The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis

Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1

(2010) Matthew Lluis et al.   ChemMedChem

A Novel Loss-of-Function DDAH1 Promoter Polymorphism Is Associated With Increased Susceptibility to Thrombosis Stroke and Coronary Heart Disease

(2010) Hu Ding et al.   CIRCULATION RESEARCH

Vascular hyporesponsiveness to vasopressors in septic shock: from bench to bedside

(2010) B. Levy et al.   INTENSIVE CARE MEDICINE

Improvement of endothelial dysfunction in atherosclerotic rabbit aortas by ex vivo gene transferring of dimethylarginine dimethylaminohydrolase-2

(2010) Mei Feng et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Modulating the NO generating system from a medicinal chemistry perspective: Current trends and therapeutic options in cardiovascular disease

(2010) Dennis Schade et al.   PHARMACOLOGY & THERAPEUTICS

Sequence Variation in DDAH1 and DDAH2 Genes Is Strongly and Additively Associated with Serum ADMA Concentrations in Individuals with Type 2 Diabetes

(2010) Sotoodeh Abhary et al.   PLoS One

EFFECTS OF A SELECTIVE iNOS INHIBITOR VERSUS NOREPINEPHRINE IN THE TREATMENT OF SEPTIC SHOCK

(2010) Fuhong Su et al.   SHOCK

Adenoviral-mediated overexpression of DDAH improves vascular tone regulation

(2010) Belen Torondel et al.   VASCULAR MEDICINE

Ex vivo gene transferring of human dimethylarginine dimethylaminohydrolase-2 improved endothelial dysfunction in diabetic rat aortas and high glucose-treated endothelial cells

(2009) Chang-Wu Lu et al.   ATHEROSCLEROSIS

Developing Dual and Specific Inhibitors of Dimethylarginine Dimethylaminohydrolase-1 and Nitric Oxide Synthase: Toward a Targeted Polypharmacology To Control Nitric Oxide

(2009) Yun Wang et al.   BIOCHEMISTRY

Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death

(2009) Gregory J. Kato et al.   BRITISH JOURNAL OF HAEMATOLOGY

Vascular Endothelial-Specific Dimethylarginine Dimethylaminohydrolase-1–Deficient Mice Reveal That Vascular Endothelium Plays an Important Role in Removing Asymmetric Dimethylarginine

(2009) Xinli Hu et al.   CIRCULATION

Common genetic variation inDDAH2is associated with intracerebral haemorrhage in a Chinese population: a multi-centre case-control study in China

(2009) Yongyi Bai et al.   CLINICAL SCIENCE

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Asymmetrical Dimethylarginine Is Increased in Plasma and Decreased in Cerebrospinal Fluid of Patients with Alzheimer’s Disease

(2009) Sönke Arlt et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease

(2009) Carol Wadham et al.   Expert Opinion on Drug Metabolism & Toxicology

Role of Dimethylarginine Dimethylaminohydrolases in the Regulation of Endothelial Nitric Oxide Production

(2009) Arthur J. Pope et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Alanine-Glyoxylate Aminotransferase 2 Lowers Asymmetric Dimethylarginine and Protects from Inhibition of Nitric Oxide Production

(2009) Roman N. Rodionov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms

(2009) Ben Caplin et al.   KIDNEY INTERNATIONAL

Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a rat model of chronic kidney disease (CKD)

(2009) Seiji Ueda et al.   LIFE SCIENCES

Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality—An update on patient populations with a wide range of cardiovascular risk

(2009) Rainer H. Böger et al.   PHARMACOLOGICAL RESEARCH

From arginine methylation to ADMA: A novel mechanism with therapeutic potential in chronic lung diseases

(2009) Dariusz Zakrzewicz et al.   BMC Pulmonary Medicine

Asymmetric Dimethylarginine and Lipid Peroxidation Products in Early Autosomal Dominant Polycystic Kidney Disease

(2008) Dan Wang et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants

(2008) Paul D. Speer et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Dimethylarginine Dimethylaminohydrolase Overexpression Enhances Insulin Sensitivity

(2008) Karsten Sydow et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Structure–activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: Alkenyl-amidines as new leads

(2008) Jürke Kotthaus et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Increased plasma asymmetric dimethylarginine (ADMA) levels in retinal venous occlusive disease

(2008) Angelo Zinellu et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Relationship of asymmetric dimethylarginine with flow-mediated dilatation in subjects with newly detected severe hypercholesterolemia

(2008) L. Vladimirova-Kitova et al.   CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

Gene transfer of dimethylarginine dimethylaminohydrolase-2 improves the impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells induced by lysophosphatidylcholine

(2008) Mei Feng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Prominent Role of the Liver in the Elimination of Asymmetric Dimethylarginine (ADMA) and the Consequences of Impaired Hepatic Function

(2008) Milan C. Richir et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

ADMA Levels Correlate with Proteinuria, Secondary Amyloidosis, and Endothelial Dysfunction

(2008) M. I. Yilmaz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischaemia in the early phase of diabetic nephropathy

(2008) R. Shibata et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Neuronal nitric oxide synthase expression in glial tumors: correlation with malignancy and tumor proliferation

(2008) Necmettin Tanriover et al.   NEUROLOGICAL RESEARCH

The reemergence of nitric oxide and cancer

(2008) David A. Wink et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

First-trimester uterine artery resistance and maternal serum concentration of asymmetric dimethylarginine

(2008) F. Prefumo et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY