Flat and microstructured polymeric membranes in organs-on-chips

Microimpedance tomography system to monitor cell activity and membrane movements in a breathing lung-on-chip

(2018) Y. Mermoud et al.   SENSORS AND ACTUATORS B-CHEMICAL

A microfluidic circulatory system integrated with capillary-assisted pressure sensors

(2017) Yangfan Chen et al.   LAB ON A CHIP

Rapid large area fabrication of multiscale through-hole membranes

(2017) Dongha Tahk et al.   LAB ON A CHIP

Simultaneous electrical recording of cardiac electrophysiology and contraction on chip

(2017) Fang Qian et al.   LAB ON A CHIP

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

(2017) Duc T. T. Phan et al.   LAB ON A CHIP

WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue

(2017) Peter Loskill et al.   LAB ON A CHIP

3D-templated, fully automated microfluidic input/output multiplexer for endocrine tissue culture and secretion sampling

(2017) Xiangpeng Li et al.   LAB ON A CHIP

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities

(2017) Ben M. Maoz et al.   LAB ON A CHIP

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Pore Spacing Can Modulate Endothelial Cell–Substrate and Cell–Cell Interactions

(2017) Stephanie M. Casillo et al.   ACS Biomaterials-Science & Engineering

Membrane Pore Spacing Can Modulate Endothelial Cell–Substrate and Cell–Cell Interactions

(2017) Stephanie M. Casillo et al.   ACS Biomaterials Science & Engineering

Engineering Solutions for Representative Models of the Gastrointestinal Human-Microbe Interface

(2017) Marc Mac Giolla Eain et al.   Engineering

A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing

(2017) Fang Yu et al.   Scientific Reports

Ultrathin Polymer Membranes with Patterned, Micrometric Pores for Organs-on-Chips

(2016) Virginia Pensabene et al.   ACS Applied Materials & Interfaces

Cell sheet mechanics: How geometrical constraints induce the detachment of cell sheets from concave surfaces

(2016) Tadahiro Yamashita et al.   Acta Biomaterialia

Use of electrospinning and dynamic air focusing to create three-dimensional cell culture scaffolds in microfluidic devices

(2016) Chengpeng Chen et al.   ANALYST

Aptamer-Based Microfluidic Electrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers

(2016) Su Ryon Shin et al.   ANALYTICAL CHEMISTRY

Direct quantification of transendothelial electrical resistance in organs-on-chips

(2016) Marinke W. van der Helm et al.   BIOSENSORS & BIOELECTRONICS

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model

(2016) Hyuna Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Assessment of metabolism-dependent drug efficacy and toxicity on a multilayer organs-on-a-chip

(2016) Zhongyu Li et al.   Integrative Biology

Low-temperature bonding process for the fabrication of hybrid glass–membrane organ-on-a-chip devices

(2016) Kyall J. Pocock et al.   Journal of Micro-Nanolithography MEMS and MOEMS

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

(2016) Jacquelyn A. Brown et al.   Journal of Neuroinflammation

One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology

(2016) Hyungseok Lee et al.   LAB ON A CHIP

A vertical-flow bioreactor array compacts hepatocytes for enhanced polarity and functions

(2016) Liang Zhu et al.   LAB ON A CHIP

Microdroplet chain array for cell migration assays

(2016) Yan Ma et al.   LAB ON A CHIP

Interfacial geometry dictates cancer cell tumorigenicity

(2016) Junmin Lee et al.   NATURE MATERIALS

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

(2016) Danny Bavli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Reversibly Sealed, Easy Access, Modular (SEAM) Microfluidic Architecture to Establish In Vitro Tissue Interfaces

(2016) Vinay V. Abhyankar et al.   PLoS One

Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells

(2016) Andreas Reimer et al.   Scientific Reports

Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers

(2016) Reza Riahi et al.   Scientific Reports

Analysis of high-throughput screening reveals the effect of surface topographies on cellular morphology

(2015) Marc Hulsman et al.   Acta Biomaterialia

Liver sinusoid on a chip: Long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms

(2015) Young Bok Abraham Kang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

(2015) Ilka Maschmeyer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Tuning cell adhesion by direct nanostructuring silicon into cell repulsive/adhesive patterns

(2015) Priyatha Premnath et al.   EXPERIMENTAL CELL RESEARCH

Coupling between apical tension and basal adhesion allow epithelia to collectively sense and respond to substrate topography over long distances

(2015) Kyle E. Broaders et al.   Integrative Biology

A biologically inspired lung-on-a-chip device for the study of protein-induced lung inflammation

(2015) Tushar H. Punde et al.   Integrative Biology

Placenta-on-a-chip: a novel platform to study the biology of the human placenta

(2015) Ji Soo Lee et al.   Journal of Maternal-Fetal & Neonatal Medicine

Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

(2015) JiSoo Park et al.   LAB ON A CHIP

A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

(2015) Andreas O. Stucki et al.   LAB ON A CHIP

Multi-layered, membrane-integrated microfluidics based on replica molding of a thiol–ene epoxy thermoset for organ-on-a-chip applications

(2015) Drago Sticker et al.   LAB ON A CHIP

Matrix Stiffness and Nanoscale Spatial Organization of Cell-Adhesive Ligands Direct Stem Cell Fate

(2015) Kai Ye et al.   NANO LETTERS

Single-cell measurement of red blood cell oxygen affinity

(2015) Giuseppe Di Caprio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro

(2014) Massimo Marzorati et al.   BMC MICROBIOLOGY

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

A Novel Modular Bioreactor to In Vitro Study the Hepatic Sinusoid

(2014) Xavi Illa et al.   PLoS One

Engineering the Microstructure of Electrospun Fibrous Scaffolds by Microtopography

(2013) Qian Cheng et al.   BIOMACROMOLECULES

Salivary gland cell differentiation and organization on micropatterned PLGA nanofiber craters

(2013) David A. Soscia et al.   BIOMATERIALS

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans

(2013) Mijke Buitinga et al.   PLoS One

Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip

(2013) M. L. McCain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel three-dimensional Boyden chamber system for studying transendothelial transport

(2012) I. Hebeiss et al.   LAB ON A CHIP

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device

(2012) Dan Gao et al.   LAB ON A CHIP

Nanobionics: the impact of nanotechnology on implantable medical bionic devices

(2012) G. G. Wallace et al.   Nanoscale

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Controlling the porosity of fibrous scaffolds by modulating the fiber diameter and packing density

(2011) Sherif Soliman et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Fabrication of a transparent superamphiphobic coating with improved stability

(2011) Zhoukun He et al.   Soft Matter

Characterization of In Vitro Endothelial Linings Grown Within Microfluidic Channels

(2011) Mandy B. Esch et al.   TISSUE ENGINEERING PART A

Increasing the Pore Size of Electrospun Scaffolds

(2011) Jelena Rnjak-Kovacina et al.   TISSUE ENGINEERING PART B-REVIEWS

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Water Contact Angles on Poly(ethylene terephthalate) Film Exposed to Atmospheric Pressure Plasma

(2010) Keiko Gotoh et al.   JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY

Effect of Surface Wettability and Topography on the Adhesion of Osteosarcoma Cells on Plasma-modified Polystyrene

(2010) Denis P. Dowling et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Designing porosity and topography of poly(1,3-trimethylene carbonate) scaffolds

(2009) Bernke J. Papenburg et al.   Acta Biomaterialia

Surface modification of poly(lactic acid) by UV/Ozone irradiation

(2009) Gwang-Hoe Koo et al.   FIBERS AND POLYMERS

Surface topography induces 3D self-orientation of cells and extracellular matrix resulting in improved tissue function

(2009) Maxime D. Guillemette et al.   Integrative Biology

The effect of geometry on three-dimensional tissue growth

(2008) M. Rumpler et al.   Journal of the Royal Society Interface

Flexible fluidic microchips based on thermoformed and locally modified thin polymer films

(2008) R. Truckenmüller et al.   LAB ON A CHIP