Article
Cell & Tissue Engineering
Zhengjun Peng, Lu Liu, Wenyu Zhang, Xi Wei
Summary: Communication between dental-derived cells in coculture environments can enhance the pluripotency of cells. Cell proliferation and apoptosis are inhibited, and the cell cycle is arrested at the G0/G1 phase in coculture. STAT3 plays a crucial role in regulating the pluripotency of DPCs and PDLCs by directly binding to Oct-4 and Sox2 gene promoter regions.
STEM CELLS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Kelly J. Peyton, Ghazaleh Behnammanesh, Giovanna L. Durante, William Durante
Summary: Research shows that canagliflozin can act as a novel inducer of HO-1 in human ECs. While HO-1 contributes to the anti-inflammatory action, it does not affect the anti-proliferative and antimigratory effects of the drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Soo-Jin Son, SeokJin Jang, HyungChul Rah, SeokHwa Choi
Summary: Miniature pig DPSCs and PDLSCs exhibit higher proliferation rates compared to domestic farm pig breeds, but show lower osteogenic abilities.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Zhenwei Xia, Wenwei Zhong
Summary: HO-1 plays a crucial immunoregulatory role in asthmatic airway inflammation by regulating various immune cells and exerting anti-inflammatory effects.
Article
Neurosciences
Flavia Bittencourt Brasil, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Evandro Luiz Dall'Oglio, Marcos Roberto de Oliveira
Summary: The C-glucosyl flavone isoorientin (ISO) has cytoprotective effects on mitochondria by activating the Nrf2/HO-1 pathway, preventing oxidative damage and inflammation caused by chemical stressors.
NEUROTOXICITY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Edina Pandur, Kitti Tamasi, Ramona Pap, Gergely Janosa, Katalin Sipos
Summary: Macrophages are essential immune cells that play a fundamental role in fighting bacterial infections through phagocytosis and cytokine secretion. Different bacterial cell wall components have varying effects on cytokine production and iron metabolism in macrophages, ultimately influencing the outcome of bacterial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Joseana de Oliveira, Marina B. Denadai, Diego L. Costa
Summary: Heme oxygenase-1 (HO-1) plays a crucial role in iron metabolism and has the potential to modulate immunity and inflammation through regulating cellular oxidation reactions and the expression of inflammation-related proteins.
Review
Biochemistry & Molecular Biology
Akihiro Yachie
Summary: HO-1 is crucial in protecting tissues and organs from oxidative stress and excessive inflammatory reactions. Deficiency in HO-1 leads to dysfunction in monocytes, macrophages, and endothelial cells, resulting in systemic inflammatory response syndrome. Therapeutic induction of HO-1 production through pharmacological intervention shows promise in controlling inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Kim Ngan Luu Hoang, Joanne E. Anstee, James N. Arnold
Summary: HO-1 is an inducible intracellular enzyme expressed in various cancers to promote tumor progression through intracellular and extracellular mechanisms. Its catabolites provide antioxidant, anti-apoptotic, and cytoprotective effects within cells, while also influencing the wider tumor microenvironment to promote processes like angiogenesis, metastasis, anti-inflammation, and immune suppression. Pharmacological inhibition of HO-1 shows promise in inhibiting metastasis and promoting anti-tumor immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eman Y. Gohar, Rawan N. Almutlaq, Chunlan Fan, Rohan S. Balkawade, Maryam K. Butt, Lisa M. Curtis
Summary: This study suggests that G protein-coupled estrogen receptor 1 (GPER1) does not play a significant role in cisplatin-induced acute kidney injury (AKI), but its deletion exacerbates renal apoptosis and diminishes heme oxygenase-1 (HO-1) induction, indicating potentially important cytoprotective and anti-apoptotic actions of GPER1 in AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Adaylu A. Argaez-Sosa, Beatriz A. Rodas-Junco, Leydi M. Carrillo-Cocom, Rafael A. Rojas-Herrera, Abel Coral-Sosa, Fernando J. Aguilar-Ayala, David Aguilar-Perez, Geovanny I. Nic-Can
Summary: Obesity is a major global health issue that is reaching concerning levels. Excessive consumption of high-energy foods can lead to metabolic dysfunction and the development of obesity-related diseases. Recent research has revealed the role of tight epigenetic reprogramming in the development of adipocytes, and it is of interest to explore whether the epigenetic mechanisms vary in different tissues. This study investigates the contribution of DNA methylation to the adipogenic potential of dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PLSCs) during adipogenic differentiation in vitro, providing insights into the factors influencing cell differentiation and potential strategies for regulating adipocyte expansion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Vidhya M. Ravi, Nicolas Neidert, Paulina Will, Kevin Joseph, Julian P. Maier, Jan Kueckelhaus, Lea Vollmer, Jonathan M. Goeldner, Simon P. Behringer, Florian Scherer, Melanie Boerries, Marie Follo, Tobias Weiss, Daniel Delev, Julius Kernbach, Pamela Franco, Nils Schallner, Christine Dierks, Maria Stella Carro, Ulrich G. Hofmann, Christian Fung, Roman Sankowski, Marco Prinz, Juergen Beck, Henrike Salie, Bertram Bengsch, Oliver Schnell, Dieter Henrik Heiland
Summary: The study demonstrates that a subset of myeloid cells in Glioblastomas induce dysfunctional T cells through Interleukin-10 signaling, and inhibiting downstream JAK/STAT pathway could restore the responsiveness of immune therapy. The findings are validated using in vitro and in vivo models, providing further evidence of Interleukin-10 release being a driving force of tumor immune escape. Integrative modeling of single cell and spatial transcriptomics data proves to be a valuable tool for studying the tumor immune microenvironment and may contribute to the development of successful immunotherapies.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Natasha M. Nesbitt, Lisa E. Malone, Zhaoyan Liu, Alexander Jares, Dmitri V. Gnatenko, Yupo Ma, Wei Zhu, Wadie F. Bahou
Summary: The cytoprotective functions of heme oxygenases involve the generation of carbon monoxide, ferrous iron, and bilirubin, with downstream biliverdin reductases playing a key role in cellular protection, especially in stress hematopoiesis. Blvrb is identified as a crucial driver in stress cytoprotection and redox-regulated lineage partitioning in erythroid/megakaryocyte lineage speciation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sukjoon Lee, Dongzi Chen, Munsu Park, Sunil Kim, Yoon Jeong Choi, Seok Jun Moon, Dong Min Shin, Ji Hyun Lee, Euiseong Kim
Summary: Single-cell RNA sequencing revealed distinct gene expression patterns in specific clusters of human dental pulp stem cells (hDPSCs) and human periodontal ligament stem cells (hPDLSCs). hDPSCs exhibited osteogenic and neurogenic cell populations, while hPDLSCs mainly comprised osteogenic and myofibroblastic populations. The results can serve as valuable resources for further research in dental therapeutics.
JOURNAL OF ENDODONTICS
(2022)
Article
Immunology
Renata Sesti-Costa, Marina Dorigatti Borges, Carolina Lanaro, Dulcineia Martins de Albuquerque, Sara Terezinha Olalla Saad, Fernando Ferreira Costa
Summary: This study identified the circulating DC subpopulations in patients with SCD and found higher numbers and percentages of DCs in the patients compared to healthy individuals. Inflammatory DCs and activated mo-DCs played a critical role in cytokine production and skewing of T lymphocyte response in patients with SCD.
FRONTIERS IN IMMUNOLOGY
(2021)