Article
Immunology
Deqing Yang, Dan Xu, Tao Wang, Zhicheng Yuan, Lian Liu, Yongchun Shen, Fuqiang Wen
Summary: Pre-treatment with MitoQ significantly attenuated cigarette smoke-induced airway inflammation and mucus hypersecretion in mice, potentially by modulating mitochondrial function and the NF-kappa B signal pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Toxicology
Saurabh Kumar, Shama Parveen, Suchit Swaroop, Monisha Banerjee
Summary: Cigarette smoke exposure leads to oxidative stress and degradation of alveolar cell walls, causing emphysema. The present study found that cigarette smoke extract (CSE) affects mucus hypersecretion in A549 cells through TNF-a and MMPs mediated pathways. CSE reduces cell viability, induces apoptosis, reduces mitochondrial membrane potential, and increases intracellular ROS production. CSE also increases the expression of TNF-a, MMP-7, MMP-12, MUC5AC, and MUC5B. Overall, CSE induces mucus production in the lungs through TNF-a and MMPs mediated pathways.
TOXICOLOGY IN VITRO
(2023)
Article
Food Science & Technology
Yao Lu, Yutao Zhou, Yingying Lin, Wusun Li, Shousheng Tian, Xianghui Hao, Huiyuan Guo
Summary: The study found that oral administration of donkey milk powder can improve asthma symptoms, alleviate airway injury and fibrosis, reduce mucin accumulation, goblet cell hyperplasia, and airway inflammation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Wei Li, Lu Xue, Changsi Peng, Ping Zhao, Yongbo Peng, Weiwei Chen, Wenyi Wang, Jinhua Shen
Summary: PP121 exerts dual anti-contractile and anti-inflammatory effects in asthma treatment by blocking specific ion channels and downregulating inflammatory factors, mucins, and the MAPK/Akt signaling pathway in asthmatic mice, suggesting it as a promising therapeutic compound for asthma therapy.
MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Zhenwei Xia, Wenwei Zhong
Summary: HO-1 plays a crucial immunoregulatory role in asthmatic airway inflammation by regulating various immune cells and exerting anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Dong-Uk Shin, Ji-Eun Eom, Hyeon-Ji Song, Sun Young Jung, Thi Van Nguyen, Kyung Min Lim, Ok Hee Chai, Hyun-Jin Kim, Gun-Dong Kim, Hee Soon Shin, So-Young Lee
Summary: Cigarette smoke is a major factor in the development of chronic obstructive pulmonary disease (COPD). This study investigated the protective effects of Camellia sinensis extract against pulmonary inflammation in a COPD mouse model. The extract suppressed immune cell infiltration, cytokine secretion, mucus hypersecretion, and lung parenchyma injuries. In vitro experiments revealed its inhibitory effect on inflammation-related molecules in various cell types. The results suggest that Camellia sinensis extract could be an effective approach for treating or preventing chronic pulmonary diseases.
Article
Pharmacology & Pharmacy
Sohi Kang, Hyun-Yong Kim, A. Yeong Lee, Hyo Seon Kim, Jun Hong Park, Byeong Cheol Moon, Hyeon Hwa Nam, Sung-Wook Chae, Bokyung Jung, Changjong Moon, In Sik Shin, Joong Sun Kim, Yun-Soo Seo
Summary: In this study, the effects of Camellia sinensis extract on ovalbumin-induced allergic asthma were evaluated. The results showed that the extract had anti-inflammatory and antioxidant activities, and could suppress the progression of asthma.
Article
Pharmacology & Pharmacy
Michael D. Kim, Samuel Chung, John S. Dennis, Makoto Yoshida, Carolina Aguiar, Sheyla P. Aller, Eliana S. Mendes, Andreas Schmid, Juan Sabater, Nathalie Baumlin, Matthias Salathe
Summary: This study found that VG-containing e-cigarette aerosols can reduce mucociliary function and induce inflammation in the airway. Similar results were observed in both animal models and cell cultures. Therefore, VG e-cigarette aerosols may potentially cause harm to the respiratory system.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Mirrin J. Dorresteijn, Douwe Dekker, Jelle Zwaag, Suzanne Heemskerk, Hennie M. J. Roelofs, Paul Smits, Johannes G. van der Hoeven, Frank A. D. T. G. Wagener, Peter Pickkers
Summary: Inflammation-induced free radical release is important in the pathogenesis of several diseases. This study investigated the impact of atazanavir-induced hyperbilirubinemia on antioxidant capacity, inflammation, and vascular dysfunction in human experimental endotoxemia. The results showed that hyperbilirubinemia increased antioxidant capacity, attenuated interleukin-10 release, and prevented vascular hyporesponsiveness during systemic inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Sarath S. Kumar, Aiswarya Binu, Aswathy R. Devan, Lekshmi R. Nath
Summary: COVID-19 is a highly contagious disease that can lead to pneumonia and organ infections, posing a major burden on global healthcare systems. Research shows typical mucus hypersecretion and mucus plugging in COVID-19 patients, emphasizing the need for further study on the exact role of mucus in exacerbating COVID-19 symptoms.
MEDICAL HYPOTHESES
(2021)
Article
Medicine, Research & Experimental
Haoshen Feng, Rui Zheng
Summary: Chronic obstructive pulmonary disease (COPD) is an inflammatory disease caused by smoking. The study found that M1 polarization levels were decreased in smokers and COPD patients, while M2 polarization was unchanged. Further experiments showed that smoking may suppress M1 polarization of AMs by inhibiting NLRP3.
Article
Plant Sciences
Hyeon Hwa Nam, Ji Hye Lee, Seung Mok Ryu, Sueun Lee, Sungyu Yang, Pureum Noh, Byung Cheol Moon, Joong Sun Kim, Yun-Soo Seo
Summary: The study demonstrates that Gekko gecko extract (GGE) can alleviate asthma-induced inflammation by regulating the activation and differentiation of Th2 cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Marko Manevski, Dinesh Devadoss, Christopher Long, Shashi P. Singh, Mohd Wasim Nasser, Glen M. Borchert, Madhavan N. Nair, Irfan Rahman, Mohan Sopori, Hitendra S. Chand
Summary: Research has found that long noncoding RNA (lncRNA) plays an important role in cigarette smoke exposure and chronic obstructive pulmonary disease. Blocking the expression of lncRNA can alleviate inflammation and excessive mucus production caused by cigarette smoke.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Dereje Tassew, Susan Fort, Yohannes Mebratu, Jacob McDonald, Hong Wei Chu, Hans Petersen, Yohannes Tesfaigzi
Summary: Exposure to wood smoke (WS) increases mucin expression more efficiently than exposure to cigarette smoke (CS), especially in a p53 pathway-dependent manner. The WS constituent oxalate can enhance mucin expression, particularly in individuals with a p53 arginine genotype, revealing potential mechanisms for increased risk of chronic bronchitis. Identifying responsible compounds and genetic variations could help estimate pollutant-related risks and improve lung disease management strategies.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Immunology
Simone N. De Luca, Kurt Brassington, Stanley M. H. Chan, Aleksandar Dobric, Kevin Mou, Huei Jiunn Seow, Ross Vlahos
Summary: The study revealed that smoking can impair pulmonary and neurocognitive functions, leading to memory deficits and microglial activation. While smoking cessation can reduce lung inflammation, its effectiveness in improving memory deficits and microglial activation remains uncertain. Antioxidant therapy may help prevent smoking-induced memory impairment.
JOURNAL OF NEUROINFLAMMATION
(2022)
Letter
Allergy
Laurent Orsi, Marine Savoure, Jean Bousquet, Benedicte Jacquemin, Valerie Siroux, Maritta S. Jaakkola, Jouni J. K. Jaakkola, Benedicte Leynaert, Rachel Nadif
Article
Respiratory System
Marine Savoure, Jean Bousquet, Benedicte Leynaert, Adeline Renuy, Valerie Siroux, Marcel Goldberg, Marie Zins, Benedicte Jacquemin, Rachel Nadif
Summary: A population-based cohort study in France found that the prevalence of allergic rhinitis (AR) and non-allergic rhinitis (NAR) in adults was 28.0% and 10.9%, respectively. AR patients were more likely to have persistent and moderate-to-severe rhinitis, and those with a history of asthma and conjunctivitis had earlier onset and more severe symptoms. These findings provide new insights for the management of rhinitis and its comorbidities.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Kevin W. Southern, Carlo Castellani, Elise Lammertyn, Alan Smyth, Donald VanDevanter, Silke van Koningsbruggen-Rietschel, Juerg Barben, Amanda Bevan, Edwin Brokaar, Sarah Collins, Gary J. Connett, Thomas W. V. Daniels, Jane Davies, Dimitri Declercq, Silvia Gartner, Andrea Gramegna, Naomi Hamilton, Jenny Hauser, Nataliya Kashirskaya, Laurence Kessler, Jacqueline Lowdon, Halyna Makukh, Clemence Martin, Lisa Morrison, Dilip Nazareth, Jacquelien Noordhoek, Ciaran O'Neill, Elizabeth Owen, Helen Oxley, Karen S. Raraigh, Caroline Raynal, Karen Robinson, Jobst Roehmel, Carsten Schwarz, Isabelle Sermet, Michal Shteinberg, Ian Sinha, Constance Takawira, Peter van Mourik, Marieke Verkleij, Michael D. Waller, Alistair Duff
Summary: Cystic fibrosis (CF) has entered the era of variant-specific therapy, tailored to the genetic variants in the CFTR gene, and CFTR modulators, the first available therapy, have transformed CF management. Interim standards have been produced to guide healthcare professionals in providing variant-specific therapy for CF patients using evidence-based guidance and stakeholder consultation.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Pharmacology & Pharmacy
Rodrigo de Oliveira Formiga, Flavia C. Amaral, Camila F. Souza, Daniel A. G. B. Mendes, Carlos W. S. Wanderley, Cristina B. Lorenzini, Adara A. Santos, Juliana Antonia, Lucas F. Faria, Caio C. Natale, Nicholas M. Paula, Priscila C. S. Silva, Fernanda R. Fonseca, Luan Aires, Nicoli Heck, Marick R. Starick, Celso M. Queiroz-Junior, Felipe R. S. Santos, Filipe R. O. de Souza, Vivian V. Costa, Shana P. C. Barroso, Alexandre Morrot, Johan Van Weyenbergh, Regina Sordi, Frederico Alisson-Silva, Fernando Q. Cunha, Edroaldo L. Rocha, Sylvie Chollet-Martin, Maria Margarita Hurtado-Nedelec, Clemence Martin, Pierre-Regis Burgel, Daniel S. Mansur, Rosemeri Maurici, Matthew S. Macauley, Andre Bafica, Veronique Witko-Sarsat, Fernando Spiller
Summary: This study investigated the role of host neuraminidase (NEU) in neutrophil dysregulation during severe infections. The researchers found that oseltamivir and zanamivir can inhibit NEU activity and reduce neutrophil overactivation, suggesting NEU as a potential host-directed target to regulate neutrophil dysfunction.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jean-Francois Llitjos, Cedric Auffray, Edwige Peju, Zakaria Ait Hamou, Christophe Rousseau, Aurelie Durand, Clemence Martin, Jean-Paul Mira, Pierre-Regis Burgel, Jean-Daniel Chiche, Maha Zohra Ladjemi, Bruno Lucas, Frederic Pene
Summary: Clinical observations suggest that the source of primary infection is a major determinant of further nosocomial pneumonia in critically ill patients with sepsis. This study used relevant double-hit animal models to investigate the impact of primary nonpulmonary or pulmonary sepsis on lung immunity. The results indicate that polymicrobial peritonitis and bacterial pneumonia confer susceptibility or resistance to secondary gram-negative pulmonary infection, respectively, through immune modulation and cross-talk between regulatory T cells and alveolar macrophages.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Respiratory System
Pierre-Regis Burgel, Isabelle Sermet-Gaudelus, Isabelle Durieu, Reem Kanaan, Julie Macey, Dominique Grenet, Michele Porzio, Nathalie Coolen-Allou, Raphael Chiron, Christophe Marguet, Benoit Douvry, Nadine Dufeu, Isabelle Danner-Boucher, Pierre Foucaud, Lydie Lemonnier, Emmanuelle Girodon, Jennifer Da Silva, Clemence Martin, French CF Reference Network Study Grp
Summary: The European Medicines Agency has approved the CFTR modulator combination elexacaftor/tezacaftor/ivacaftor for CF patients carrying certain variants. An observational study evaluated the effectiveness of this treatment in CF patients with advanced lung disease who did not meet the eligibility criteria in Europe. The results showed significant clinical benefits in a subset of patients.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Respiratory System
Lucile Regard, Pierre-Regis Burgel, Nicolas Roche
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Physiology
Randa Belgacemi, Bruno Ribeiro Baptista, Gregoire Justeau, Marylene Toigo, Andrew Frauenpreis, Rojda Yilmaz, Audrey Der Vartanian, Mathieu Cazaunau, Edouard Pangui, Antonin Berge, Aline Gratien, Juan Camilo Macias Rodriguez, Saverio Bellusci, Genevieve Derumeaux, Jorge Boczkowski, Denise Al Alam, Patrice Coll, Sophie Lanone, Laurent Boyer
Summary: This study investigates how urban pollution affects alveolar stem cell niches in mice. The research finds that exposure to representative urban atmospheres leads to a shift from lipofibroblasts to myofibroblasts in the alveolar mesenchymal stem cell niche, as well as dysfunction in alveolar epithelial cells and a fibrotic-like phenotype.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Editorial Material
Critical Care Medicine
Lucile Regard, Nicolas Roche, Pierre-R Egis Burgel
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Elise Dreano, Pierre Regis Burgel, Aurelie Hatton, Naim Bouazza, Benoit Chevalier, Julie Macey, Sylvie Leroy, Isabelle Durieu, Laurence Weiss, Dominique Grenet, Nathalie Stremler, Camille Ohlmann, Philippe Reix, Michele Porzio, Pauline Roux Claude, Natacha Remus, Benoit Douvry, Sylvie Montcouquiol, Laure Cosson, Julie Mankikian, Jeanne Languepin, Veronique Houdouin, Laurence Le Clainche, Anne Guillaumot, Delphine Pouradier, Adrien Tissot, Pascaline Priou, Laurent Mely, Frederique Chedevergne, Muriel Lebourgeois, Jean Lebihan, Clemence Martin, Flora Zavala, Jennifer Da Silva, Lydie Lemonnier, Mairead Kelly-Aubert, Anita Golec, Pierre Foucaud, Christophe Marguet, Aleksander Edelman, Alexandre Hinzpeter, Paola de Carli, Emmanuelle Girodon, Isabelle Sermet-Gaudelus, Iwona Pranke
Summary: This study explored the feasibility of using ETI for the treatment of cystic fibrosis patients without the F508del mutation. The results showed that ETI significantly increased the activity of CFTR variants that met FDA criteria and also had an effective effect on variants that did not meet FDA criteria. The correlation between Delta I-ETI/DMSO%WT and changes in ppFEV(1) and sweat chloride concentration can predict the efficacy of ETI. In addition, the study found that some CFTR modulators had better effects on certain variants compared to ETI.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Marcin Piechota, Dzesika Hoinkis, Michal Korostynski, Slawomir Golda, Joanna Pera, Tomasz Dziedzic
Summary: Gene expression profiling in blood cells stimulated with lipopolysaccharide may be useful for predicting post-stroke depressive symptoms in patients without a history of depression. A model containing 6 genes (PKM, PRRC2C, NUP188, CHMP3, H2AC8, NOP10) showed good discriminatory properties for identifying post-stroke depressive symptoms.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Oncology
Miguel Cosenza-Contreras, Agnes Schafer, Justin Sing, Lena Cook, Maren N. Stillger, Chia-Yi Chen, Jose Villacorta Hidalgo, Niko Pinter, Larissa Meyer, Tilman Werner, Darleen Bug, Zeno Haberl, Oliver Kuebeck, Kai Zhao, Susanne Stei, Anca Violeta Gafencu, Radu Ionita, Felix M. Brehar, Jaime Ferrer-Lozano, Gloria Ribas, Leo Cerda-Alberich, Luis Marti-Bonmati, Christopher Nimsky, Alexis Van Straaten, Martin L. Biniossek, Melanie Foll, Nina Cabezas-Wallscheid, Jorg Buscher, Hannes Rost, Armelle Arnoux, Jorg W. Bartsch, Oliver Schilling
Summary: This study utilized proteomics and lipidomics to analyze patient-matched initial and recurrent glioblastoma specimens, revealing increased immune cell infiltration and extracellular matrix reorganization in recurrent glioblastoma. ASAH1 and SYNM were identified as potential plasma markers for the progression of recurrent glioblastoma.
Article
Respiratory System
Anne-Elie Carsin, Judith Garcia-Aymerich, Simone Accordini, Shyamali Dharmage, Benedicte Leynaert, Marti de las Heras, Lidia Casas, Seraina Caviezel, Pascal Demoly, Bertil Forsberg, Thorarinn Gislason, Angelo Guido Corsico, Christer Janson, Rain Jogi, Jesus Martinez-Moratalla, Dennis Nowak, Leopoldo Palacios Gomez, Isabelle Pin, Nicole Probst-Hensch, Chantal Raherison-Semjen, Giulia Squillacioti, Cecilie Svanes, Kjell Toren, Isabel Urrutia, Ismael Huerta, Josep Maria Anto, Debbie Jarvis, Stefano Guerra
Summary: This study aimed to describe the characteristics and risk factors of restrictive and obstructive spirometric patterns occurring before 40 years (young onset) and between 40 and 61 years (mid-adult onset). Data from the European Community Respiratory Health Survey (ECRHS) were used, and longitudinal assessments of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were conducted.
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul Habert, Antoine Decoux, Lilia Chermati, Laure Gibault, Pascal Thomas, Arthur Varoquaux, Francoise Le Pimpec-Barthes, Armelle Arnoux, Loic Juquel, Kathia Chaumoitre, Stephane Garcia, Jean-Yves Gaubert, Loic Duron, Laure Fournier
Summary: The study aimed to differentiate lung carcinoids and atypical hamartomas using contrast-enhanced CT semantic and radiomics criteria. The results showed that radiomics features could accurately distinguish these tumors, with 3D segmentations demonstrating better reproducibility.
INSIGHTS INTO IMAGING
(2023)