Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)

The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes

(2012) Srinivasan Rengachari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors

(2012) A Chicca et al.   BRITISH JOURNAL OF PHARMACOLOGY

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

2-Arachidonoylglycerol Signaling in Forebrain Regulates Systemic Energy Metabolism

(2012) Kwang-Mook Jung et al.   Cell Metabolism

Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradation

(2012) Niina Aaltonen et al.   BMC Pharmacology & Toxicology

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

(2011) J. R. Savinainen et al.   Acta Physiologica

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

Dual Inhibition of α/β-Hydrolase Domain 6 and Fatty Acid Amide Hydrolase Increases Endocannabinoid Levels in Neurons

(2011) William R. Marrs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

(2011) Ulrike Taschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Mutations in ABHD12 Cause the Neurodegenerative Disease PHARC: An Inborn Error of Endocannabinoid Metabolism

(2010) Torunn Fiskerstrand et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Activity-based Proteomics of Enzyme Superfamilies: Serine Hydrolases as a Case Study

(2010) Gabriel M. Simon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoacylglycerol Lipase Activity Is a Critical Modulator of the Tone and Integrity of the Endocannabinoid System

(2010) P. K. Chanda et al.   MOLECULAR PHARMACOLOGY

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

(2010) William R Marrs et al.   NATURE NEUROSCIENCE

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique

(2009) Juha R. Savinainen et al.   ANALYTICAL BIOCHEMISTRY

High expression of the evolutionarily conserved α/β hydrolase domain containing 6 (ABHD6) in Ewing tumors

(2009) Daniela Max et al.   CANCER SCIENCE

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors

(2009) Alvin R. King et al.   CHEMISTRY & BIOLOGY

Structural Basis for Human Monoglyceride Lipase Inhibition

(2009) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

(2008) Heather S. Hoover et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An unannotated α/β hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines

(2008) Fan Li et al.   MOLECULAR BIOLOGY REPORTS

Activation of the endocannabinoid system by organophosphorus nerve agents

(2008) Daniel K Nomura et al.   Nature Chemical Biology

CB2receptors in the brain: role in central immune function

(2007) G A Cabral et al.   BRITISH JOURNAL OF PHARMACOLOGY