Article
Medicine, General & Internal
Elena Izkhakov, Yacov Shacham, Merav Serebro, Iris Yaish, Yonit Marcus, Gabi Shefer, Karen Tordjman, Yona Greenman, Naftali Stern, Tomer Ziv-Baran
Summary: This study examined the effect of monotherapy with the PSCK9 inhibitor evolocumab on high-risk cardiovascular patients, showing significant reductions in lipid profile and aldosterone levels after 3 months of treatment. The findings suggest that reductions in aldosterone secretion under evolocumab therapy may be associated with decreased cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sepideh Khaksar, Mona Salimi, Hadi Zeinoddini, Nima Naderi
Summary: This research investigated the involvement of CB1 and TRPV1 receptors in the protective effects of anandamide in epilepsy. The results showed that anandamide decreased seizure scores, while the TRPV1 and CB1 antagonists had no effect on seizure scores. Co-administration of the antagonists attenuated the protective effect of anandamide. Furthermore, anandamide led to a decrease in the expressions of CREB and p-CREB in hippocampal neurons.
NEUROCHEMICAL RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Katiuska Satue, Esterina Fazio, Ana Munoz, Pietro Medica
Summary: This study investigated the physiological mechanisms involved in electrolyte balance during the periovulatory period in cycling mares. The simultaneous increase in ACTH, CORT, and ALD prior to ovulation suggests the involvement of the adrenocortical pituitary axis in ovulatory mechanisms. It also found that the pituitary adrenocortical response and ALD may be involved in ovulatory mechanisms without a direct relation with electrolyte pattern.
Article
Pharmacology & Pharmacy
Stewart Ramsay, Nick J. Spencer, Vladimir Zagorodnyuk
Summary: The aim of this study is to determine the role of endocannabinoids, anandamide (AEA) and 2-arachidonolylglycerol (2-AG), in regulating mechanosensitivity of probable nociceptive neurons innervating the bladder - capsaicin-sensitive mucosal afferents. The results showed that AEA potentiated the mechanical response of mucosal afferents, while 2-AG inhibited their response. These findings have important implications for understanding the role of endocannabinoids in regulating bladder sensation and function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Christina Tatsi, Andrea G. Maria, Cole Malloy, Lin Lin, Edra London, Nick Settas, Chelsi Flippo, Meg Keil, Fady Hannah-Shmouni, Dax A. Hoffman, Constantine A. Stratakis
Summary: This study reports a case of a 10-year-old child with Cushing syndrome due to bilateral adrenocortical hyperplasia, involving the KCNJ5 gene, without identifiable gene defects. The results show that the KCNJ5 pathogenic variant affects the conductance of the Kir3.4 channel, differing from those causing primary aldosteronism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Peter Kolkhof, Amer Joseph, Ulrich Kintscher
Summary: Over the past 30 years, there has been significant progress in understanding the role of aldosterone and mineralocorticoid receptor in cardiovascular and kidney diseases. Ongoing research is focused on developing safer and more effective nonsteroidal MR antagonists.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Marie Obdrzalkova, Libor Ustohal, Natasa Hlavacova, Michaela Mayerova, Eva Ceskova, Tomas Kasparek, Daniela Jezova
Summary: This pilot study aimed to investigate whether dysregulation of neuroendocrine biomarker signaling pathways in the first episode of non-affective psychosis is a predictive factor of treatment outcome. The study revealed that lower baseline aldosterone and higher baseline cortisol concentrations may predict a more favorable treatment outcome for patients with the first episode of psychosis.
Article
Peripheral Vascular Disease
Yujiro Maeoka, Xiao-Tong Su, Wen-Hui Wang, Xin-Peng Duan, Avika Sharma, Na Li, Olivier Staub, James A. McCormick, David H. Ellison
Summary: The study suggests that MR is activated in the absence of aldosterone in DCT2 and partially CCD, indicating that glucocorticoid binding to MR may preserve sodium homeostasis in DCT2.
Review
Gastroenterology & Hepatology
Hailey Cuddihey, Wallace K. MacNaughton, Keith A. Sharkey
Summary: This review illustrates the role of the endocannabinoid system in regulating intestinal homeostasis, including the regulation of intestinal permeability, fluid secretion, and immune regulation. It also emphasizes the reciprocal regulation between the endocannabinoid system and the gut microbiome.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Endocrinology & Metabolism
Nada Younes, Isabelle Bourdeau, Andre Lacroix
Summary: Primary adrenal insufficiency is a rare but potentially fatal disease characterized by destruction of the adrenal cortex leading to hormone deficiencies. Patients often present with fatigue, weight loss, melanoderma, and hypotension. Diagnosis requires testing hormone levels and concentrations.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yoshimichi Takeda, Masashi Demura, Mitsuhiro Kometani, Shigehiro Karashima, Takashi Yoneda, Yoshiyu Takeda
Summary: Aldosterone and cortisol play important roles in cardiovascular diseases and metabolic disorders. Epigenetic mechanisms control the expression of steroid hormone synthase genes, including CYP11B2 and CYP11B1, through DNA methylation. Various factors, such as angiotensin II, potassium, and low-salt diet, can regulate the expression of these genes by inducing changes in DNA methylation levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chiara Sabbadin, Carlo Saccardi, Alessandra Andrisani, Amerigo Vitagliano, Loris Marin, Eugenio Ragazzi, Luciana Bordin, Guido Ambrosini, Decio Armanini
Summary: Endometriosis is a chronic inflammatory disease that is associated with pelvic pain, infertility, and increased cardiovascular risk. This study aimed to evaluate the levels of aldosterone and cortisol, as well as blood pressure values, in women with endometriosis. The results showed that there was increased biological aldosterone activity and dysregulation of the hypothalamic-pituitary-adrenal axis in early stages of endometriosis. These findings suggest new therapeutic targets for aldosterone receptor blockers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Zuzana Romanova, Natasa Hlavacova, Daniela Jezova
Summary: Chronic stress and adrenocortical hormone release have an impact on the development and treatment outcome of mental disorders. This review focuses on the modulation of cortisol and aldosterone secretion by antipsychotic drugs under stress and non-stress conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Andreas Walther, Clemens Kirschbaum, Susanne Wehrli, Nicole Rothe, Marlene Penz, Magdalena Wekenborg, Wei Gao
Summary: This study examines the role of the endocannabinoid system (ECS) in major depressive disorder (MDD) and its relationship with the glucocorticoid system. The findings suggest that higher depressive symptoms are associated with reduced levels of N-arachidonoylethanolamine (AEA) and cortisol. Longitudinal analyses reveal a negative association between AEA levels and depressive symptoms, while a positive association is found between 2-arachidonoyl-sn-glycerol/1-arachidonoyl-sn-glycerol (2-AG/1-AG) levels and depressive symptoms. These findings highlight AEA as a potential treatment target for MDD.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Gates B. Colbert, Mohamed E. Elrggal, Anna Gaddy, Hector M. Madariaga, Edgar V. Lerma
Summary: Hypertension is a key factor in the progression of cardiovascular disease in patients with chronic kidney disease, particularly diabetic kidney disease. Controlling hypertension can delay the progression of diabetic kidney disease. Several medications have been proven effective in real-world use, and new drugs are emerging.
JOURNAL OF CLINICAL MEDICINE
(2023)