IL-17+ Foxp3+ T cells: an intermediate differentiation stage between Th17 cells and regulatory T cells

Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-  Are Resistant to Th17 Conversion by IL-6

(2014) S. G. Zheng et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

(2014) G. Lal et al.   JOURNAL OF IMMUNOLOGY

Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells

(2013) T. Guichelaar et al.   CLINICAL CANCER RESEARCH

In vitro generated Th17 cells support the expansion and phenotypic stability of CD4+Foxp3+ regulatory T cells in vivo

(2013) Qiong Zhou et al.   CYTOKINE

CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner

(2013) Behdad Afzali et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Co-activation through TLR4 and TLR9 but not TLR2 skews Treg-mediated modulation of Igs and induces IL-17 secretion in Treg:B cell co-cultures

(2013) Tomabu Adjobimey et al.   Innate Immunity

TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

(2013) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Reduced CD18 Levels Drive Regulatory T Cell Conversion into Th17 Cells in the CD18hypo PL/J Mouse Model of Psoriasis

(2013) K. Singh et al.   JOURNAL OF IMMUNOLOGY

Investigations on the clinical significance of FOXP3 protein expression in cervical oesophageal cancer and the number of FOXP3+ tumour-infiltrating lymphocytes

(2013) Ming Xia et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

Foxp3+Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production

(2012) Richard A. O'Connor et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibition of Interleukin-17 Promotes Differentiation of CD25– Cells Into Stable T Regulatory Cells in Patients With Autoimmune Hepatitis

(2012) Maria Serena Longhi et al.   GASTROENTEROLOGY

Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

(2012) Takahisa Miyao et al.   IMMUNITY

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

(2012) Naganari Ohkura et al.   IMMUNITY

Cancer-Related Inflammation

(2012) Juliana Candido et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The Presence of IL-17+/FOXP3+ Double-positive Cells in Periodontitis

(2012) T. Okui et al.   JOURNAL OF DENTAL RESEARCH

Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells

(2012) Jae-Hoon Chang et al.   NATURE IMMUNOLOGY

Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models

(2012) Li Shen et al.   PLoS One

Phenotypic and Functional Properties of Helios+ Regulatory T Cells

(2012) Daniel J. Zabransky et al.   PLoS One

Inflammation-Driven Reprogramming of CD4+Foxp3+ Regulatory T Cells into Pathogenic Th1/Th17 T Effectors Is Abrogated by mTOR Inhibition in vivo

(2012) Ekaterina Yurchenko et al.   PLoS One

A Protective Role by Interleukin-17F in Colon Tumorigenesis

(2012) Zan Tong et al.   PLoS One

Runx1 and Runx3 Are Involved in the Generation and Function of Highly Suppressive IL-17-Producing T Regulatory Cells

(2012) Lequn Li et al.   PLoS One

Expression of ROR t Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer

(2012) N. R. Blatner et al.   Science Translational Medicine

The targeted delivery of IL17 to the mouse tumor neo-vasculature enhances angiogenesis but does not reduce tumor growth rate

(2011) Nadine Pasche et al.   ANGIOGENESIS

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Human tumor-infiltrating Th17 cells have the capacity to differentiate into IFN-γ+ and FOXP3+ T cells with potent suppressive function

(2011) Jian Ye et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg

(2011) Christian Schmidl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Localization of IL-17+Foxp3+ T Cells in Esophageal Cancer

(2011) Chun Huang et al.   IMMUNOLOGICAL INVESTIGATIONS

IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo

(2011) Jonas Mudter et al.   INFLAMMATORY BOWEL DISEASES

SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production

(2011) Reiko Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ex Vivo IL-1 Receptor Type I Expression in Human CD4 + T Cells Identifies an Early Intermediate in the Differentiation of Th17 from FOXP3 + Naive Regulatory T Cells

(2011) Caroline Raffin et al.   JOURNAL OF IMMUNOLOGY

Functional Plasticity of Antigen-Specific Regulatory T Cells in Context of Tumor

(2011) C. Addey et al.   JOURNAL OF IMMUNOLOGY

IL-17 + Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer

(2011) Ilona Kryczek et al.   JOURNAL OF IMMUNOLOGY

TLR2 Stimulation Drives Human Naive and Effector Regulatory T Cells into a Th17-Like Phenotype with Reduced Suppressive Function

(2011) M. H. Nyirenda et al.   JOURNAL OF IMMUNOLOGY

The Plasticity of Regulatory T Cell Function

(2011) Meenu R. Pillai et al.   JOURNAL OF IMMUNOLOGY

Foxp3+ Regulatory T Cells of Psoriasis Patients Easily Differentiate into IL-17A-Producing Cells and Are Found in Lesional Skin

(2011) H. Jorn Bovenschen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Colorectal Cancer-Derived Foxp3+IL-17+ T Cells Suppress Tumour-Specific CD8+ T Cells

(2011) C. Ma et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Characterization of Interleukin-17–Producing Regulatory T Cells in Inflamed Intestinal Mucosa From Patients With Inflammatory Bowel Diseases

(2010) Zaruhi Hovhannisyan et al.   GASTROENTEROLOGY

Myelin-Reactive, TGF- -Induced Regulatory T Cells Can Be Programmed To Develop Th1-Like Effector Function but Remain Less Proinflammatory Than Myelin-Reactive Th1 Effectors and Can Suppress Pathogenic T Cell Clonal Expansion In Vivo

(2010) R. A. O'Connor et al.   JOURNAL OF IMMUNOLOGY

IL-1 -Mediated Signals Preferentially Drive Conversion of Regulatory T Cells but Not Conventional T Cells into IL-17-Producing Cells

(2010) L. Li et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Foxp3+ IL-17+ T cells promote development of cancer-initiating cells in colorectal cancer

(2010) Shaobo Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human ROR t+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors

(2010) D. Valmori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-17-producing human peripheral regulatory T cells retain suppressive function

(2009) G. Beriou et al.   BLOOD

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes

(2009) M. D. Sharma et al.   BLOOD

Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions

(2009) João H. Duarte et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

(2009) Ye Zheng et al.   NATURE

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor ROR t

(2009) M. Ayyoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity of natural Foxp3+T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

(2009) Noriko Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of IL-17-producing FOXP3+ regulatory T cells in humans

(2009) K. S. Voo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches

(2009) M. Tsuji et al.   SCIENCE

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

(2008) H. J. P. M. Koenen et al.   BLOOD

IL‐21 and IL‐21R are not required for development of Th17 cells and autoimmunityin vivo

(2008) Ivo Sonderegger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DC activated via dectin-1 convert Treg into IL-17 producers

(2008) Fabiola Osorio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

In vivo equilibrium of proinflammatory IL-17+and regulatory IL-10+Foxp3+RORγt+T cells

(2008) Matthias Lochner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Cytokine-based transformation of immune surveillance into tumor-promoting inflammation

(2008) J B Mumm et al.   ONCOGENE