Article
Chemistry, Applied
Marielle Margier, Cedric Le May, Tiffany Antoine, Charlotte Halimi, Marion Nowicki, Anne Lespine, Emmanuelle Reboul
Summary: The study found that ABCB1 is involved in the efflux of vitamin K and regulates its absorption in mice models.
Article
Chemistry, Medicinal
Jiahao Zhu, Jieluan Lu, Yaodong He, Xianhuan Shen, Hanbing Xia, Wenzhou Li, Jianping Zhang, Xiaomei Fan
Summary: This study found that the polymorphisms of the ABCB1 gene are associated with the treatment outcomes of valproic acid in Chinese children with epilepsy. The TT genotype of rs1128503 is more likely to lead to persistent seizures after treatment, while the CC genotype of rs3789243 may be protective against gastrointestinal adverse drug reactions but increase the risk of cutaneous adverse drug reactions. However, the CT genotype of rs3789243 is associated with a lower risk of cutaneous adverse drug reactions. Additionally, carriers of the CC haplotype tend to respond better to valproic acid treatment.
Article
Computer Science, Information Systems
Yuan Zhang, Sai Zhang, Xizhi He, Jing Lu, Xieping Gao
Summary: A new deep neural network model, DeepRibSt, was proposed for predicting ribosome stalling sites. By processing ribosome footprinting data and extracting new features, a new network architecture was designed, showing superior performance over other methods in experimental validation.
MULTIMEDIA TOOLS AND APPLICATIONS
(2021)
Article
Ecology
Tess E. Brewer, Andreas Wagner
Summary: Fast-growing bacteria encode fewer di-prolyl motifs compared to slow-growing ones, especially in highly expressed proteins. Many di-prolyl motifs are found in thermophiles and bacteria with complex, multicellular lifecycles.
Article
Clinical Neurology
Duaa Eid Tamimi, Rami Abduljabbar, Al-Motassem Yousef, Ramzi Mukred Saeed, Mohammed Zawiah
Summary: This study identified a significant association between ABCB1 genetic polymorphisms and AED resistance in female epileptic patients, but not in males. Haplotype analysis revealed specific haplotypes that were significantly associated with AED resistance. Further research is needed to confirm these findings.
NEUROLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Leen Magarbeh, Claudia Hassel, Maximilian Choi, Farhana Islam, Victoria S. Marshe, Clement C. Zai, Rayyan Zuberi, Roseann S. Gammal, Xiaoyu Men, Maike Scherf-Clavel, Dietmar Enko, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar V. Parikh, Franca Placenza, Stephen C. Strother, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Stefan Kloiber, James L. Kennedy, Sidney H. Kennedy, Chad A. Bousman, Daniel J. Muller
Summary: In this study, the association between six ABCB1 single-nucleotide polymorphisms (SNPs) and antidepressant treatment outcomes was investigated through a systematic review and meta-analysis. No significant association was found between ABCB1 SNPs and antidepressant treatment outcomes in the CAN-BIND-1 sample. However, a significant association between rs1128503 and treatment response was observed in the meta-analysis. These findings provide limited evidence for the implementation of ABCB1 genotyping to inform antidepressant treatment.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Gabriel Stillemans, Happy Phanio Djokoto, Kevin-Alexandre Delongie, Halima El-Hamdaoui, Nadtha Panin, Vincent Haufroid, Laure Elens
Summary: Darunavir's intracellular penetration is limited by ABCB1 activity, which can vary due to genetic polymorphisms. The expression of ABCB1 affects the accumulation of darunavir, but there is no significant difference in efflux activity between cells expressing wild-type ABCB1 and variants.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Suman Rimal, Yu Li, Rasika Vartak, Ji Geng, Ishaq Tantray, Shuangxi Li, Sungun Huh, Hannes Vogel, Charles Glabe, Lea T. Grinberg, Salvatore Spina, William W. Seeley, Su Guo, Bingwei Lu
Summary: The metabolism of APP plays a central role in the pathogenesis of Alzheimer's disease, but the exact etiological driver is still unknown. Recent failures in clinical trials targeting Aβ peptides suggest that the key pathogenic species disrupting proteostasis have yet to be identified. The study indicates that ribosomes stall during the translation of APP.C99, leading to activation of RQC and ultimately causing proteostasis failure and cognitive deficits in AD models.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Oncology
Agnieszka Jelen, Marta Zebrowska-Nawrocka, Aleksandra Salagacka-Kubiak, Izabela Zawadzka, Mariusz Lochowski, Ewa Balcerczak
Summary: This study found that P-glycoprotein, a product of the ABCB1 gene, is important in the development of non-small cell lung cancer (NSCLC). The SNP C3435T was identified as a risk factor for NSCLC, and the T-T-T-T haplotype was found to be associated with NSCLC susceptibility.
JOURNAL OF ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kanyarat Boonprasert, Nanthawat Kosa, Poonuch Muhamad, Anurak Cheoymang, Kesara Na-Bangchang
Summary: The study found that ABCBl c.1236C>T polymorphisms could be useful genetic markers for predicting responses to the 3-day artesunate-mefloquine treatment. Patients carrying the TT genotype had a higher chance of successful treatment, while those with the CT genotype were more likely to experience treatment failure.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Biochemistry & Molecular Biology
Woo Sung Ahn, Hag Dong Kim, Tae Sung Kim, Myoung Jin Kwak, Yong Jun Park, Joon Kim
Summary: This study reveals that rpS3 interacts with Lyn and Lyn phosphorylates rpS3 to increase drug resistance in cells. Moreover, phosphorylation of rpS3 also upregulates the translation of P-glycoprotein.
Review
Biotechnology & Applied Microbiology
Md. Abdul Aziz, Mohammad Safiqul Islam
Summary: This study conducted a meta-analysis to validate the association between ABCB1 gene polymorphisms and steroid-resistant nephrotic syndrome (SRNS). The results showed that three common variants of ABCB1 gene were significantly associated with SRNS susceptibility in different populations.
JOURNAL OF GENE MEDICINE
(2022)
Article
Environmental Sciences
Jian Li, Lan Gao, Jing Chen, Wei-Wei Zhang, Xiao-Yi Zhang, Bo Wang, Cheng Zhang, Yan Wang, Yi-Chao Huang, Hua Wang, Wei Wei, De-Xiang Xu
Summary: In this research, it was discovered that acute exposure to 1-nitropyrene (1-NP) from polluted atmosphere resulted in a decline in testosterone (T) level in men. The study found that the reduction of T contents was caused by the downregulation of steroidogenic proteins in mouse testes and Leydig cells. The mechanism involved the activation of GCN2 and mitochondrial ROS-mediated ribosome stalling, leading to the inhibition of steroidogenic activity.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Huimin Wang, Guangzhi Yang, Dawei Sun, Boshen Wang, Hao Chen, Mengyao Chen, Baoli Zhu
Summary: The study found an association between genetic polymorphisms rs10499080 and rs6568819 within the HDAC2 gene and the risk of NIHL, indicating that workers exposed to noise with HDAC2 have a lower risk of NIHL.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Veterinary Sciences
Daniela Nuernberger, Simon F. Mueller, Melanie Hamann, Joachim Geyer
Summary: This report describes a Thuringian goat exhibiting neurological symptoms after treatment with a macrocyclic lactone compound, potentially linked to a Mdr1 gene defect. Sequencing revealed a single nucleotide polymorphism in the 3'-untranslated region of the suspected drug-sensitive goat's Mdr1 sequence. Further studies are needed to investigate the impact of this variant on Mdr1 mRNA expression and protein levels in brain tissue.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Trang Van Tran, Hoa Nguyen, Luyen Vu, ChangWoo Lee
Summary: Glutaredoxin 3 (Grx3) is a redox protein that maintains structural integrity and glutathione (GSH) binding capabilities across different temperatures. This study investigates the roles of specific bonds in Grx3's structure and function, and how psychrophilic Grx3 variants adapt to cold environments. The highly conserved Arg51-Asp69 salt bridge and Gln56-His63 hydrogen bond are crucial for stabilizing the structure and catalytic activity of Grx3. Psychrophilic variants of Grx3 have adapted to cold environments by reducing GSH binding and increasing structural flexibility.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2024)
Article
Biochemistry & Molecular Biology
Amanda Lais de Souza Coto, Arthur Alexandre Pereira, Sabrina Dorta Oliveira, Milene Nobrega de Oliveira Moritz, Arthur Moraes Franco da Rocha, Paulo Roberto Dores-Silva, Noeli Soares Melo da Silva, Ana Rita de Araujo Nogueira, Lisandra Marques Gava, Thiago Vagas Seraphim, Julio Cesar Borges
Summary: J-domain proteins form a large molecular chaperone family involved in proteostasis processes, with hDjC20 playing a vital role in mitochondria and being heavily influenced by the presence of Zn+2.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2024)
Article
Biochemistry & Molecular Biology
Meiling Zhang, Jiaxiang Zhang, Yan Liang, Shicheng Tian, Shuyang Xie, Tong Zhou, Qin Wang
Summary: This study determined the crystal structures of RGLG2 VWA domain in Arabidopsis thaliana, revealing that Ca2+ ions act as regulators and affect the conformational change of RGLG2-VWA domain.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2024)
Article
Biochemistry & Molecular Biology
Alexandra Bork, Sander H. J. Smits, Lutz Schmitt
Summary: This study reveals the structure and calcium ion binding properties of CBL1 protein, and proposes a binding model of CBL1 for Ca2+. Additionally, it provides preliminary insights into the formation of the dimer interface of CBL1.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2024)
Article
Biochemistry & Molecular Biology
Evgeniia V. Leisi, Andrey V. Moiseenko, Sofia S. Kudryavtseva, Denis V. Pozdyshev, Vladimir I. Muronetz, Lidia P. Kurochkina
Summary: The pathogenesis of prion diseases involves the transformation of prion protein into an insoluble form. This study found that two phage chaperonins can promote the fibrillation of prion protein in an ATP-dependent manner, resulting in the formation of less toxic large clusters. These fibrils differ in morphology and properties from those formed spontaneously in acidic pH with denaturants.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2024)
Article
Biochemistry & Molecular Biology
Gaurab Chowdhury, Saroj Biswas, Yuthika Dholey, Puja Panja, Sumit Das, Subrata Adak
Summary: Magnesium is an important divalent cation for regulating enzyme activity. The binding of Mg2+ through the PAS domain inhibits phosphoglycerate kinase (PGK) activity in LmPAS-PGK at neutral pH, but PGK activity is derepressed at acidic pH. Mutation studies revealed that the Asp-4 residue is crucial for Mg2+ binding at neutral pH.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2024)
Article
Biochemistry & Molecular Biology
Shima Ghaedizadeh, Majid Zeinali, Bahareh Dabirmanesh, Behnam Rasekh, Khosrow Khajeh, Ali Mohammad Banaei-Moghaddam
Summary: Implementing hyperthermostable carbonic anhydrases into CO2 capture and storage technologies can increase the rate of CO2 absorption from industrial flue gases. This study successfully improved the thermostability of a known hyperthermostable carbonic anhydrase through rational engineering of a single-point mutation.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2024)
Article
Biochemistry & Molecular Biology
Khaled A. Elnahriry, Dorothy C. C. Wai, Lauren M. Ashwood, Muhammad Umair Naseem, Tibor G. Szanto, Shaodong Guo, Gyorgy Panyi, Peter J. Prentis, Raymond S. Norton
Summary: Sea anemone venom contains a peptide called Tst2, which shows sequence similarity to peptides that interact with various ion channels. Recombinant Tst2 was successfully produced and its structure and function were studied. The results showed that Tst2 is an inhibitor of the TRPV1 channel.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2024)
