Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology

The Impact of Dietary Interventions on the Symptoms of Inflammatory Bowel Disease: A Systematic Review

(2015) Ashley Charlebois et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Established and Potential Predictive Biomarkers in Gastrointestinal Cancer - c-Kit, Her2, Ras and Beyond

(2015) Christine Koch et al.   DIGESTION

Neutrophil Extracellular Traps in Ulcerative Colitis

(2015) Tue Bjerg Bennike et al.   INFLAMMATORY BOWEL DISEASES

Recognition of Bacterial Signal Peptides by Mammalian Formyl Peptide Receptors

(2015) Bernd Bufe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polymorphisms in NFKB1 and TLR4 and Interaction with Dietary and Life Style Factors in Relation to Colorectal Cancer in a Danish Prospective Case-Cohort Study

(2015) Tine Iskov Kopp et al.   PLoS One

Point-of-care testing in the diagnosis of gastrointestinal cancers: Current technology and future directions

(2015) Jeremy R Huddy   WORLD JOURNAL OF GASTROENTEROLOGY

Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses

(2015) Zhaohui Xie et al.   Drug Design Development and Therapy

High ABCC2 and Low ABCG2 Gene Expression Are Early Events in the Colorectal Adenoma-Carcinoma Sequence

(2015) Vibeke Andersen et al.   PLoS One

Association between high dietary intake of then−3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease

(2014) S. S. M. Chan et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The basic structure and dynamics of cell membranes: An update of the Singer–Nicolson model

(2014) Félix M. Goñi   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Environmental Risk Factors for Inflammatory Bowel Diseases: A Review

(2014) Ashwin N. Ananthakrishnan   DIGESTIVE DISEASES AND SCIENCES

A prospective, randomized, controlled, exploratory study of comprehensive dietary advice in ulcerative colitis

(2014) Moe H. Kyaw et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Prevalence of a Gluten-free Diet and Improvement of Clinical Symptoms in Patients with Inflammatory Bowel Diseases

(2014) Hans H. Herfarth et al.   INFLAMMATORY BOWEL DISEASES

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications

(2014) Jason R. Goldsmith et al.   JOURNAL OF GASTROENTEROLOGY

Cytokine crowdsourcing: multicellular production of TH 17-associated cytokines

(2014) Kathleen O. Busman-Sahay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-17+ Foxp3+ T cells: an intermediate differentiation stage between Th17 cells and regulatory T cells

(2014) Ruijuan Du et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Digesting the emerging role for the gut microbiome in central nervous system demyelination

(2014) Jennifer Joscelyn et al.   Multiple Sclerosis Journal

Predictive and prognostic biomarkers with therapeutic targets in advanced colorectal cancer

(2014) Hui-Yan Luo   WORLD JOURNAL OF GASTROENTEROLOGY

Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways

(2014) M E Delgado et al.   Cell Death & Disease

CD4CD8αα Lymphocytes, A Novel Human Regulatory T Cell Subset Induced by Colonic Bacteria and Deficient in Patients with Inflammatory Bowel Disease

(2014) Guillaume Sarrabayrouse et al.   PLOS BIOLOGY

Review article: evidence-based dietary advice for patients with inflammatory bowel disease

(2013) E. Richman et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Review article: the association of diet with onset and relapse in patients with inflammatory bowel disease

(2013) C. E. G. M. Spooren et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Cancer Risk in Inflammatory Bowel Disease According to Patient Phenotype and Treatment: A Danish Population-Based Cohort Study

(2013) Tine Jess et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function

(2013) Kazuhiro Katayama et al.   CANCER LETTERS

MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer

(2013) King Leung Fung et al.   CANCER RESEARCH

Diet and Inflammatory Bowel Disease: Review of Patient-Targeted Recommendations

(2013) Jason K. Hou et al.   Clinical Gastroenterology and Hepatology

Dietary arachidonic and oleic acid intake in ulcerative colitis etiology

(2013) Punyanganie S.A. de Silva et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies

(2013) David Ellinghaus et al.   GASTROENTEROLOGY

Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation

(2013) M Zaeem Cader et al.   GUT

TH17 Cell Induction and Effects of IL-17A and IL-17F Blockade in Experimental Colitis

(2013) Esben Gjerløff Wedebye Schmidt et al.   INFLAMMATORY BOWEL DISEASES

Increased Prevalence of Circulating Novel IL-17 Secreting Foxp3 Expressing CD4+ T Cells and Defective Suppressive Function of Circulating Foxp3+ Regulatory Cells Support Plasticity Between Th17 and Regulatory T Cells in Inflammatory Bowel Disease Patients

(2013) Aito Ueno et al.   INFLAMMATORY BOWEL DISEASES

High Residential Sun Exposure Is Associated With a Low Risk of Incident Crohnʼs Disease in the Prospective E3N Cohort

(2013) Prévost Jantchou et al.   INFLAMMATORY BOWEL DISEASES

Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update

(2013) M.J. Duffy et al.   INTERNATIONAL JOURNAL OF CANCER

P-glycoprotein ABCB1: a major player in drug handling by mammals

(2013) Piet Borst et al.   JOURNAL OF CLINICAL INVESTIGATION

High-Fat Diet-Induced Obesity Exacerbates Inflammatory Bowel Disease in Genetically Susceptible Mdr1a−/− Male Mice

(2013) Jisun Paik et al.   JOURNAL OF NUTRITION

The P-Glycoprotein Transport System and Cardiovascular Drugs

(2013) Jeffrey D. Wessler et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Low ABCB1 Gene Expression Is an Early Event in Colorectal Carcinogenesis

(2013) Vibeke Andersen et al.   PLoS One

Extracellular Vesicles Derived from Gut Microbiota, Especially Akkermansia muciniphila, Protect the Progression of Dextran Sulfate Sodium-Induced Colitis

(2013) Chil-sung Kang et al.   PLoS One

Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study

(2013) Vibeke Andersen et al.   PLoS One

Lactobacillus acidophilus Alleviates Platelet-Activating Factor-Induced Inflammatory Responses in Human Intestinal Epithelial Cells

(2013) Alip Borthakur et al.   PLoS One

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

(2013) J. G. M. Markle et al.   SCIENCE

Role of ABC transporters in lipid transport and human disease

(2013) Elizabeth J. Tarling et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics

(2013) Luca Pastorelli et al.   Frontiers in Immunology

Systematic review: diet-gene interactions and the risk of colorectal cancer

(2012) V. Andersen et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport

(2012) Jonathan A. Coleman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ABCB1/MDR1 gene polymorphism and colorectal cancer risk: a meta-analysis of case-control studies

(2012) T. He et al.   Colorectal Disease

The ABC of the Blood-Brain Barrier - Regulation of Drug Efflux Pumps

(2012) Anne Mahringer et al.   CURRENT PHARMACEUTICAL DESIGN

ABCG2 functions as a general phytoestrogen sulfate transporter in vivo

(2012) Koen van de Wetering et al.   FASEB JOURNAL

Enteral nutrition to suppress postoperative Crohn’s disease recurrence: a five-year prospective cohort study

(2012) Takayuki Yamamoto et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 1: Definitions and diagnosis

(2012) Axel Dignass et al.   Journal of Crohns & Colitis

Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure

(2012) Frantisek Staud et al.   JOURNAL OF DRUG TARGETING

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Altered generation of induced regulatory T cells in the FVB.mdr1a−/− mouse model of colitis

(2012) S M Tanner et al.   Mucosal Immunology

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Colorectal cancer—driven by inflammation and gut bacteria?

(2012) Katrina Ray   Nature Reviews Gastroenterology & Hepatology

The role of the gut microbiota in nutrition and health

(2012) Harry J. Flint et al.   Nature Reviews Gastroenterology & Hepatology

A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects

(2012) Harold Tjalsma et al.   NATURE REVIEWS MICROBIOLOGY

A Comprehensive Investigation on Common Polymorphisms in the MDR1/ABCB1 Transporter Gene and Susceptibility to Colorectal Cancer

(2012) Daniele Campa et al.   PLoS One

Murine P-glycoprotein Deficiency Alters Intestinal Injury Repair and Blunts Lipopolysaccharide-Induced Radioprotection

(2012) Elizabeth M. Staley et al.   RADIATION RESEARCH

ABCC2 transporter gene polymorphisms, diet and risk of colorectal cancer: a Danish prospective cohort study

(2012) Vibeke Andersen et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

Cellular and molecular mechanisms of intestinal fibrosis

(2012) Silvia Speca   WORLD JOURNAL OF GASTROENTEROLOGY

Review article: delivery and efficacy of topical 5-aminosalicylic acid (mesalazine) therapy in the treatment of ulcerative colitis

(2011) M. S. Harris et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding

(2011) J. Jasper Deuring et al.   BIOCHEMICAL JOURNAL

Impeded protein folding and function in active inflammatory bowel disease

(2011) J. Jasper Deuring et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Diet and risk of inflammatory bowel disease

(2011) Vibeke Andersen et al.   DIGESTIVE AND LIVER DISEASE

Lipid transport by mammalian ABC proteins

(2011) Faraz Quazi et al.   Essays in Biochemistry

Regulation of Homeostasis and Inflammation in the Intestine

(2011) Thomas T. MacDonald et al.   GASTROENTEROLOGY

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

(2011) Amanda M. Marchiando et al.   GASTROENTEROLOGY

Inflammasomes in Intestinal Inflammation and Cancer

(2011) Grace Y. Chen et al.   GASTROENTEROLOGY

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease

(2011) Clara Abraham et al.   GASTROENTEROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Protective Effect of Intestinal Trefoil Factor on Injury of Intestinal Epithelial Tight Junction Induced by Platelet Activating Factor

(2011) Ling-fen Xu et al.   INFLAMMATION

Is there evidence to claim or deny association between variants of the multidrug resistance gene (MDR1 or ABCB1) and inflammatory bowel disease?

(2011) Elias Zintzaras   INFLAMMATORY BOWEL DISEASES

Critical Role For P-Glycoprotein Expression in Hematopoietic Cells In The Fvb.Mdr1a−/− Model of Colitis

(2011) Elizabeth M Staley et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK)

(2011) L. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice

(2011) M. A. Kriegel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ABCB1 Protects Kidney Proximal Tubule Cells Against Cadmium-Induced Apoptosis: Roles of Cadmium and Ceramide Transport

(2011) Wing-Kee Lee et al.   TOXICOLOGICAL SCIENCES

Systematic review of genome-wide expression studies in multiple sclerosis

(2011) A. K. Kemppinen et al.   BMJ Open

Dysplasia and cancer in inflammatory bowel disease

(2011) Robert J Basseri et al.   Expert Review of Gastroenterology & Hepatology

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

(2010) Antonia H. Tolson et al.   ADVANCED DRUG DELIVERY REVIEWS

Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes

(2010) Vibeke Andersen et al.   BMC CANCER

Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study

(2010) Sneha John et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier

(2010) Xueqian Wang et al.   FASEB JOURNAL

Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field

(2010) S. Ogino et al.   GUT

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

(2010) Alan W Walker et al.   ISME Journal

Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells

(2010) Prabir K Chakraborty et al.   Molecular Cancer

Pim-1 Kinase Protects P-Glycoprotein from Degradation and Enables Its Glycosylation and Cell Surface Expression

(2010) Y. Xie et al.   MOLECULAR PHARMACOLOGY

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting IL-17 and Th17 Cells in Rheumatoid Arthritis

(2010) Sujata Sarkar et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Regulation of P-glycoprotein and other ABC drug transporters at the blood–brain barrier

(2010) David S. Miller   TRENDS IN PHARMACOLOGICAL SCIENCES

A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function

(2009) King Leung Fung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study

(2009) Vibeke Andersen et al.   BMC CANCER

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Transport of lipids by ABC proteins: Interactions and implications for cellular toxicity, viability and function

(2009) Irving L.M.H. Aye et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Lipid dependence of ABC transporter localization and function

(2009) Karin Klappe et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Recent insights into the pathogenesis of colorectal cancer

(2009) Ajay Goel et al.   CURRENT OPINION IN GASTROENTEROLOGY

Involvement of Vitamin D Receptor in the Intestinal Induction of Human ABCB1

(2009) S. Tachibana et al.   DRUG METABOLISM AND DISPOSITION

Differential regulation of interleukin 17 and interferon   production in inflammatory bowel disease

(2009) L. Rovedatti et al.   GUT

Multidrug resistance gene deficient (mdr1a-/-) mice have an altered caecal microbiota that precedes the onset of intestinal inflammation

(2009) K. Nones et al.   JOURNAL OF APPLIED MICROBIOLOGY

Synergy of IL-23 and Th17 Cytokines: New Light on Inflammatory Bowel Disease

(2009) Wei Shen et al.   NEUROCHEMICAL RESEARCH

Tissue Distribution, Gender-Divergent Expression, Ontogeny, and Chemical Induction of Multidrug Resistance Transporter Genes (Mdr1a, Mdr1b, Mdr2) in Mice

(2008) Y. J. Cui et al.   DRUG METABOLISM AND DISPOSITION

Nuclear Receptors and Inflammatory Diseases

(2008) Kun Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Autophagy and pattern recognition receptors in innate immunity

(2008) Monica Delgado et al.   IMMUNOLOGICAL REVIEWS

Early molecular and functional changes in colonic epithelium that precede increased gut permeability during colitis development in mdr1a(−/−) mice

(2008) Andrew Collett et al.   INFLAMMATORY BOWEL DISEASES

Differential susceptibility of P-glycoprotein deficient mice to colitis induction by environmental insults

(2008) Elizabeth M. Staley et al.   INFLAMMATORY BOWEL DISEASES

Activation of Pregnane X Receptor and Induction of MDR1 by Dietary Phytochemicals

(2008) Hideo Satsu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Reduction of dietary poorly absorbed short-chain carbohydrates (FODMAPs) improves abdominal symptoms in patients with inflammatory bowel disease—a pilot study

(2008) Richard B. Gearry et al.   Journal of Crohns & Colitis

A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer

(2008) Daniele Campa et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe

(2008) Bradley L. Urquhart et al.   Pharmacogenetics and Genomics

Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population

(2008) Mette Østergaard et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition

(2008) S.-F. Zhou   XENOBIOTICA