Article
Engineering, Biomedical
Yongjie Jiao, Xiaojing Li, Xingxing Liu, Chaojing Li, Xiao Yang, Xuwei Sun, Fujun Wang, Lu Wang
Summary: This research successfully inhibits fibrosis caused by mechanical stimulation by using a scaffold inspired by cobwebs and introducing nano-protrusions. The inhibitory effect of fibrosis in a dynamic environment is verified through in vivo experiments.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Mechanics
Gemma Houston, Paolo Capobianchi, Monica S. N. Oliveira
Summary: In this study, the flow of miscible viscous fluid systems through microfluidic flow focusing devices was investigated using experiments and numerical simulations. The results showed that the characteristics of the central focused outlet stream were influenced by the fluid viscosity ratio and the inlet velocity ratio. It was also observed that the width of the central focused outlet stream decreased with both the velocity ratio and the viscosity ratio. Additionally, the study provided further insight into the curved interface in parallel flow systems with high viscosity contrasts, highlighting the influence of inlet viscosity ratio and microchannel aspect ratio on the interface curvature.
Review
Pharmacology & Pharmacy
Luca Eva Uhljar, Rita Ambrus
Summary: Electrospinning is a widely used technology for producing ultra-thin fibers. The morphology and physicochemical properties of the fibers depend on various factors. In the biomedical field, electrospun nanofibers have diverse applications, including medication delivery systems and tissue engineering scaffolds. The regulation of nanotechnology-made medical devices is still not properly defined. This review provides an overview of electrospinning and discusses developments in the field of electrospun medical devices, along with the relevant regulatory framework.
Article
Chemistry, Analytical
Yang Zhou, Jiao Wang, Ting Liu, Man Wu, Yuwei Lan, Chunping Jia, Jianlong Zhao
Summary: Microfluidic impedance cytometry is a label-free, low-cost and portable solution for cell analysis. A miniaturized flow cytometer based on a 3D hydrodynamic focusing mechanism is designed and characterized. The use of an adaptive sheath effectively concentrates the sample and increases the signal-to-noise ratio of the particle impedance pulse. The system showed accurate representation of the particle impedance characteristic distribution and can be conveniently used to monitor cell status.
Article
Biochemistry & Molecular Biology
Alireza Allafchian, Hamid Reza Masmouei, Seyed Amir Hossein Jalali
Summary: In this study, biocompatible electrospun nanofiber scaffolds were fabricated using Persian gum and poly (vinyl alcohol) to build an artificial extracellular matrix for cell growth. The results showed that scaffolds containing 50% Persian gum possessed the optimal cell compatibility, adhesion and proliferation properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Chemistry, Multidisciplinary
Atakan Tevlek, Seren Kecili, Ozge S. Ozcelik, Haluk Kulah, H. Cumhur Tekin
Summary: Two-dimensional (2D) cell culture lacks cell-cell and cell-extracellular matrix interactions, while three-dimensional (3D) cell culture methods enable equal transportation and mimic the in vivo conditions. Spheroids, self-assembled 3D cell aggregates, closely mimic the cell microenvironment and have important applications in medical and clinical research. Microfluidic methods provide rapid and precise fabrication of spheroids and allow for mimicking of the microenvironment-like in vivo conditions.
Article
Chemistry, Physical
Keshvad Shahrivar, Francesco Del Giudice
Summary: The encapsulation efficiency of particles in microfluidic devices can be improved by exploiting the phenomenon of particle train formation in viscoelastic liquids, allowing particles to approach the encapsulation area with a constant frequency synchronized to droplet formation. A simplified expression based on experimental results was developed to guide optimal design of microfluidic encapsulation systems. Additionally, experimental evidence of viscoelastic co-encapsulation of particles from different streams was reported for the first time.
Article
Engineering, Biomedical
Ziqi Gan, Yifan Zhao, Yeke Wu, Wei Yang, Zhihe Zhao, Lixing Zhao
Summary: Temporomandibular disorder (TMD) is a clinical challenge with limited therapeutic methods. We developed a biomimetic scaffold with optimal reinforcement, demonstrating its superior properties and potential for complex tissue regeneration in animal models.
ACTA BIOMATERIALIA
(2022)
Article
Biotechnology & Applied Microbiology
Andreas Struber, Georg Auer, Martin Fischlechner, Cody Wickstrom, Lisa Reiter, Eric Lutsch, Birgit Simon-Nobbe, Sabrina Marozin, Guenter Lepperdinger
Summary: This article describes a device and workflow for 3D cell model research. The device enables cell aggregation and online monitoring, while the workflow conserves resources and facilitates tracking and analysis of the cell aggregates. By providing detailed manufacturing instructions, this study promotes quick entry into 3D cell biology.
BIOENGINEERING-BASEL
(2022)
Article
Materials Science, Biomaterials
Claudia Mazio, Laura S. Scognamiglio, Roberta Passariello, Valeria Panzetta, Costantino Casale, Francesco Urciuolo, Luis J. V. Galietta, Giorgia Imparato, Paolo A. Netti
Summary: Cystic fibrosis is a common genetic disease that affects the respiratory system due to dysfunctional CFTR chloride channels. Researchers have developed an in vitro model on a chip to study the disease and guide treatment. The model successfully demonstrates the effects of dynamic flow on cilia distribution and mucus production, distinguishing between CF and non-CF epithelia. This model on a chip shows promise for studying CF and developing therapies.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Polymer Science
Rumeysa Bilginer, Dilce Ozkendir-Inanc, Umit Hakan Yildiz, Ahu Arslan-Yildiz
Summary: The study aimed to create propolis/PVA hybrid scaffold by electrospinning for 3D cell culture. Propolis enhanced biological properties of scaffold for cell attachment and proliferation, while electrospun nanofibers varied in size. The hybrid scaffold showed potential for cell culturing and tissue engineering.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Materials Science, Paper & Wood
Chen Feng, Ji-Ping Zhou, Xiao-Dong Xu, Ya-Ni Jiang, Hong-Can Shi, Guo-Qi Zhao
Summary: Three-dimensional printing (3DP) has gained extensive attention in the biomedical field, but scaffolds prepared solely by 3D bioprinting have limitations in mechanical properties and drug carrying capacity. Therefore, a new method combining 3D bioprinting and electrospinning is proposed to form 3D printed trachea composites, aiming to overcome these issues.
Article
Materials Science, Multidisciplinary
Jae Won Choi, Jisun Lee, Jeongho Yang, Young Won Kim, Suk Hee Park, Seokbeom Kim, Sukjoon Hong, Yong Son, Jisu Han, Cheol Woo Ha
Summary: 3D printing technology shows great potential in the field of microfluidics, where traditional 2D manufacturing techniques have limitations in the fabrication and usage of microfluidic chips. This study introduces a LEGO chip that can print 3D structured channels within a short timeframe, which can be utilized for producing bio-applicable devices for mass transfer in vivo.
ACS APPLIED POLYMER MATERIALS
(2021)
Review
Nanoscience & Nanotechnology
Abhimanyu Harshey, Alok Kumar, Akash Kumar, Tanurup Das, Kriti Nigam, Ankit Srivastava
Summary: Legally sound evidence is essential in criminal investigations. Paper-based microanalytical devices (mu PADs) have gained attention in forensic science due to their practicality and portability in on-site detection of physical evidence. These devices not only aid in collecting legally sound evidence but also help in apprehending potential offenders by detecting traces.
MICROFLUIDICS AND NANOFLUIDICS
(2023)
Article
Chemistry, Multidisciplinary
Emi Sano, Sayaka Deguchi, Naoki Matsuoka, Masahiro Tsuda, Mengyang Wang, Kaori Kosugi, Chihiro Mori, Keisuke Yagi, Aya Wada, Shinsuke Yamasaki, Tsuyoshi Kawai, Masahide Yodogawa, Hiroyuki Mizuguchi, Norihito Nakazawa, Fumiyoshi Yamashita, Yu-suke Torisawa, Kazuo Takayama
Summary: The study investigated the feasibility of using a FEPM-based hepatocyte chip with lower drug absorption for drug discovery research. The FEPM-based chip showed higher detection of drug metabolites and lower hepatocyte cytotoxicity compared to the PDMS-based chip, indicating its potential utility in drug metabolism and toxicity studies.
Article
Biotechnology & Applied Microbiology
Parin U. Kadakia, Emily A. Growney Kalaf, Andrew J. Dunn, Laurie P. Shornick, Scott A. Sell
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2018)
Article
Biochemical Research Methods
Chengpeng Chen, Alexandra D. Townsend, Elizabeth A. Hayter, Hannah M. Birk, Scott A. Sell, R. Scott Martin
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2018)
Article
Chemistry, Analytical
Akash S. Munshi, Chengpeng Chen, Alexandra D. Townsend, R. Scott Martin
ANALYTICAL METHODS
(2018)
Article
Engineering, Biomedical
Gabriel J. Haas, Andrew J. Dunn, Madison Marcinczyk, Muhamed Talovic, Mark Schwartz, Robert Scheidt, Anjali D. Patel, Katherine R. Hixon, Hady Elmashhady, Sarah H. McBride-Gagyi, Scott A. Sell, Koyal Garg
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Article
Engineering, Biomedical
Krishna H. Patel, Andrew J. Dunn, Muhamed Talovic, Gabriel J. Haas, Madison Marcinczyk, Hady Elmashhady, Emily Growney Kalaf, Scott A. Sell, Koyal Garg
BIOMEDICAL MATERIALS
(2019)
Article
Engineering, Biomedical
Genevieve Hilliard, Cory E. DeClue, Benjamin A. Minden-Birkenmaier, Andrew J. Dunn, Scott A. Sell, Laurie P. Shornick
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2019)
Article
Materials Science, Biomaterials
Mohammad Mehdi Kalani, Jhamak Nourmohammadi, Babak Negandari, Abdolrasol Rahimi, Scott A. Sell
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Giraso Keza Monia Kabandana, Curtis G. Jones, Sahra Khan Sharifi, Chengpeng Chen
Article
Engineering, Electrical & Electronic
Curtis G. Jones, Chengpeng Chen
SENSORS AND ACTUATORS A-PHYSICAL
(2020)
Article
Materials Science, Biomaterials
Tianjiao Huang, Curtis G. Jones, Jay H. Chung, Chengpeng Chen
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Materials Science, Biomaterials
Curtis G. Jones, Tianjiao Huang, Jay H. Chung, Chengpeng Chen
Summary: The dysfunction of endothelial cells plays a role in various pathologies, making in vitro endothelial cell models essential for pathophysiological and pharmaceutical studies. A modular microfluidic system using 3D printing and electrospinning was developed, enabling easy integration and switching of desired ECM topographies. This study reveals that the aligned fibrous topography on the ECM can increase nitric oxide production in endothelial cells, providing new insights for future research and modeling in this field.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Review
Chemistry, Analytical
Giraso Keza Monia Kabandana, Tao Zhang, Chengpeng Chen
Summary: This review paper examines recent advancements in 3D printed microfluidics, discussing three main 3D printing technologies and new emerging 3D-printing technologies. It analyzes their advantages, limitations, and potential applications in the field of microfluidics.
ANALYTICAL METHODS
(2022)
Article
Biochemical Research Methods
Yueli Liu, Laura E. Hesse, Morgan K. Geiger, Kurt R. Zinn, Timothy J. McMahon, Chengpeng Chen, Dana M. Spence
Summary: A set of 3D-printed analytical devices were developed to investigate the effects of different storage solutions on erythrocytes in transfusion medicine. The results showed that hyperglycemic conditions permanently alter erythrocyte deformability and reduce ATP release. However, normal glycemic storage can mitigate the storage lesion.
Article
Biochemical Research Methods
Giraso Keza Monia Kabandana, Adam Michael Ratajczak, Chengpeng Chen
Summary: The study presents a new technology for simple, fast, and robust assembly of customizable and scalable microfluidic devices with minimal facilities. This technology is broadly applicable to research that needs or could be enhanced by microfluidics.
Review
Materials Science, Biomaterials
John A. Terrell, Curtis G. Jones, Giraso Keza Monia Kabandana, Chengpeng Chen
JOURNAL OF MATERIALS CHEMISTRY B
(2020)