Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids

Proteome-Wide Reactivity Profiling Identifies Diverse Carbamate Chemotypes Tuned for Serine Hydrolase Inhibition

(2013) Jae Won Chang et al.   ACS Chemical Biology

Evaluation of NHS Carbamates as a Potent and Selective Class of Endocannabinoid Hydrolase Inhibitors

(2013) Micah J. Niphakis et al.   ACS Chemical Neuroscience

Monoacylglycerol Lipase Controls Endocannabinoid and Eicosanoid Signaling and Hepatic Injury in Mice

(2013) Zongxian Cao et al.   GASTROENTEROLOGY

Discovery and Optimization of Piperidyl-1,2,3-Triazole Ureas as Potent, Selective, and in Vivo-Active Inhibitors of α/β-Hydrolase Domain Containing 6 (ABHD6)

(2013) Ku-Lung Hsu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical approaches to study metabolic networks

(2013) Daniel Medina-Cleghorn et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice

(2013) Carolina Costola-de-Souza et al.   PLoS One

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

(2013) Jacqueline L. Blankman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome

(2013) Gwynneth Thomas et al.   Cell Reports

Highly Selective Inhibitors of Monoacylglycerol Lipase Bearing a Reactive Group that Is Bioisosteric with Endocannabinoid Substrates

(2012) Jae Won Chang et al.   CHEMISTRY & BIOLOGY

Therapeutic potential of monoacylglycerol lipase inhibitors

(2012) Melinda M. Mulvihill et al.   LIFE SCIENCES

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

(2012) Ku-Lung Hsu et al.   Nature Chemical Biology

The pharmacological landscape and therapeutic potential of serine hydrolases

(2012) Daniel A. Bachovchin et al.   NATURE REVIEWS DRUG DISCOVERY

A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer's Disease

(2012) Justin R. Piro et al.   Cell Reports

Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease

(2012) Rongqing Chen et al.   Cell Reports

Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats

(2011) Martin A Sticht et al.   BRITISH JOURNAL OF PHARMACOLOGY

Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer

(2011) Lin Ye et al.   CANCER LETTERS

Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer

(2011) Daniel K. Nomura et al.   CHEMISTRY & BIOLOGY

Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation

(2011) Mireille Alhouayek et al.   FASEB JOURNAL

Alterations of Endocannabinoid Signaling, Synaptic Plasticity, Learning, and Memory in Monoacylglycerol Lipase Knock-out Mice

(2011) B. Pan et al.   JOURNAL OF NEUROSCIENCE

Postsynaptic diacylglycerol lipase α mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex

(2011) Hiroki Yoshino et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reversible Gating of Endocannabinoid Plasticity in the Amygdala by Chronic Stress: A Potential Role for Monoacylglycerol Lipase Inhibition in the Prevention of Stress-Induced Behavioral Adaptation

(2011) Joshua J Sumislawski et al.   NEUROPSYCHOPHARMACOLOGY

Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain

(2011) Iryna A. Khasabova et al.   PHARMACOLOGICAL RESEARCH

Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats

(2011) Natale R. Sciolino et al.   PHARMACOLOGICAL RESEARCH

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Supply and demand for endocannabinoids

(2011) Bradley E. Alger et al.   TRENDS IN NEUROSCIENCES

Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain

(2010) Josée Guindon et al.   BRITISH JOURNAL OF PHARMACOLOGY

CB1 Cannabinoid Receptors and their Associated Proteins

(2010) Allyn Howlett et al.   CURRENT MEDICINAL CHEMISTRY

Activity-based Proteomics of Enzyme Superfamilies: Serine Hydrolases as a Case Study

(2010) Gabriel M. Simon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice

(2010) Y. Gao et al.   JOURNAL OF NEUROSCIENCE

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission

(2010) Asami Tanimura et al.   NEURON

DAG Lipase Involvement in Depolarization-Induced Suppression of Inhibition: Does Endocannabinoid Biosynthesis Always Meet the Demand?

(2010) Rogier Min et al.   NEUROSCIENTIST

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

(2010) Steven G. Kinsey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism

(2009) Jonathan Z. Long et al.   CHEMISTRY & BIOLOGY

Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2-Arachidonoylglycerol

(2009) Tiziana Bisogno et al.   ChemMedChem

Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain

(2009) S. G. Kinsey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Blockade of 2-Arachidonoylglycerol Hydrolysis by Selective Monoacylglycerol Lipase Inhibitor 4-Nitrophenyl 4-(Dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances Retrograde Endocannabinoid Signaling

(2009) B. Pan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

(2009) J. Z. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo

(2008) Tiziana Bisogno et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels

(2008) Daniel K. Nomura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System

(2008) Kay Ahn et al.   CHEMICAL REVIEWS

CB1 receptor antagonism: biological basis for metabolic effects

(2008) Vincenzo Di Marzo   DRUG DISCOVERY TODAY

N-Arachidonyl Maleimide Potentiates the Pharmacological and Biochemical Effects of the Endocannabinoid 2-Arachidonylglycerol through Inhibition of Monoacylglycerol Lipase

(2008) J. J. Burston et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Activation of the endocannabinoid system by organophosphorus nerve agents

(2008) Daniel K Nomura et al.   Nature Chemical Biology

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

CB2receptor-mediated migration of immune cells: it can go either way

(2007) A M Miller et al.   BRITISH JOURNAL OF PHARMACOLOGY