Revisiting the evolutionary origins of obesity: lazy versus peppy-thrifty genotype hypothesis

Relation of Waist-Hip Ratio to Long-Term Cardiovascular Events in Patients With Coronary Artery Disease

(2018) Jose R. Medina-Inojosa et al.   AMERICAN JOURNAL OF CARDIOLOGY

Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model

(2018) Naomi R. Wray et al.   CELL

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

(2018) Masahiro Kanai et al.   NATURE GENETICS

Loss-of-function mutations in ADCY3 cause monogenic severe obesity

(2018) Sadia Saeed et al.   NATURE GENETICS

Time spent being sedentary and weight gain in healthy adults: reverse or bidirectional causality?

(2018) Ulf Ekelund et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults

(2017) Leandra Abarca-Gómez et al.   LANCET

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

(2017) Valérie Turcot et al.   NATURE GENETICS

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

(2017) Masato Akiyama et al.   NATURE GENETICS

A systematic review of genetic syndromes with obesity

(2017) Y. Kaur et al.   Obesity Reviews

On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations

(2017) A. Qasim et al.   Obesity Reviews

Ethnic and population differences in the genetic predisposition to human obesity

(2017) C. Stryjecki et al.   Obesity Reviews

Effectiveness of interventions to promote physical activity and/or decrease sedentary behaviour among rural adults: a systematic review and meta-analysis

(2017) V. Cleland et al.   Obesity Reviews

Circadian profiling in two mouse models of lysosomal storage disorders; Niemann Pick type-C and Sandhoff disease

(2016) Katie Richardson et al.   BEHAVIOURAL BRAIN RESEARCH

Analysis of Positive Selection at Single Nucleotide Polymorphisms Associated with Body Mass Index Does Not Support the “Thrifty Gene” Hypothesis

(2016) Guanlin Wang et al.   Cell Metabolism

The importance of gene-environment interactions in human obesity

(2016) H. Reddon et al.   CLINICAL SCIENCE

Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity

(2016) M. Pigeyre et al.   CLINICAL SCIENCE

Muscle dysfunction caused by loss ofMagel2in a mouse model of Prader-Willi and Schaaf-Yang syndromes

(2016) Ain A. Kamaludin et al.   HUMAN MOLECULAR GENETICS

A thrifty variant in CREBRF strongly influences body mass index in Samoans

(2016) Ryan L Minster et al.   NATURE GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Divergent effects of central melanocortin signalling on fat and sucrose preference in humans

(2016) Agatha A. van der Klaauw et al.   Nature Communications

Is Obesity Associated with Altered Energy Expenditure?

(2016) Isabella P Carneiro et al.   Advances in Nutrition

Analysis of energy metabolism in humans: A review of methodologies

(2016) Yan Y. Lam et al.   Molecular Metabolism

Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study

(2016) Hudson Reddon et al.   Scientific Reports

The Phenome-Wide Distribution of Genetic Variance

(2015) Mark W. Blows et al.   AMERICAN NATURALIST

A Genetic Basis for Motivated Exercise

(2015) Deborah J. Good et al.   EXERCISE AND SPORT SCIENCES REVIEWS

FTO association and interaction with time spent sitting

(2015) Y C Klimentidis et al.   INTERNATIONAL JOURNAL OF OBESITY

Leptin resistance in obesity: An epigenetic landscape

(2015) Ana B. Crujeiras et al.   LIFE SCIENCES

Deep phenotyping: The details of disease

(2015) Cathryn M. Delude   NATURE

Population genetic differentiation of height and body mass index across Europe

(2015) Matthew R Robinson et al.   NATURE GENETICS

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

(2015) Jian Yang et al.   NATURE GENETICS

Cognitive and autonomic determinants of energy homeostasis in obesity

(2015) Denis Richard   Nature Reviews Endocrinology

Are obesity risk genes associated with binge eating in adolescence?

(2015) Nadia Micali et al.   Obesity

Obesity, Abdominal Obesity, Physical Activity, and Caloric Intake in US Adults: 1988 to 2010

(2014) Uri Ladabaum et al.   AMERICAN JOURNAL OF MEDICINE

Methodological considerations for measuring spontaneous physical activity in rodents

(2014) Jennifer A. Teske et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

On the Evolutionary Origins of Obesity: A New Hypothesis

(2014) Dyan Sellayah et al.   ENDOCRINOLOGY

FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

(2014) Qibin Qi et al.   HUMAN MOLECULAR GENETICS

Validation of a method to measure total spontaneous physical activity of sedentary and voluntary running mice

(2014) M. Silvennoinen et al.   JOURNAL OF NEUROSCIENCE METHODS

Genetics of Regular Exercise and Sedentary Behaviors

(2014) Eco J.C. de Geus et al.   Twin Research and Human Genetics

Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies

(2014) Q. Qi et al.   BMJ-British Medical Journal

Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis

(2014) Rebecca C. Richmond et al.   PLOS MEDICINE

Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

(2013) Toshiko Tanaka et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Heritability of objectively assessed daily physical activity and sedentary behavior

(2013) Marcel den Hoed et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Circadian abnormalities in mouse models of smith-magenis syndrome: Evidence for involvement ofRAI1

(2013) Melanie Lacaria et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation

(2013) Laura R. Pearce et al.   CELL

Putting Pleiotropy and Selection Into Context Defines a New Paradigm for Interpreting Genetic Data

(2013) Irene M. Predazzi et al.   Circulation-Cardiovascular Genetics

Gene-Environment and Gene-Treatment Interactions in Type 2 Diabetes: Progress, pitfalls, and prospects

(2013) P. W. Franks et al.   DIABETES CARE

Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study

(2013) Gull Rukh et al.   Genes and Nutrition

A Novel Intronic Single Nucleotide Polymorphism in the Myosin heavy polypeptide 4 Gene Is Responsible for the Mini-Muscle Phenotype Characterized by Major Reduction in Hind-Limb Muscle Mass in Mice

(2013) S. A. Kelly et al.   GENETICS

Novel locus including FGF21 is associated with dietary macronutrient intake

(2013) Audrey Y. Chu et al.   HUMAN MOLECULAR GENETICS

Finding the missing heritability in pediatric obesity: the contribution of genome-wide complex trait analysis

(2013) C H Llewellyn et al.   INTERNATIONAL JOURNAL OF OBESITY

Rare variants in single-minded 1 (SIM1) are associated with severe obesity

(2013) Shwetha Ramachandrappa et al.   JOURNAL OF CLINICAL INVESTIGATION

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women

(2013) Marilyn C. Cornelis et al.   Obesity

Gene–environment contributions to energy and macronutrient intakes in 9-year-old children: Results from the Quebec Newborn Twin Study

(2013) Lise Dubois et al.   PHYSIOLOGY & BEHAVIOR

Sedentary behaviours and obesity in adults: the Cardiovascular Risk in Young Finns Study

(2013) I Heinonen et al.   BMJ Open

Validation of a buffet meal design in an experimental restaurant

(2012) Xavier Allirot et al.   APPETITE

Heritability of dietary food intake patterns

(2012) Linda van den Berg et al.   ACTA DIABETOLOGICA

Obesity susceptibility loci and dietary intake in the Look AHEAD Trial

(2012) Jeanne M McCaffery et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Letter to the Editor: Standardized use of the terms “sedentary” and “sedentary behaviours”

(2012) Sedentary Behaviour Research Networ   Applied Physiology Nutrition and Metabolism

Association of the fat mass and obesity-associated (FTO) gene variant (rs9939609) with dietary intake in the Finnish Diabetes Prevention Study

(2012) Tiina Lappalainen et al.   BRITISH JOURNAL OF NUTRITION

Television Watching, Leisure Time Physical Activity, and the Genetic Predisposition in Relation to Body Mass Index in Women and Men

(2012) Qibin Qi et al.   CIRCULATION

Molecular Basis of Obesity: Current Status and Future Prospects

(2012) Helene Choquet et al.   CURRENT GENOMICS

Alstrom Syndrome: Genetics and Clinical Overview

(2012) Jan D. Marshall et al.   CURRENT GENOMICS

Fat: an evolving issue

(2012) J. R. Speakman et al.   Disease Models & Mechanisms

A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis

(2012) J. R. Speakman et al.   Disease Models & Mechanisms

Bardet–Biedl syndrome

(2012) Elizabeth Forsythe et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The basis of antagonistic pleiotropy in hfq mutations that have opposite effects on fitness at slow and fast growth rates

(2012) R Maharjan et al.   HEREDITY

Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals

(2012) Yiran Guo et al.   HUMAN MOLECULAR GENETICS

Rate of weight gain predicts change in physical activity levels: a longitudinal analysis of the EPIC-Norfolk cohort

(2012) R Golubic et al.   INTERNATIONAL JOURNAL OF OBESITY

Challenges in reproducibility of genetic association studies: lessons learned from the obesity field

(2012) A Li et al.   INTERNATIONAL JOURNAL OF OBESITY

Human SH2B1 mutations are associated with maladaptive behaviors and obesity

(2012) Michael E. Doche et al.   JOURNAL OF CLINICAL INVESTIGATION

High Dietary Saturated Fat Intake Accentuates Obesity Risk Associated with the Fat Mass and Obesity–Associated Gene in Adults

(2012) Catherine M. Phillips et al.   JOURNAL OF NUTRITION

Sugar-Sweetened Beverages and Genetic Risk of Obesity

(2012) Qibin Qi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss-of-Function Mutations in MC4R Are Very Rare in the Greek Severely Obese Adult Population

(2012) Konstantinos Rouskas et al.   Obesity

A model of developmental evolution: selection, pleiotropy and compensation

(2012) Mihaela Pavlicev et al.   TRENDS IN ECOLOGY & EVOLUTION

The many faces of pleiotropy

(2012) Annalise B. Paaby et al.   TRENDS IN GENETICS

Influence of Physical Inactivity on Associations Between Single Nucleotide Polymorphisms and Genetic Predisposition to Childhood Obesity

(2011) B. Xi et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Abundant Pleiotropy in Human Complex Diseases and Traits

(2011) Shanya Sivakumaran et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Sedentary Behaviors and Subsequent Health Outcomes in Adults

(2011) Alicia A. Thorp et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Relationship of obesity to physical activity, domestic activities, and sedentary behaviours: cross-sectional findings from a national cohort of over 70,000 Thai adults

(2011) Emily Banks et al.   BMC PUBLIC HEALTH

Dietary fatty acid distribution modifies obesity risk linked to the rs9939609 polymorphism of the fat mass and obesity-associated gene in a Spanish case–control study of children

(2011) Adriana Moleres et al.   BRITISH JOURNAL OF NUTRITION

Lifestyle Interaction With Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women

(2011) T. Ahmad et al.   DIABETES CARE

Molecular Evolution, Mutation Size and Gene Pleiotropy: A Geometric Reexamination

(2011) P. Razeto-Barry et al.   GENETICS

A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI

(2011) Dolores Corella et al.   JOURNAL OF NUTRITION

The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms

(2011) Günter P. Wagner et al.   NATURE REVIEWS GENETICS

Dopamine D1 receptor modulation in nucleus accumbens lowers voluntary wheel running in rats bred to run high distances

(2011) Michael D. Roberts et al.   PHYSIOLOGY & BEHAVIOR

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

(2011) Tuomas O. Kilpeläinen et al.   PLOS MEDICINE

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Physiological and health implications of a sedentary lifestyle

(2010) Mark Stephen Tremblay et al.   Applied Physiology Nutrition and Metabolism

Too Much Sitting

(2010) Neville Owen et al.   EXERCISE AND SPORT SCIENCES REVIEWS

The Apolipoprotein E Gene and Taq1A Polymorphisms in Childhood Obesity

(2010) Mehmet Ali Ergun et al.   Genetic Testing and Molecular Biomarkers

One Hundred Years of Pleiotropy: A Retrospective

(2010) F. W. Stearns   GENETICS

Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions

(2010) Yann C. Klimentidis et al.   HUMAN GENETICS

Rai1 haploinsufficiency causes reduced Bdnf expression resulting in hyperphagia, obesity and altered fat distribution in mice and humans with no evidence of metabolic syndrome

(2010) Brooke Burns et al.   HUMAN MOLECULAR GENETICS

Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance

(2010) D. Jelinek et al.   HUMAN MOLECULAR GENETICS

Television viewing time independently predicts all-cause and cardiovascular mortality: the EPIC Norfolk Study

(2010) Katrien Wijndaele et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene–saturated fat interaction

(2010) D Corella et al.   INTERNATIONAL JOURNAL OF OBESITY

Association between fat intake, physical activity and mortality depending on genetic variation in FTO

(2010) E Sonestedt et al.   INTERNATIONAL JOURNAL OF OBESITY

Profound Obesity Secondary to Hyperphagia in Mice Lacking Kinase Suppressor of Ras 2

(2010) Jean-Pierre Revelli et al.   Obesity

Comparison of DEXA and QMR for assessing fat and lean body mass in adult rats

(2010) Colette N. Miller et al.   PHYSIOLOGY & BEHAVIOR

Genomic patterns of pleiotropy and the evolution of complexity

(2010) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection

(2010) S. R. Grossman et al.   SCIENCE

Physical Activity Attenuates the Genetic Predisposition to Obesity in 20,000 Men and Women from EPIC-Norfolk Prospective Population Study

(2010) Shengxu Li et al.   PLOS MEDICINE

APOA2, Dietary Fat, and Body Mass Index

(2009) Dolores Corella   ARCHIVES OF INTERNAL MEDICINE

Altered dopaminergic profiles: Implications for the regulation of voluntary physical activity

(2009) Amy M. Knab et al.   BEHAVIOURAL BRAIN RESEARCH

Shadows of complexity: what biological networks reveal about epistasis and pleiotropy

(2009) Anna L. Tyler et al.   BIOESSAYS

KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity

(2009) Diane L. Costanzo-Garvey et al.   Cell Metabolism

Ten Putative Contributors to the Obesity Epidemic

(2009) Emily J. McAllister et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

(2009) L. Southam et al.   DIABETOLOGIA

Common genetic variation near MC4R is associated with eating behaviour patterns in European populations

(2009) F Stutzmann et al.   INTERNATIONAL JOURNAL OF OBESITY

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

(2009) Prospective Studies Collaboration   LANCET

Metabolic syndrome: Aggression control mechanisms gone out of control

(2009) Prajakta V. Belsare et al.   MEDICAL HYPOTHESES

Television Time and Continuous Metabolic Risk in Physically Active Adults

(2009) GENEVIEVE N. HEALY et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Genome-Wide Association Study of Exercise Behavior in Dutch and American Adults

(2009) MARLEEN H.M. DE MOOR et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Sitting Time and Mortality from All Causes, Cardiovascular Disease, and Cancer

(2009) PETER T. KATZMARZYK et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Obesity,FTOGene Variant, and Energy Intake in Children

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Decreased Npc1 Gene Dosage in Mice Is Associated With Weight Gain

(2009) David Jelinek et al.   Obesity

Stress-induced obesity and the emotional nervous system

(2009) Mary F. Dallman   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Eating rate is a heritable phenotype related to weight in children

(2008) Clare H Llewellyn et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes?

(2008) Reinhard Stöger   BIOESSAYS

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

Smith–Magenis syndrome

(2008) Sarah H Elsea et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Prader–Willi syndrome

(2008) Suzanne B Cassidy et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Nhlh2

(2008) Deborah J. Good et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Modularity in the genetic disease-phenotype network

(2008) Xingpeng Jiang et al.   FEBS LETTERS

Increased constraints on MC4R during primate and human evolution

(2008) David A. Hughes et al.   HUMAN GENETICS

Thrifty genes for obesity, an attractive but flawed idea and an alternative perspective: the ‘drifty gene’ hypothesis

(2008) J R Speakman   INTERNATIONAL JOURNAL OF OBESITY

Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins

(2008) L Mustelin et al.   INTERNATIONAL JOURNAL OF OBESITY

Genetic influence on appetite in children

(2008) S Carnell et al.   INTERNATIONAL JOURNAL OF OBESITY

Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome

(2008) Kamal Rahmouni et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenotypic Effects of the "Mini-Muscle" Allele in a Large HR x C57BL/6J Mouse Backcross

(2008) R. M. Hannon et al.   JOURNAL OF HEREDITY

Pleiotropic scaling of gene effects and the ‘cost of complexity’

(2008) Günter P. Wagner et al.   NATURE

Genetic and environmental contributions to food use patterns of young adult twins

(2007) Kaisu Keskitalo et al.   PHYSIOLOGY & BEHAVIOR