014) Tiziano Bandiera et al.   PHARMACOLOGICAL RESEARCH

Cardiovascular risk in rheumatoid arthritis: recent advances in the understanding of the pivotal role of inflammation, risk predictors and the impact of treatment

(2014) E. Choy et al.   RHEUMATOLOGY

What we know and do not know about the cannabinoid receptor 2 (CB2)

(2014) Anna Maria Malfitano et al.   SEMINARS IN IMMUNOLOGY

The sympathetic nervous response in inflammation

(2014) Georg Pongratz et al.   ARTHRITIS RESEARCH & THERAPY

New insights into the impact of neuro-inflammation in rheumatoid arthritis

(2014) Nicholas R. Fuggle et al.   Frontiers in Neuroscience

The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia

(2014) Pilar Sánchez-Blázquez et al.   Frontiers in Pharmacology

Ligand determinants of fatty acid activation of the pronociceptive ion channel TRPA1

(2014) William John Redmond et al.   PeerJ

Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats

(2013) Zeynep Mine Coskun et al.   ACTA HISTOCHEMICA

Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation

(2013) Marnie Duncan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

CB1 and CB2 Cannabinoid Receptor Agonists Induce Peripheral Antinociception by Activation of the Endogenous Noradrenergic System

(2013) Thiago R. L. Romero et al.   ANESTHESIA AND ANALGESIA

Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis

(2013) Zsuzsa Jenei-Lanzl et al.   ANNALS OF THE RHEUMATIC DISEASES

Neuronal α1/2-adrenergic stimulation of IFN-γ, IL-6, and CXCL-1 in murine spleen in late experimental arthritis

(2013) Thomas Meinel et al.   BRAIN BEHAVIOR AND IMMUNITY

The Effects of TNF α Antagonist Therapy on Bone Metabolism in Rheumatoid Arthritis: A Systematic Review

(2013) Rajalingham Sakthiswary et al.   CURRENT DRUG TARGETS

Diuretic effects of cannabinoid agonists in mice

(2013) Girish R. Chopda et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Blockade of cannabinoid receptors reduces inflammation, leukocyte accumulation and neovascularization in a model of sponge-induced inflammatory angiogenesis

(2013) Rodrigo Guabiraba et al.   INFLAMMATION RESEARCH

Carboxyl-terminal Domain of Transient Receptor Potential Vanilloid 1 Contains Distinct Segments Differentially Involved in Capsaicin- and Heat-induced Desensitization

(2013) John Joseph et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic potential of a novel cannabinoid agent CB52 in the mouse model of experimental autoimmune encephalomyelitis

(2013) R. Ribeiro et al.   NEUROSCIENCE

Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism

(2013) Katarzyna Starowicz et al.   PLoS One

The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysis

(2013) F. Matcham et al.   RHEUMATOLOGY

Role of neuroendocrine and neuroimmune mechanisms in chronic inflammatory rheumatic diseases—The 10-year update

(2013) Rainer H. Straub et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG

(2013) S Valdeolivas et al.   Cell Death & Disease

Expression and functions of μ-opioid receptors and cannabinoid receptors type 1 in T lymphocytes

(2012) Jürgen Kraus   Annals of the New York Academy of Sciences

Cortisol-mediated adhesion of synovial fibroblasts is dependent on the degradation of anandamide and activation of the endocannabinoid system

(2012) Torsten Lowin et al.   ARTHRITIS AND RHEUMATISM

Δ9-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice

(2012) Carol A. Paronis et al.   BEHAVIOURAL PHARMACOLOGY

PPARγ activation prevents impairments in spatial memory and neurogenesis following transient illness

(2012) Brandi K. Ormerod et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation and desensitization of TRPV1 channels in sensory neurons by the PPARα agonist palmitoylethanolamide

(2012) Paolo Ambrosino et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury

(2012) Y. Yang et al.   CELLULAR SIGNALLING

Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders

(2012) Cristoforo Silvestri et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Hypoxia-inducible Factor-1α (HIF1α) Switches on Transient Receptor Potential Ankyrin Repeat 1 (TRPA1) Gene Expression via a Hypoxia Response Element-like Motif to Modulate Cytokine Release

(2012) Noriyuki Hatano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)

(2012) Dina Navia-Paldanius et al.   JOURNAL OF LIPID RESEARCH

Role of peripheral nerve fibres in acute and chronic inflammation in arthritis

(2012) Georg Pongratz et al.   Nature Reviews Rheumatology

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

Off-Target Cannabinoid Effects Mediated by GPR55

(2012) Christopher M. Henstridge   PHARMACOLOGY

Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation

(2011) L. De Petrocellis et al.   Acta Physiologica

Endocannabinoid system dysfunction in mood and related disorders

(2011) C. H. Ashton et al.   ACTA PSYCHIATRICA SCANDINAVICA

The sympathetic nervous system stimulates anti-inflammatory B cells in collagen-type II-induced arthritis

(2011) Georg Pongratz et al.   ANNALS OF THE RHEUMATIC DISEASES

Nerve growth factor: A key local regulator in the pathogenesis of inflammatory arthritis

(2011) Siba P. Raychaudhuri et al.   ARTHRITIS AND RHEUMATISM

Increased density of sympathetic nerve fibers in metabolically activated fat tissue surrounding human synovium and mouse lymph nodes in arthritis

(2011) Rainer H. Straub et al.   ARTHRITIS AND RHEUMATISM

First appearance and location of catecholaminergic cells during experimental arthritis and elimination by chemical sympathectomy

(2011) Silvia Capellino et al.   ARTHRITIS AND RHEUMATISM

Sympathetic inhibition of IL-6, IFN-γ, and KC/CXCL1 and sympathetic stimulation of TGF-β in spleen of early arthritic mice

(2011) Rainer H. Straub et al.   BRAIN BEHAVIOR AND IMMUNITY

Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells

(2011) Douglas McHugh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Triphasic blood pressure responses to cannabinoids: do we understand the mechanism?

(2011) Barbara Malinowska et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bioactivation Pathways of the Cannabinoid Receptor 1 Antagonist Rimonabant

(2011) M. A. Bergstrom et al.   DRUG METABOLISM AND DISPOSITION

Cannabinoid 1 Receptor Blockade Reduces Atherosclerosis with Enhances Reverse Cholesterol Transport

(2011) Koichi Sugamura et al.   Journal of Atherosclerosis and Thrombosis

Inverse agonism of cannabinoid CB1 receptor blocks the adhesion of encephalitogenic T cells in inflamed brain venules by a protein kinase A-dependent mechanism

(2011) Barbara Rossi et al.   JOURNAL OF NEUROIMMUNOLOGY

Local Activation of Cannabinoid CB1 Receptors in the Urinary Bladder Reduces the Inflammation-Induced Sensitization of Bladder Afferents

(2011) Jean-Sébastien Walczak et al.   Molecular Pain

Inhibitory CB1 and activating/desensitizing TRPV1-mediated cannabinoid actions on CGRP release in rodent skin

(2011) Matthias A. Engel et al.   NEUROPEPTIDES

TRPV1, TRPA1, and CB1 in the isolated vagus nerve – Axonal chemosensitivity and control of neuropeptide release

(2011) K. Weller et al.   NEUROPEPTIDES

Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons

(2011) Mayur Patil et al.   NEUROPHARMACOLOGY

Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis

(2011) M.N. Hill et al.   NEUROSCIENCE

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Central Cannabinoid CB1 Receptor Is Required for Diet-Induced Obesity and Rimonabant's Antiobesity Effects in Mice

(2011) Zhen Pang et al.   Obesity

Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice

(2011) Steven G. Kinsey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

CB1 – Cannabinoid Receptor Antagonist Effects on Cortisol in Cannabis-Dependent Men

(2011) Robert S. Goodwin et al.   AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE

Insulin resistance in rheumatoid arthritis: the impact of the anti-TNF-α therapy

(2010) Miguel A. Gonzalez-Gay et al.   Annals of the New York Academy of Sciences

Effects of cannabinoids and cannabinoid-enrichedCannabisextracts on TRP channels and endocannabinoid metabolic enzymes

(2010) Luciano De Petrocellis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoids and Bone: Friend or Foe?

(2010) Aymen I. Idris et al.   CALCIFIED TISSUE INTERNATIONAL

Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity

(2010) Daniel Ursu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Review: Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases

(2010) R. H. Straub et al.   JOURNAL OF INTERNAL MEDICINE

Presynaptic CB1 Receptors Regulate Synaptic Plasticity at Cerebellar Parallel Fiber Synapses

(2010) Megan R. Carey et al.   JOURNAL OF NEUROPHYSIOLOGY

Thermally Active TRPV1 Tonically Drives Central Spontaneous Glutamate Release

(2010) K. Shoudai et al.   JOURNAL OF NEUROSCIENCE

Anti-Inflammatory Properties of CB1-Receptor Antagonist Involves  2 Adrenoceptors

(2010) S. J. Mnich et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

Differential effects of CB1 neutral antagonists and inverse agonists on gastrointestinal motility in mice

(2010) M. A. Storr et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Transient receptor potential V1 regulates activation and modulation of transient receptor potential A1 by Ca2+

(2010) M.J. Patil et al.   NEUROSCIENCE

Reversal of Inflammation-Induced Impairment of Glucose Uptake in Adipocytes by Direct Effect of CB1 Antagonism on Adipose Tissue Macrophages

(2010) Alexandra Miranville et al.   Obesity

A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of inflammatory and neuropathic pain

(2010) Xiao Hong Yu et al.   PAIN

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Rapid alteration of stress-induced hypothalamic–pituitary–adrenal hormone secretion in the rat: A comparison of glucocorticoids and cannabinoids

(2010) Abigail B. Ginsberg et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis

(2009) Alexander Fassold et al.   ARTHRITIS AND RHEUMATISM

Cannabinoid Receptor Type 1 Protects against Age- Related Osteoporosis by Regulating Osteoblast and Adipocyte Differentiation in Marrow Stromal Cells

(2009) Aymen I. Idris et al.   Cell Metabolism

Monoaminergic neurotransmission contributes to cannabinoid-induced activation of the hypothalamic-pituitary-adrenal axis

(2009) Ryan J. McLaughlin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

β2-adrenoceptor stimulation inhibits advanced glycation end products-induced adhesion molecule expression and cytokine production in human peripheral blood mononuclear cells

(2009) Hideo Kohka Takahashi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Expression and Function of Endocannabinoid Receptors in the Human Adrenal Cortex

(2009) C. G. Ziegler et al.   HORMONE AND METABOLIC RESEARCH

Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids

(2009) João P Pereira et al.   NATURE IMMUNOLOGY

Tumour necrosis factor α mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1β, protein kinase C and cyclooxygenase-2 signalling

(2009) Fiona A. Russell et al.   PAIN

The psychiatric side-effects of rimonabant

(2009) Fabrício A. Moreira et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Mode of action of cannabinoids on nociceptive nerve endings

(2009) Michaela Kress et al.   EXPERIMENTAL BRAIN RESEARCH

Disrupted brain-immune system-joint communication during experimental arthritis

(2008) Adriana del Rey et al.   ARTHRITIS AND RHEUMATISM

Neuronally released sympathetic neurotransmitters stimulate splenic interferon-γ secretion from T cells in early type II collagen-induced arthritis

(2008) Rainer H. Straub et al.   ARTHRITIS AND RHEUMATISM

An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells

(2008) Peter Härle et al.   ARTHRITIS AND RHEUMATISM

Fatty Acid Amide Hydrolase Inhibition Heightens Anandamide Signaling Without Producing Reinforcing Effects in Primates

(2008) Zuzana Justinova et al.   BIOLOGICAL PSYCHIATRY

Differences in the injury/sprouting response of splenic noradrenergic nerves in Lewis rats with adjuvant-induced arthritis compared with rats treated with 6-hydroxydopamine

(2008) Dianne Lorton et al.   BRAIN BEHAVIOR AND IMMUNITY

‘Entourage’ effects ofN-palmitoylethanolamide andN-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors

(2008) W-SV Ho et al.   BRITISH JOURNAL OF PHARMACOLOGY

SA13353 (1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea) inhibits TNF-α production through the activation of capsaicin-sensitive afferent neurons mediated via transient receptor potential vanilloid 1 in vivo

(2008) Masaaki Murai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cannabinoids Desensitize Capsaicin and Mustard Oil Responses in Sensory Neurons via TRPA1 Activation

(2008) A. N. Akopian et al.   JOURNAL OF NEUROSCIENCE

Unknown

(2008) Herbert Tilg et al.   MOLECULAR MEDICINE

The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System

(2008) Blerina Kola et al.   PLoS One

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences

(2007) J M McPartland et al.   BRITISH JOURNAL OF PHARMACOLOGY

The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling

(2007) Joseph Tam et al.   FASEB JOURNAL

Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling

(2007) Tanya L. Daigle et al.   NEUROPHARMACOLOGY

Some effects of CB1 antagonists with inverse agonist and neutral biochemical properties

(2007) Jack Bergman et al.   PHYSIOLOGY & BEHAVIOR