The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms

The origins and evolution of genetic disease risk in modern humans

(2010) Bernard J. Crespi   Annals of the New York Academy of Sciences

FISHER'S MODEL AND THE GENOMICS OF ADAPTATION: RESTRICTED PLEIOTROPY, HETEROGENOUS MUTATION, AND PARALLEL EVOLUTION

(2010) Luis-Miguel Chevin et al.   EVOLUTION

One Hundred Years of Pleiotropy: A Retrospective

(2010) F. W. Stearns   GENETICS

The energetics of genome complexity

(2010) Nick Lane et al.   NATURE

Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks

(2010) Xionglei He et al.   NATURE GENETICS

Genomic patterns of pleiotropy and the evolution of complexity

(2010) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shadows of complexity: what biological networks reveal about epistasis and pleiotropy

(2009) Anna L. Tyler et al.   BIOESSAYS

The Developmental Basis of Variational Modularity: Insights from Quantitative Genetics, Morphometrics, and Developmental Biology

(2009) Philipp Mitteroecker   Evolutionary Biology

Measuring Morphological Integration Using Eigenvalue Variance

(2009) Mihaela Pavlicev et al.   Evolutionary Biology

Genetic architecture of quantitative traits in mice, flies, and humans

(2009) J. Flint et al.   GENOME RESEARCH

A preliminary analysis of gene pleiotropy estimated from protein sequences

(2009) Zhixi Su et al.   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Common disorders are quantitative traits

(2009) Robert Plomin et al.   NATURE REVIEWS GENETICS

Detecting gene–gene interactions that underlie human diseases

(2009) Heather J Cordell   NATURE REVIEWS GENETICS

The genetics of quantitative traits: challenges and prospects

(2009) Trudy F. C. Mackay et al.   NATURE REVIEWS GENETICS

Measuring and comparing evolvability and constraint in multivariate characters

(2008) T. F. HANSEN et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Pleiotropic scaling and QTL data

(2008) Joachim Hermisson et al.   NATURE

Pleiotropic scaling of gene effects and the ‘cost of complexity’

(2008) Günter P. Wagner et al.   NATURE

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS