New insights into the impact of neuro-inflammation in rheumatoid arthritis

HLA and rheumatoid arthritis: How do they connect?

(2014) Jurgen van Heemst et al.   ANNALS OF MEDICINE

Safety of synthetic and biological DMARDs: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis

(2014) Sofia Ramiro et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial

(2014) Gerd-Rűdiger Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting TNF: a therapeutic strategy for Alzheimer's disease

(2014) Xin Cheng et al.   DRUG DISCOVERY TODAY

Loss of cerebral white matter in primary Sjögren's syndrome: a controlled volumetric magnetic resonance imaging study

(2014) M. B. Lauvsnes et al.   EUROPEAN JOURNAL OF NEUROLOGY

Peripheral inflammation is associated with remote global gene expression changes in the brain

(2014) Carolyn A Thomson et al.   Journal of Neuroinflammation

Infection risk in Rheumatoid Arthritis and Spondyloarthropathy patients under treatment with DMARDs, Corticosteroids and TNF-α antagonists

(2014) Valentina Germano et al.   Journal of Translational Medicine

Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice

(2014) E.R. Detrait et al.   NEUROCHEMISTRY INTERNATIONAL

Neurological adverse events in patients receiving anti-TNF therapy: a prospective imaging and electrophysiological study

(2014) Evripidis Kaltsonoudis et al.   ARTHRITIS RESEARCH & THERAPY

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

(2014) Victor Meseguer et al.   Nature Communications

Long-Term Safety of Subcutaneous Abatacept in Rheumatoid Arthritis: Integrated Analysis of Clinical Trial Data Representing More Than Four Years of Treatment

(2014) Rieke Alten et al.   Arthritis & Rheumatology

Periodontitis andPorphyromonas gingivalisin Patients With Rheumatoid Arthritis

(2014) Ted R. Mikuls et al.   Arthritis & Rheumatology

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update

(2013) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Trends in Serious Infections in Rheumatoid Arthritis

(2013) O. M. Ni Mhuircheartaigh et al.   JOURNAL OF RHEUMATOLOGY

Multimodal imaging in systemic lupus erythematosus patients with diffuse neuropsychiatric involvement

(2013) R Zivadinov et al.   LUPUS

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice

(2013) Donal T. Skelly et al.   PLoS One

Effect of Normal Aging Versus Hypertension, Abnormal Body Mass Index, and Diabetes Mellitus on White Matter Hyperintensity Volume

(2013) Kevin S. King et al.   STROKE

Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction

(2012) Jessica L. Teeling et al.   ACTA NEUROPATHOLOGICA

Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease

(2012) Gerd R Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Comparative effectiveness and safety of biological treatment options after tumour necrosis factor α inhibitor failure in rheumatoid arthritis: systematic review and indirect pairwise meta-analysis

(2012) Monika Schoels et al.   ANNALS OF THE RHEUMATIC DISEASES

Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis

(2012) Jose U. Scher et al.   ARTHRITIS AND RHEUMATISM

Association of brain functional magnetic resonance activity with response to tumor necrosis factor inhibition in rheumatoid arthritis

(2012) Juergen Rech et al.   ARTHRITIS AND RHEUMATISM

Noninvasive Molecular Imaging of Neuroinflammation

(2012) Andreas H Jacobs et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pharmacological modulation of brain activity in a preclinical model of osteoarthritis

(2012) Jaymin Upadhyay et al.   NEUROIMAGE

Interleukin-1 Inhibition and Fatigue in Primary Sjögren's Syndrome – A Double Blind, Randomised Clinical Trial

(2012) Katrine Brække Norheim et al.   PLoS One

Rheumatoid arthritis and the era of biologic therapy

(2012) Anshuman P. Malaviya et al.   INFLAMMOPHARMACOLOGY

Structural changes of the brain in rheumatoid arthritis

(2011) Karolina Wartolowska et al.   ARTHRITIS AND RHEUMATISM

Anti-TNF therapy: Safety aspects of taking the risk

(2011) Hemda Rosenblum et al.   AUTOIMMUNITY REVIEWS

Assessment of biocorrelates for brain involvement in female patients with rheumatoid arthritis

(2011) Sherifa A. Hamed et al.   CLINICAL RHEUMATOLOGY

Brain activity for chronic knee osteoarthritis: Dissociating evoked pain from spontaneous pain

(2011) Elle L. Parksl et al.   EUROPEAN JOURNAL OF PAIN

Potential role for S100A4 in the disruption of the blood–brain barrier in collagen-induced arthritic mice, an animal model of rheumatoid arthritis

(2011) T. Nishioku et al.   NEUROSCIENCE

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mapping the immunological homunculus

(2011) Betty Diamond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

White matter abnormalities in primary Sjogren syndrome

(2011) M. Akasbi et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

(2011) Yvonne C Lee et al.   ARTHRITIS RESEARCH & THERAPY

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

(2010) D. van der Woude et al.   ANNALS OF THE RHEUMATIC DISEASES

Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target

(2010) S. Capellino et al.   ANNALS OF THE RHEUMATIC DISEASES

Drug-specific risk of non-tuberculosis opportunistic infections in patients receiving anti-TNF therapy reported to the 3-year prospective French RATIO registry

(2010) D. Salmon-Ceron et al.   ANNALS OF THE RHEUMATIC DISEASES

Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: Implications for autoimmunity in rheumatoid arthritis

(2010) Natalia Wegner et al.   ARTHRITIS AND RHEUMATISM

How tumour necrosis factor blockers interfere with tuberculosis immunity

(2010) J. Harris et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immune Dysregulation by the Rheumatoid Arthritis Shared Epitope

(2010) D. E. De Almeida et al.   JOURNAL OF IMMUNOLOGY

Anti-TNF Therapy, from Rationale to Standard of Care: What Lessons Has It Taught Us?

(2010) M. Feldmann et al.   JOURNAL OF IMMUNOLOGY

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

White matter structural decline in normal ageing: A prospective longitudinal study using tract-based spatial statistics

(2010) Thomas R. Barrick et al.   NEUROIMAGE

Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate

(2010) Nicolas Fayed et al.   ARTHRITIS RESEARCH & THERAPY

Defining “Neuroinflammation”

(2009) James P. O'Callaghan et al.   Annals of the New York Academy of Sciences

Brain involvement in rheumatoid arthritis: A magnetic resonance spectroscopy study

(2009) Bart J. Emmer et al.   ARTHRITIS AND RHEUMATISM

Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective french research axed on tolerance of biotherapies registry

(2009) F. Tubach et al.   ARTHRITIS AND RHEUMATISM

How T-cell-dependent and -independent challenges access the brain: Vascular and neural responses to bacterial lipopolysaccharide and staphylococcal enterotoxin B

(2009) Jordi Serrats et al.   BRAIN BEHAVIOR AND IMMUNITY

The safety of anti-tumour necrosis factor therapy in rheumatoid arthritis

(2009) Johan Askling et al.   CURRENT OPINION IN RHEUMATOLOGY

Risk of Herpes Zoster in Patients With Rheumatoid Arthritis Treated With Anti–TNF-α Agents

(2009) Anja Strangfeld   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Specific interaction between genotype, smoking and autoimmunity to citrullinated α-enolase in the etiology of rheumatoid arthritis

(2009) Hiba Mahdi et al.   NATURE GENETICS

Time-resolved functional 1H MR spectroscopic detection of glutamate concentration changes in the brain during acute heat pain stimulation

(2009) Alexander Gussew et al.   NEUROIMAGE

Unusual central nervous system involvement of rheumatoid arthritis: successful treatment with steroid and azathioprine

(2009) Asuman Sengoz Inan et al.   RHEUMATOLOGY INTERNATIONAL

Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus

(2009) Yi Li et al.   ARTHRITIS RESEARCH & THERAPY

Risk of serious infections during rituximab, abatacept and anakinra treatments for rheumatoid arthritis: meta-analyses of randomised placebo-controlled trials

(2008) C Salliot et al.   ANNALS OF THE RHEUMATIC DISEASES

The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: meta and exposure-adjusted pooled analyses of serious adverse events

(2008) J P Leombruno et al.   ANNALS OF THE RHEUMATIC DISEASES

Immunity to Citrullinated Proteins in Rheumatoid Arthritis

(2008) Lars Klareskog et al.   Annual Review of Immunology

Investigation into the neural correlates of emotional augmentation of clinical pain

(2008) Petra Schweinhardt et al.   NEUROIMAGE

Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

(2007) Daniel Tracey et al.   PHARMACOLOGY & THERAPEUTICS