The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls

Redox Circuitries Driving Src Regulation

(2013) Elisa Giannoni et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4

(2013) Rafał Kozieł et al.   BIOCHEMICAL JOURNAL

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Loss of p47 phox Subunit Enhances Susceptibility to Biomechanical Stress and Heart Failure Because of Dysregulation of Cortactin and Actin Filaments

(2013) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

The NOX1/4 Inhibitor GKT136901 as Selective and Direct Scavenger of Peroxynitrite

(2013) S. Schildknecht et al.   CURRENT MEDICINAL CHEMISTRY

Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance-Related Endothelial Cell Dysfunction

(2013) P. Sukumar et al.   DIABETES

Effects of iodonium-class flavin dehydrogenase inhibitors on growth, reactive oxygen production, cell cycle progression, NADPH oxidase 1 levels, and gene expression in human colon cancer cells and xenografts

(2013) James H. Doroshow et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Model of Interaction between Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Apocynin Analogues by Docking Method

(2013) Jie Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease

(2013) Yves Gorin   KIDNEY INTERNATIONAL

Apocynin: Chemical and Biophysical Properties of a NADPH Oxidase Inhibitor

(2013) Maicon Petrônio et al.   MOLECULES

Characterisation of Nox4 Inhibitors from Edible Plants

(2013) Philipp Kofler et al.   PLANTA MEDICA

Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors

(2013) Eugenia Cifuentes-Pagano et al.   MedChemComm

Strategies Aimed at Nox4 Oxidase Inhibition Employing Peptides from Nox4 B-Loop and C-Terminus and p22phoxN-Terminus: An Elusive Target

(2013) Gábor Csányi et al.   International Journal of Hypertension

The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation

(2012) David E. Green et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Reciprocal Relationship Between Reactive Oxygen Species and Cyclooxygenase-2 and Vascular Dysfunction in Hypertension

(2012) Sonia Martínez-Revelles et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuroprotection After Stroke by Targeting NOX4 As a Source of Oxidative Stress

(2012) Kim A. Radermacher et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidase-Mediated Triggering of Inflammasome Activation in Mouse Podocytes and Glomeruli During Hyperhomocysteinemia

(2012) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases in Heart Failure: Poachers or Gamekeepers?

(2012) Min Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

The NADPH Oxidase Family and its Inhibitors

(2012) Paulina Kleniewska et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Divergent Effects of p47 phox Phosphorylation at S303-4 or S379 on Tumor Necrosis Factor-α Signaling via TRAF4 and MAPK in Endothelial Cells

(2012) Lei Teng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The novel NOX inhibitor 2-acetylphenothiazine impairs collagen-dependent thrombus formation in a GPVI-dependent manner

(2012) D Vara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular Mechanisms of Hypertension—Reactive Oxygen Species and Antioxidants: A Basic Science Update for the Clinician

(2012) Augusto C. Montezano et al.   CANADIAN JOURNAL OF CARDIOLOGY

Targeting NOX enzymes in pulmonary fibrosis

(2012) Louise Hecker et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or “All that you did and did not want to know about Nox inhibitory peptides”

(2012) Iris Dahan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Towards specific NADPH oxidase inhibition by small synthetic peptides

(2012) Jamel El-Benna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NOX enzymes: potential target for the treatment of acute lung injury

(2012) Stéphanie Carnesecchi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors

(2012) Michael J. Surace et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTS

(2012) Eugenia Cifuentes-Pagano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

(2012) Sebastian Altenhöfer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53–polo like kinase 2 (PLK-2) pathway

(2012) Ji Hae Kim et al.   CELLULAR SIGNALLING

Ebselen and Congeners Inhibit NADPH Oxidase 2-Dependent Superoxide Generation by Interrupting the Binding of Regulatory Subunits

(2012) Susan M.E. Smith et al.   CHEMISTRY & BIOLOGY

Rational Design of Small Molecule Inhibitors Targeting the Rac GTPase-p67phox Signaling Axis in Inflammation

(2012) Emily E. Bosco et al.   CHEMISTRY & BIOLOGY

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

(2012) Bernard Lassègue et al.   CIRCULATION RESEARCH

Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)

(2012) Qi-An Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

(2012) Tomonori Aoyama et al.   HEPATOLOGY

Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease

(2012) A. Valencia et al.   HUMAN MOLECULAR GENETICS

NOX5 in Human Spermatozoa

(2012) Boris Musset et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidases as a source of oxidative stress and molecular target in ischemia/reperfusion injury

(2012) Pamela W. M. Kleikers et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91 phox subunit of NADPH oxidase

(2012) Qingshan Wang et al.   Journal of Neuroinflammation

A novel synthetic compound, 3-amino-3-(4-fluoro-phenyl)-1H-quinoline-2,4-dione, inhibits cisplatin-induced hearing loss by the suppression of reactive oxygen species: In vitro and in vivo study

(2012) Y.S. Shin et al.   NEUROSCIENCE

Targeting NADPH oxidases in vascular pharmacology

(2012) Agata Schramm et al.   VASCULAR PHARMACOLOGY

NADPH Oxidase 1-Mediated Oxidative Stress Leads to Dopamine Neuron Death in Parkinson's Disease

(2011) Dong-Hee Choi et al.   ANTIOXIDANTS & REDOX SIGNALING

Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors

(2011) Francesca Gaggini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

(2011) Vincent Jaquet et al.   BRITISH JOURNAL OF PHARMACOLOGY

NADPH oxidase inhibitors: a patent review

(2011) Jung-Ae Kim et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

NADPH-oxidase activation and cognition in Alzheimer disease progression

(2011) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamins C and E: Beneficial effects from a mechanistic perspective

(2011) Maret G. Traber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling

(2011) Imad Al Ghouleh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2

(2011) Gábor Csányi et al.   FREE RADICAL BIOLOGY AND MEDICINE

NOX5: from basic biology to signaling and disease

(2011) Karen Bedard et al.   FREE RADICAL BIOLOGY AND MEDICINE

High-fat Diet Increases and the Polyphenol, S17834, Decreases Acetylation of the Sirtuin-1–dependent Lysine-382 on p53 and Apoptotic Signaling in Atherosclerotic Lesion–prone Aortic Endothelium of Normal Mice

(2011) Shanqin Xu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation

(2011) Gregory J. Gatto et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Peroxisome proliferator-activated receptor-γ activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress

(2011) Angela Martín et al.   JOURNAL OF HYPERTENSION

Inhibition of NADPH oxidase activation by peptides mapping within the dehydrogenase region of Nox2-A “peptide walking” study

(2011) Iris Dahan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

(2011) Sarah Garrido-Urbani et al.   PLoS One

Quantitative Proteomics Reveals Cellular Targets of Celastrol

(2011) Jakob Hansen et al.   PLoS One

A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells

(2010) Davide Gianni et al.   ACS Chemical Biology

Nifedipine, a Calcium-Channel Blocker, Attenuated Glucose Intolerance and White Adipose Tissue Dysfunction in Type 2 Diabetic KK-Ay Mice

(2010) M. Iwai et al.   AMERICAN JOURNAL OF HYPERTENSION

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nox Activator 1

(2010) Xi-Lin Niu et al.   CIRCULATION

Role of NADPH Oxidase in Endothelial Ischemia/Reperfusion Injury in Humans

(2010) Stavros P. Loukogeorgakis et al.   CIRCULATION

Isoform specific functions of Nox protein-derived reactive oxygen species in the vasculature

(2010) Katrin Schröder   CURRENT OPINION IN PHARMACOLOGY

Local arterial nanoparticle delivery of siRNA for NOX2 knockdown to prevent restenosis in an atherosclerotic rat model

(2010) J M Li et al.   GENE THERAPY

Reactive Oxygen Species, NADPH Oxidases, and Hypertension

(2010) Srinivasa Raju Datla et al.   HYPERTENSION

Reactive oxygen species and vascular biology: implications in human hypertension

(2010) Rhian M Touyz et al.   HYPERTENSION RESEARCH

NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis

(2010) Aleksandr E. Vendrov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of Adenosine A2AReceptor Attenuates Basal and Angiotensin II-induced ROS Production by Nox2 in Endothelial Cells

(2010) Sapna Thakur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-Molecule Inhibitors of NADPH Oxidase 4

(2010) Gábor Borbély et al.   JOURNAL OF MEDICINAL CHEMISTRY

NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn piglets

(2009) Kathleen E. Dennis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Nox5 and the Regulation of Cellular Function

(2009) David J.R. Fulton   ANTIOXIDANTS & REDOX SIGNALING

NOX Enzymes in the Central Nervous System: From Signaling to Disease

(2009) Silvia Sorce et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases

(2009) Thomas L. Leto et al.   ANTIOXIDANTS & REDOX SIGNALING

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

NOX and inflammation in the vascular adventitia

(2009) Gábor Csányi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats

(2009) Yu-Yan Fan et al.   JOURNAL OF HYPERTENSION

Regulation of TNF-induced oxygen radical production in human neutrophils: role of δ-PKC

(2009) Laurie E. Kilpatrick et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Oxidative Stress and Oxidative Damage in Carcinogenesis

(2009) James E. Klaunig et al.   TOXICOLOGIC PATHOLOGY

Platelet-derived growth factor BB stimulates vasculogenesis of embryonic stem cell-derived endothelial cells by calcium-mediated generation of reactive oxygen species

(2008) S. Lange et al.   CARDIOVASCULAR RESEARCH

Classical Inhibitors of NOX NAD(P)H Oxidases Are Not Specific

(2008) Elisabetta Aldieri et al.   CURRENT DRUG METABOLISM

NADPH Oxidases, Reactive Oxygen Species, and Hypertension: Clinical implications and therapeutic possibilities

(2008) T. M. Paravicini et al.   DIABETES CARE

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species

(2008) Hideki Sumimoto   FEBS Journal

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOX enzymes as novel targets for drug development

(2008) J. David Lambeth et al.   Seminars in Immunopathology

NOX enzymes in immuno-inflammatory pathologies

(2008) Karl-Heinz Krause et al.   Seminars in Immunopathology

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION