Article
Psychology, Multidisciplinary
Julia Mehlhorn, Nelson Niski, Ke Liu, Svenja Caspers, Katrin Amunts, Christina Herold
Summary: This study provides a comprehensive and in-depth qualitative and quantitative analysis of different stages of adult neurogenesis in the brain of adult homing pigeons, revealing an uneven distribution of adult newborn neurons and glia, with the highest numbers found in the intercalated hyperpallium and the hippocampal formation.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Akshay Kumar, Syed Aasish Roshan, Muthuswamy Anusuyadevi, Mahesh Kandasamy
Summary: This study investigated the effect of aspirin on spatial memory in ageing experimental mice. Aspirin was found to enhance working memory, increase the number of new neurons in the hippocampus, reduce the number of microglial cells, and decrease the activity of AChE in the blood.
Article
Biochemistry & Molecular Biology
Ekaterina Kurilova, Maria Sidorova, Oksana Tuchina
Summary: We used a single prolonged stress protocol to study the susceptibility and neuroinflammatory response of C57BL/6 and wild-derived (house) mice to psychological trauma. The results showed that long-inbred C57BL/6 mice are more susceptible to prolonged stress and demonstrated elevated expression levels of proinflammatory cytokines in the hippocampus compared to house mice. The study also suggested that decreased microglia levels in the hippocampus of C57BL/6 mice might contribute to their sensitivity to prolonged stress.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Behavioral Sciences
Arthur Rocha-Gomes, Amanda Escobar Teixeira, Dalila Gomes de Oliveira, Camilla Mainy Oliveira Santiago, Alexandre Alves da Silva, Tania Regina Riul, Ana Cristina Rodrigues Lacerda, Vanessa Amaral Mendonca, Etel Rocha-Vieira, Hercules Ribeiro Leite
Summary: Maternal high-fat diets can induce inflammation in the offspring's amygdala leading to anxiety-like behaviors, but LPS tolerance can reduce this inflammation. Combining LPS tolerance with high-fat maternal diet can attenuate anxiety-like behavior through an anti-inflammatory compensatory response.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Esmaeil Amraie, Iran Pouraboli, Hossein Salehi, Ziba Rajaei
Summary: This study investigated the neuroprotective effects of treadmill running and Levisticum officinale extract on lipopolysaccharide-induced memory impairments and neuroinflammation in rats. The results showed that treadmill running and Levisticum officinale extract could attenuate spatial learning and memory deficits, reduce inflammation-related molecular expression and oxidative stress levels, and enhance neurogenesis.
METABOLIC BRAIN DISEASE
(2023)
Article
Pharmacology & Pharmacy
Wen-qiang Ren, Nuo Liu, Yan Shen, Xian-yan Wang, Qiong Zhou, Chen Rui, Xiao-han Yang, Sheng-long Cao, Ling-yu Li, Yan Wang, Qu-nan Wang
Summary: Subchronic exposure to DEHP may cause neurotoxicity by disrupting blood brain barrier function and inducing neuroinflammatory responses.
Article
Geriatrics & Gerontology
Nan Chen, Xin-Chen Wang, Ling-Ling Fan, Yu-Huang Zhu, Qi Wang, Yun-Bo Chen
Summary: The inflammatory response is a stress reaction to infection or injury, which can lead to cognitive impairment when the immune system is overactivated in the central nervous system. Berberine, an alkaloid extracted from Coptidis Rhizoma, has anti-inflammatory properties and has been shown to improve LPS-induced cognitive impairment through the SIRT1/NRF2/NF-kappa B signaling pathway.
REJUVENATION RESEARCH
(2022)
Article
Biology
P. Janssen, L. De Pauw, M. Mambretti, O. Lara, J. Walckiers, L. Mackens, I. Rooman, B. Guillaume, M. De Ridder, G. Ates, A. Massie
Summary: TBI followed by BMT had long-term impact on weight and locomotion but minimal effect on anxiety and depressive behavior. Impaired neurogenesis and cortical microglia activation were observed after TBI/BMT, and increased BBB permeability potentially contributed to the memory deficit.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Chemistry, Medicinal
Chao Zhang, Liang Chen, Xiaoling Wang, Pingkang Pan, Yong Tang, Pengli Hui
Summary: The study demonstrates that pumpkin has antioxidant and anti-inflammatory effects against LPS-induced neuroinflammation, restoring levels of enzymatic and non-enzymatic antioxidants, reducing oxidative stress markers, and decreasing the expression of proinflammatory cytokines.
PHARMACOGNOSY MAGAZINE
(2021)
Article
Neurosciences
Sachin P. Borikar, Shruti I. Dongare, Kishor R. Danao
Summary: The study aimed to investigate the therapeutic and preventive effects of agmatine on LPS-induced learning and memory impairment in mice. Results showed that agmatine treatment increased exploration to novel objects and reduced escape latency and time spent in the target quadrant in mice with LPS-induced memory deficits. Co-administration of agmatine with LPS also improved discrimination index in NOR test and decreased escape latency and time spent in the target quadrant in MWM test.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Wen Zeng, Kazumi Takashima, Qian Tang, Xinyu Zou, Ryota Ojiro, Shunsuke Ozawa, Meilan Jin, Yujiro Ando, Toshinori Yoshida, Makoto Shibutani
Summary: The study investigated the ameliorating effects of a natural antioxidant formula (NAF) on a lipopolysaccharide (LPS)-induced cognitive dysfunction model in rats. The results showed that NAF reduced brain inflammation and increased the number of M2-type cells. Additionally, NAF facilitated fear extinction learning and restored neural progenitor cell numbers and reelin+ hilar interneurons in the hippocampus.
JOURNAL OF CHEMICAL NEUROANATOMY
(2023)
Article
Cell Biology
Asmaa Jan Muhammad, Liangliang Hao, Lina Tariq Al Kury, Najeeb Ur Rehman, Arooj Mohsin Alvi, Haroon Badshah, Ikram Ullah, Fawad Ali Shah, Shupeng Li
Summary: This study found that carveol has a protective effect on LPS-induced depression, potentially through the activation of endogenous antioxidant Nrf2, which regulates antioxidant and anti-inflammatory pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Neurosciences
G. A. Grigoryan
Summary: This review examines the impact of ovariectomy on anxiety-depressive behavior in rodents and the mechanisms of estrogen replacement therapy. It considers factors such as age, timing of surgery, and testing in relation to behavior development. Additionally, it explores the various mechanisms of estrogen action in ovariectomized animals, including hormonal, biochemical, and intracellular signaling pathways.
NEUROCHEMICAL JOURNAL
(2022)
Article
Clinical Neurology
Gowri Natarajan, Jeffrey A. Leibowitz, Junli Zhou, Yang Zhao, Jessica A. McElroy, Michael A. King, Brandi K. Ormerod, Paul R. Carney
Article
Biochemistry & Molecular Biology
M. V. Lombardo, H. M. Moon, J. Su, T. D. Palmer, E. Courchesne, T. Pramparo
MOLECULAR PSYCHIATRY
(2018)
Article
Multidisciplinary Sciences
Hedwich F. Kuipers, Jane Yoon, Jack van Horssen, May H. Han, Paul L. Bollyky, Theo D. Palmer, Lawrence Steinman
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Cell Biology
Ninuo Xia, Fang Fang, Pengbo Zhang, Jun Cui, Chhavy Tep-Cullison, Tim Hamerley, Hyun Joo Lee, Theo Palmer, Brian Bothner, Jin Hyung Lee, Renee Reijo Pera
Article
Geriatrics & Gerontology
James A. McGuiness, Rachel B. Scheinert, Aditya Asokan, Vivien-Charlott Stadler, Christian S. Lee, Asha Rani, Ashok Kumar, Thomas C. Foster, Brandi K. Ormerod
FRONTIERS IN AGING NEUROSCIENCE
(2017)
Editorial Material
Immunology
Jeffrey A. Leibowitz, Brandi K. Ormerod
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Biochemistry & Molecular Biology
Zurine De Miguel, Ursula Haditsch, Theo D. Palmer, Arantza Azpiroz, Robert M. Sapolsky
MOLECULAR PSYCHIATRY
(2019)
Article
Biochemical Research Methods
Muthukumar Ramanathan, Karim Majzoub, Deepti S. Rao, Poornima H. Neela, Brian J. Zarnegar, Smarajit Mondal, Julien G. Roth, Hui Gai, Joanna R. Kovalski, Zurab Siprashvili, Theo D. Palmer, Jan E. Carette, Paul A. Khavari
Article
Geriatrics & Gerontology
Ashok Kumar, Asha Rani, Rachel B. Scheinert, Brandi K. Ormerod, Thomas C. Foster
NEUROBIOLOGY OF AGING
(2018)
Article
Clinical Neurology
Jeffrey A. Leibowitz, Gowri Natarajan, Junli Zhou, Paul R. Carney, Brandi K. Ormerod
Article
Neurosciences
Kwang-Min Kim, Alsu I. Zamaleeva, Youn Woo Lee, M. Rafiuddin Ahmed, Eunkyung Kim, Hye-Ryeon Lee, Venkata Raveendra Pothineni, Juan Tao, Siyeon Rhee, Mithya Jayakumar, Mohammed Inayathullah, Senthilkumar Sivanesan, Kristy Red-Horse, Theo D. Palmer, Jon Park, Daniel V. Madison, Ho-Young Lee, Jayakumar Rajadas
JOURNAL OF NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Anca M. Pasca, Jin-Young Park, Hyun-Woo Shin, Qihao Qi, Omer Revah, Rebecca Krasnoff, Ruth O'Hara, A. Jeremy Willsey, Theo D. Palmer, Sergiu P. Pascz
Article
Biology
Georgia Panagiotakos, Christos Haveles, Arpana Arjun, Ralitsa Petrova, Anshul Rana, Thomas Portmann, Sergiu P. Pasca, Theo D. Palmer, Ricardo E. Dolmetsch
Article
Multidisciplinary Sciences
Jessica L. Diaz, Verl B. Siththanandan, Victoria Lu, Nicole Gonzalez-Nava, Lincoln Pasquina, Jessica L. MacDonald, Mollie B. Woodworth, Abdulkadir Ozkan, Ramesh Nair, Zihuai He, Vibhu Sahni, Peter Sarnow, Theo D. Palmer, Jeffrey D. Macklis, Suzanne Tharin
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Neurosciences
Amy E. Braun, Pamela A. Carpentier, Brooke A. Babineau, Aditi R. Narayan, Michelle L. Kielhold, Hyang Mi Moon, Archana Shankar, Jennifer Su, Vidya Saravanapandian, Ursula Haditsch, Theo D. Palmer
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)