Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity

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Selective PDE inhibitors as novel treatments for respiratory diseases

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Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB

(2012) Fera Y. Goh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

DNA damage as a molecular link in the pathogenesis of COPD in smokers

(2012) Kazutetsu Aoshiba et al.   EUROPEAN RESPIRATORY JOURNAL

Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease

(2011) Klaus F. Rabe   BRITISH JOURNAL OF PHARMACOLOGY

Development of Neh2-Luciferase Reporter and Its Application for High Throughput Screening and Real-Time Monitoring of Nrf2 Activators

(2011) Natalya A. Smirnova et al.   CHEMISTRY & BIOLOGY

Oxidative DNA Damage and Somatic Mutations

(2011) Eleni G. Tzortzaki et al.   CHEST

Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer

(2011) Jonathan Chee Woei Lim et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease

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Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Sulforaphane Induces Antioxidative and Antiproliferative Responses by Generating Reactive Oxygen Species in Human Bronchial Epithelial BEAS-2B Cells

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Novel Chalcone Derivatives as Potent Nrf2 Activators in Mice and Human Lung Epithelial Cells

(2011) Vineet Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

Nitrative stress in inflammatory lung diseases

(2011) Hisatoshi Sugiura et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

(2011) Hongwei Yao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease

(2011) A. Boutten et al.   TRENDS IN MOLECULAR MEDICINE

Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown

(2010) Saskia Braber et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Neutralizing Granulocyte/Macrophage Colony–Stimulating Factor Inhibits Cigarette Smoke–induced Lung Inflammation

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Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

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Glutathione cycle in stable chronic obstructive pulmonary disease

(2010) Vanja Radišić Biljak et al.   CELL BIOCHEMISTRY AND FUNCTION

Biologic and pharmacologic therapies in clinical development for the inflammatory response in COPD

(2010) Jaymin B. Morjaria et al.   DRUG DISCOVERY TODAY

Induction of Heme Oxygenase 1 and Inhibition of Tumor Necrosis Factor α-Induced Intercellular Adhesion Molecule Expression by Andrographolide in EA.hy926 Cells

(2010) Ai-Lin Yu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

New Therapies for Chronic Obstructive Pulmonary Disease

(2010) Peter J. Barnes   MEDICAL PRINCIPLES AND PRACTICE

A Novel Antiinflammatory Role for Andrographolide in Asthma via Inhibition of the Nuclear Factor-κB Pathway

(2009) Zhang Bao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

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(2009) Ralf-Harto Hubner et al.   MOLECULAR MEDICINE

Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and  -radiation-induced cell death

(2009) M. M. Cortes-Wanstreet et al.   MUTAGENESIS

MMP12,Lung Function, and COPD in High-Risk Populations

(2009) Gary M. Hunninghake et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunologic Aspects of Chronic Obstructive Pulmonary Disease

(2009) Manuel G. Cosio et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats

(2009) Ka H. Chan et al.   RESPIRATORY MEDICINE

Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione

(2008) Carolyn J. Baglole et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function

(2008) Thomas H. Thatcher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

(2008) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Distal Airways in Mice Exposed to Cigarette Smoke

(2008) Tracy L. Adair-Kirk et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

(2008) Neal L. Benowitz   Annual Review of Pharmacology and Toxicology

Inhibition of the Epstein–Barr Virus Lytic Cycle by Andrographolide

(2008) Tsuey-Pin Lin et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Molecular Mechanisms of Corticosteroid Resistance

(2008) Ian M. Adcock et al.   CHEST

In vitro and in vivo anti-inflammatory effects of andrographolide

(2008) Ala'a A. Abu-Ghefreh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Comparison of Cigarette Smoke-Induced Acute Inflammation in Multiple Strains of Mice and the Effect of a Matrix Metalloproteinase Inhibitor on These Responses

(2008) A. Morris et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro nicotine induced superoxide mediated DNA fragmentation in lymphocytes: Protective role of Andrographis paniculata Nees

(2008) Subhasis Das et al.   TOXICOLOGY IN VITRO

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

(2007) Aruna Kode et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Recent advances in plant hepatoprotectives: A chemical and biological profile of some important leads

(2007) Arvind S. Negi et al.   MEDICINAL RESEARCH REVIEWS