Article
Multidisciplinary Sciences
Laura Janko, Emese Toth, Miklos Laczik, Boglarka Rauch, Eszter Janka, Balint L. Balint, Peter Bai
Summary: PARP2 plays a role in DNA repair and has regulatory functions in mitochondrial and lipid metabolism. It is also involved in the adverse effects of pharmacological PARP inhibitors. Silencing of PARP2 affects the subcellular localization of NRF2, a regulator of cellular antioxidant defense, and leads to changes in the expression of genes encoding proteins with antioxidant function.
SCIENTIFIC REPORTS
(2023)
Article
Fisheries
Yun Wang, Yafei Duan, Jianhua Huang, Jun Wang, Chuanpeng Zhou, Shigui Jiang, Heizhao Lin, Zhe Zhang
Summary: PmNrf2, a member of CNC-bZIP transcription factor family, is constitutively expressed in various tissues of shrimp and responds to bacterial challenge. Knockdown of PmNrf2 results in decreased expression of PmGPx gene, indicating its role in regulating the transcription of antioxidant enzyme genes in shrimp.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Daniela Maria Tanase, Alina Georgiana Apostol, Claudia Florida Costea, Claudia Cristina Tarniceriu, Ionut Tudorancea, Minela Aida Maranduca, Mariana Floria, Ionela Lacramioara Serban
Summary: Arterial hypertension is a prevalent disease characterized by increased incidence and heterogeneous pathophysiology. Oxidative stress plays an important role in its development, with excessive levels causing vascular cell damage and promoting hypertension. Transcription factors such as Nrf2 mediate antioxidant response pathways and provide protection.
Article
Biochemistry & Molecular Biology
Mariko Shiraiwa, Tomoya Kitakaze, Yoko Yamashita, Yuichi Ukawa, Katsuyuki Mukai, Hitoshi Ashida
Summary: Pectolinarigenin (PG) and its glycoside pectolinarin (PN) have various health benefits and direct antioxidant activity. This study found that PG can indirectly induce the expression of antioxidant enzymes through the Nrf2/ARE pathway, thus protecting the liver from oxidative stress.
Article
Agriculture, Multidisciplinary
Song Liu, Huan-Huan Qin, Xin-Ran Ji, Jian-Wen Gan, Meng-Jia Sun, Jin Tao, Zhuo-Qi Tao, Guang-Nian Zhao, Bing-Xin Ma
Summary: New Nrf2 agonists were identified through deep-learning screening, which increased Nrf2 activity in damaged cells and were confirmed to be safe.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Shunxi Zhang, Jiahe Zhao, Zhihuai Bai, Lina Luo, Fan Wu, Baolong Li, Yujuan Shan
Summary: The study suggests that sulforaphane (SFN) may have potential therapeutic effects on Alzheimer's disease by improving AD symptoms through Nrf2 activation. SFN reduced escape latency and increased target-zone frequency in rats, improved pathological morphology and neuron numbers in the hippocampus, and modulated antioxidant reactions by upregulating thioredoxin and glutathione content, along with Nrf2 protein expression, while reducing A beta content and ROS levels. Additionally, SFN's inhibitory effects on ROS and A beta production were partially weakened after silencing Nrf2 with SiRNA.
Article
Microbiology
Yue Qu, Aline Haas de Mello, Dorothea R. Morris, Yava L. Jones-Hall, Teodora Ivanciuc, Rachel A. Sattler, Slobodan Paessler, Vineet D. Menachery, Roberto P. Garofalo, Antonella Casola
Summary: SARS-CoV-2 infection disrupts the redox balance by downregulating NRF2 and its dependent genes, exacerbating lung inflammation and disease. Activation of NRF2 could be explored as a therapeutic approach during SARS-CoV-2 infection.
MICROBIOLOGY SPECTRUM
(2023)
Review
Biochemistry & Molecular Biology
Muchtaridi Muchtaridi, Siti Rafa Amirah, Jacko Abiwaqash Harmonis, Emmy Hainida Khairul Ikram
Summary: Long COVID-19 syndrome is a different condition compared to typical recovery, and natural antioxidant compounds that modulate the Nrf2 signaling pathway can help reduce and treat this syndrome.
Article
Biochemistry & Molecular Biology
Lee E. Neilson, Joseph F. Quinn, Nora E. Gray
Summary: NRF2, a transcription factor critical in maintaining cellular redox balance, has been identified as a therapeutic target in various human diseases. PBMCs can serve as a convenient source of biomarkers to monitor NRF2 activation and disease progression in clinical trials, indicating their potential as exploratory markers for targeting NRF2 activation.
Article
Biochemistry & Molecular Biology
Jaeeun Lee, Joo Weon Lim, Hyeyoung Kim
Summary: Alcohol increases gut permeability, leading to pancreatic damage. Ethanol or LPS treatment increases ROS production. Lycopene inhibits IL-6 expression and reduces ROS levels through the Nrf2 pathway.
Article
Biochemistry & Molecular Biology
Maria Grazia Rossino, Rosario Amato, Marialaura Amadio, Michela Rosini, Filippo Basagni, Maurizio Cammalleri, Massimo Dal Monte, Giovanni Casini
Summary: The study found that NIH1 can enhance nuclear translocation of Nrf2, inhibit retinal damage caused by oxidative stress, and prevent apoptotic cell death and gliotic reactivity induced by oxidative stress.
Review
Medicine, Research & Experimental
Kasra Shirvanian, Reyhaneh Vali, Tahereh Farkhondeh, Amir Abderam, Michael Aschner, Saeed Samarghandian
Summary: Genistein, a flavonoid mainly found in soybean, exhibits antioxidant and anti-inflammatory properties. It interacts with estrogen receptors and inhibits protein tyrosine kinases. Genistein attenuates oxidative stress through various cellular mechanisms.
CURRENT MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Changhai Tian, Lie Gao, Irving H. Zucker
Summary: The balance between pro- and antioxidant molecules is crucial in the pathogenesis of cardiovascular disease, particularly in chronic heart failure where oxidative stress is a significant factor. Nrf2 and antioxidant enzyme signaling pathways play a key role in regulating redox balance in heart and brain in heart failure.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Shengqiang Li, Zhen Lei, Meng Zhao, Yonghao Hou, Di Wang, Xingli Xu, Xiaowen Lin, Jingxin Li, Shuhai Tang, Jingui Yu, Tao Meng
Summary: Propofol can reduce myocardial I/R injury by activating PKC/NRF2 pathway, leading to increased antioxidant enzyme expression and decreased levels of lactate dehydrogenase and creatine kinase-MB.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Zhijiang Chen, Huili Wang, Bin Hu, Xinxin Chen, Meiyu Zheng, Lili Liang, Juanjuan Lyu, Qiyi Zeng
Summary: Mitochondrial dysfunction plays a role in the development of S-AKI, and NRF2 activation can help restore mitochondrial homeostasis and function.
EUROPEAN JOURNAL OF HISTOCHEMISTRY
(2022)