Strategies to increase nitric oxide signalling in cardiovascular disease

Vasculopathy and pulmonary hypertension in sickle cell disease

(2015) Karin P. Potoka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Interactions between cocoa flavanols and inorganic nitrate: Additive effects on endothelial function at achievable dietary amounts

(2015) Ana Rodriguez-Mateos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pitfalls in measuring NO bioavailability using NOx

(2015) Daniel B. Kim-Shapiro et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients

(2015) Michael J. Berry et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Antibacterial Mouthwash Blunts Oral Nitrate Reduction and Increases Blood Pressure in Treated Hypertensive Men and Women

(2014) Catherine P. Bondonno et al.   AMERICAN JOURNAL OF HYPERTENSION

Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury

(2014) Feng Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A new mechanism of action of thienopyridine antiplatelet drugs – A role for gastric nitrosthiol metabolism?

(2014) R.A. Anderson et al.   ATHEROSCLEROSIS

Vascular oxidative stress, nitric oxide and atherosclerosis

(2014) Huige Li et al.   ATHEROSCLEROSIS

Letter by Montenegro and Lundberg Regarding Article, “Unexpected Effect of Proton Pump Inhibitors: Elevation of the Cardiovascular Risk Factor Asymmetric Dimethylarginine”

(2014) Marcelo F. Montenegro et al.   CIRCULATION

Circulating Nitrite Contributes to Cardioprotection by Remote Ischemic Preconditioning

(2014) Tienush Rassaf et al.   CIRCULATION RESEARCH

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Nebulized Sodium Nitrite (AIR001) Following Repeat-Dose Inhalation in Healthy Subjects

(2014) Peter J. Rix et al.   CLINICAL PHARMACOKINETICS

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

(2014) N. Siddiqi et al.   EUROPEAN HEART JOURNAL

Nebivolol, But Not Metoprolol, Lowers Blood Pressure in Nitric Oxide–Sensitive Human Hypertension

(2014) Luis E. Okamoto et al.   HYPERTENSION

Mechanisms of Human Erythrocytic Bioactivation of Nitrite

(2014) Chen Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart

(2014) Tom Ashmore et al.   JOURNAL OF PHYSIOLOGY-LONDON

LDL cholesterol: controversies and future therapeutic directions

(2014) Paul M Ridker   LANCET

Targeting NOS as a therapeutic approach for heart failure

(2014) Lifei Tang et al.   PHARMACOLOGY & THERAPEUTICS

A Randomized Clinical Trial Testing the Anti-Inflammatory Effects of Preemptive Inhaled Nitric Oxide in Human Liver Transplantation

(2014) John D. Lang et al.   PLoS One

Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase

(2014) R. L. Charles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond

(2014) Robert Lukowski et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators

(2013) Markus Follmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel Aspects of Dietary Nitrate and Human Health

(2013) Eddie Weitzberg et al.   Annual Review of Nutrition

Redox-Dependent Anti-Inflammatory Signaling Actions of Unsaturated Fatty Acids

(2013) Meghan Delmastro-Greenwood et al.   Annual Review of Physiology

Direct sGC Activation Bypasses NO Scavenging Reactions of Intravascular Free Oxy-Hemoglobin and Limits Vasoconstriction

(2013) Nicolaas J.H. Raat et al.   ANTIOXIDANTS & REDOX SIGNALING

The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls

(2013) Eugenia Cifuentes-Pagano et al.   ANTIOXIDANTS & REDOX SIGNALING

Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?

(2013) John Pernow et al.   CARDIOVASCULAR RESEARCH

Unexpected Effect of Proton Pump Inhibitors

(2013) Yohannes T. Ghebremariam et al.   CIRCULATION

Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease

(2013) Huige Li et al.   CURRENT OPINION IN PHARMACOLOGY

Arginase inhibition reduces infarct size via nitric oxide, protein kinase C epsilon and mitochondrial ATP-dependent K+ channels

(2013) Yahor Tratsiakovich et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Enhanced Vasodilator Activity of Nitrite in Hypertension

(2013) Suborno M. Ghosh et al.   HYPERTENSION

Selective Recapitulation of Conserved and Nonconserved Regions of Putative NOXA1 Protein Activation Domain Confers Isoform-specific Inhibition of Nox1 Oxidase and Attenuation of Endothelial Cell Migration

(2013) Daniel J. Ranayhossaini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diminished Global Arginine Bioavailability as a Metabolic Defect in Chronic Systolic Heart Failure

(2013) W. H. Wilson Tang et al.   JOURNAL OF CARDIAC FAILURE

Safety and pharmacokinetics of sodium nitrite in patients with subarachnoid hemorrhage: a Phase IIA study

(2013) Edward H. Oldfield et al.   JOURNAL OF NEUROSURGERY

Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria

(2013) Chiaki Ito et al.   MOLECULAR CELL

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Riociguat for the Treatment of Pulmonary Arterial Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

The mitochondria as a target for cardioprotection in acute myocardial ischemia

(2013) Offir Ertracht et al.   PHARMACOLOGY & THERAPEUTICS

Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity

(2013) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sodium nitrite in patients with peripheral artery disease and diabetes mellitus: Safety, walking distance and endothelial function

(2013) Emile R Mohler et al.   VASCULAR MEDICINE

Adrenoreceptors and nitric oxide in the cardiovascular system

(2013) Valeria Conti et al.   Frontiers in Physiology

Arginase: The Emerging Therapeutic Target for Vascular Oxidative Stress and Inflammation

(2013) Zhihong Yang et al.   Frontiers in Immunology

Nitro-Fatty Acids: Formation, Redox Signaling, and Therapeutic Potential

(2012) Andrés Trostchansky et al.   ANTIOXIDANTS & REDOX SIGNALING

Angiotensin II, NADPH Oxidase, and Redox Signaling in the Vasculature

(2012) Aurelie Nguyen Dinh Cat et al.   ANTIOXIDANTS & REDOX SIGNALING

Dietary Nitrate Supplementation Improves Revascularization in Chronic Ischemia

(2012) Ulrike B. Hendgen-Cotta et al.   CIRCULATION

Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients With Coronary Artery Disease

(2012) Colin Cunnington et al.   CIRCULATION

Arginase Inhibition Improves Endothelial Function in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus

(2012) Alexey Shemyakin et al.   CIRCULATION

Dealcoholized Red Wine Decreases Systolic and Diastolic Blood Pressure and Increases Plasma Nitric Oxide

(2012) Gemma Chiva-Blanch et al.   CIRCULATION RESEARCH

Sildenafil Increases Digital Skin Blood Flow During All Phases of Local Cooling in Primary Raynaud's Phenomenon

(2012) M Roustit et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Ingested nitrate and nitrite and stomach cancer risk: An updated review

(2012) Nathan S. Bryan et al.   FOOD AND CHEMICAL TOXICOLOGY

Regulation of mitochondrial function and energetics by reactive nitrogen oxides

(2012) Filip J Larsen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increase in gastric pH reduces hypotensive effect of oral sodium nitrite in rats

(2012) Lucas C. Pinheiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary inorganic nitrate mobilizes circulating angiogenic cells

(2012) Christian Heiss et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physiological role for nitrate-reducing oral bacteria in blood pressure control

(2012) Vikas Kapil et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pepsin is nitrated in the rat stomach, acquiring antiulcerogenic activity: A novel interaction between dietary nitrate and gut proteins

(2012) Bárbara S. Rocha et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polyphenols decreased liver NADPH oxidase activity, increased muscle mitochondrial biogenesis and decreased gastrocnemius age-dependent autophagy in aged rats

(2012) Caroline Laurent et al.   FREE RADICAL RESEARCH

Benefits in Cognitive Function, Blood Pressure, and Insulin Resistance Through Cocoa Flavanol Consumption in Elderly Subjects With Mild Cognitive Impairment

(2012) Giovambattista Desideri et al.   HYPERTENSION

Endothelial Nitric-oxide Synthase Activation Generates an Inducible Nitric-oxide Synthase-like Output of Nitric Oxide in Inflamed Endothelium

(2012) Jessica L. Lowry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary nitrate increases tetanic [Ca2+]iand contractile force in mouse fast-twitch muscle

(2012) Andrés Hernández et al.   JOURNAL OF PHYSIOLOGY-LONDON

Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats

(2012) Scott K. Ferguson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nitric oxide caught in traffic

(2012) Mark T. Gladwin et al.   NATURE

Endothelial cell expression of haemoglobin α regulates nitric oxide signalling

(2012) Adam C. Straub et al.   NATURE

A comparison of organic and inorganic nitrates/nitrites

(2012) Sami A. Omar et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Local Arginase Inhibition during Early Reperfusion Mediates Cardioprotection via Increased Nitric Oxide Production

(2012) Adrian T. Gonon et al.   PLoS One

Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane

(2012) L. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitrate transport in salivary glands with implications for NO homeostasis

(2012) J. O. Lundberg   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of oral l-arginine supplementation on blood pressure: A meta-analysis of randomized, double-blind, placebo-controlled trials

(2011) Jia-Yi Dong et al.   AMERICAN HEART JOURNAL

Arginase inhibition restores in vivo coronary microvascular function in type 2 diabetic rats

(2011) Julia Grönros et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nitroglycerin-Induced Endothelial Dysfunction and Tolerance Involve Adverse Phosphorylation and S -Glutathionylation of Endothelial Nitric Oxide Synthase

(2011) Maike Knorr et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans

(2011) Filip J. Larsen et al.   Cell Metabolism

Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling

(2011) Charalambos Antoniades et al.   CIRCULATION

Soluble Guanylate Cyclase as an Emerging Therapeutic Target in Cardiopulmonary Disease

(2011) Johannes-Peter Stasch et al.   CIRCULATION

Dietary Nitrite in Nitric Oxide Biology: A Redox Interplay with Implications for Pathophysiology and Therapeutics

(2011) Barbara S. Rocha et al.   CURRENT DRUG TARGETS

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling

(2011) Imad Al Ghouleh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intragastric nitration by dietary nitrite: Implications for modulation of protein and lipid signaling

(2011) Bárbara S. Rocha et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decreased leukocyte recruitment by inorganic nitrate and nitrite in microvascular inflammation and NSAID-induced intestinal injury

(2011) Cecilia Jädert et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease

(2011) Aarti A. Kenjale et al.   JOURNAL OF APPLIED PHYSIOLOGY

Nitroalkenes Confer Acute Cardioprotection via Adenine Nucleotide Translocase 1

(2011) Sergiy M. Nadtochiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Vasoactive Properties of Thienopyridine-Derived Nitrosothiols

(2011) Shantu S. Bundhoo et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis

(2011) James Leiper et al.   NATURE REVIEWS DRUG DISCOVERY

Safety and Feasibility of Long-term Intravenous Sodium Nitrite Infusion in Healthy Volunteers

(2011) Ryszard M. Pluta et al.   PLoS One

Ischemic Postconditioning: From Receptor to End-Effector

(2010) Michael V. Cohen et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants: Molecules, medicines, and myths

(2010) John M.C. Gutteridge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New perspectives for the treatment of pulmonary hypertension

(2010) Reshma S Baliga et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension

(2010) Mattias Carlström et al.   CARDIOVASCULAR RESEARCH

Exercise and Physical Activity

(2010) Peter Kokkinos et al.   CIRCULATION

Feedback Control Through cGMP-Dependent Protein Kinase Contributes to Differential Regulation and Compartmentation of cGMP in Rat Cardiac Myocytes

(2010) Liliana R.V. Castro et al.   CIRCULATION RESEARCH

Glucocorticoids and the Cardiovascular System: State of the Art

(2010) Udi Nussinovitch et al.   CURRENT PHARMACEUTICAL DESIGN

Assessment of atherosclerosis: the role of flow-mediated dilatation

(2010) M. Charakida et al.   EUROPEAN HEART JOURNAL

Flavanols and cardiovascular disease prevention

(2010) C. Heiss et al.   EUROPEAN HEART JOURNAL

Corrigendum

(2010)   JOURNAL OF APPLIED PHYSIOLOGY

What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology

(2010) Bradford G. Hill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular Formation of Nitrite After Exercise Is Abolished in Patients With Cardiovascular Risk Factors and Coronary Artery Disease

(2010) Tienush Rassaf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice

(2010) Mattias Carlström et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2

(2009) Christine Y. Ivashchenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion

(2009) Volker Rudolph et al.   CARDIOVASCULAR RESEARCH

Arginase inhibition mediates cardioprotection during ischaemia-reperfusion

(2009) C. Jung et al.   CARDIOVASCULAR RESEARCH

Nitro-Fatty Acid Inhibition of Neointima Formation After Endoluminal Vessel Injury

(2009) Marsha P. Cole et al.   CIRCULATION RESEARCH

Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash

(2009) Joel Petersson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise

(2009) Filip J. Larsen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diminished Global Arginine Bioavailability and Increased Arginine Catabolism as Metabolic Profile of Increased Cardiovascular Risk

(2009) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Nitrite as regulator of hypoxic signaling in mammalian physiology

(2009) Ernst E. van Faassen et al.   MEDICINAL RESEARCH REVIEWS

Nitrate and nitrite in biology, nutrition and therapeutics

(2009) Jon O Lundberg et al.   Nature Chemical Biology

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effect of Physical Exercise on Endothelial Function

(2009) Samanta Di Francescomarino et al.   SPORTS MEDICINE

Bioavailability of sodium nitrite from an aqueous solution in healthy adults

(2009) Claudine C. Hunault et al.   TOXICOLOGY LETTERS

Synergy between Natriuretic Peptides and Phosphodiesterase 5 Inhibitors Ameliorates Pulmonary Arterial Hypertension

(2008) Reshma S. Baliga et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

How do dietary flavanols improve vascular function? A position paper

(2008) Tankred Schewe et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise

(2008) Thomas Lauer et al.   BASIC RESEARCH IN CARDIOLOGY

Cardiac Myocyte–Specific Expression of Inducible Nitric Oxide Synthase Protects Against Ischemia/Reperfusion Injury by Preventing Mitochondrial Permeability Transition

(2008) Matthew B. West et al.   CIRCULATION

AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats

(2008) Philip Wenzel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite

(2008) Andrew J. Webb et al.   HYPERTENSION

Sustained Benefits in Vascular Function Through Flavanol-Containing Cocoa in Medicated Diabetic Patients

(2008) Jan Balzer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Influence of Omeprazole on the Antiplatelet Action of Clopidogrel Associated With Aspirin

(2008) Martine Gilard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis

(2008) Emmelie Å Jansson et al.   Nature Chemical Biology

The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

(2008) Jon O. Lundberg et al.   NATURE REVIEWS DRUG DISCOVERY

Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy

(2008) M. Satoh et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash

(2008) Mirco Govoni et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury

(2008) U. B. Hendgen-Cotta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism

(2007) Edzard Schwedhelm et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Recent developments in nitric oxide donor drugs

(2007) M R Miller et al.   BRITISH JOURNAL OF PHARMACOLOGY