The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway

The Vitamin D3 analogue calcipotriol suppresses CpG-activated TLR9-MyD88 signalling in murine plasmacytoid dendritic cells

(2018) T. Suzuki et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Anti-inflammatory effects of flavonoids in neurodegenerative disorders

(2018) Carmela Spagnuolo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effects of Helicobacter pylori Treatment on Incidence of Gastric Cancer in Older Individuals

(2018) Wai K. Leung et al.   GASTROENTEROLOGY

Helicobacter pylorieradication treatment and the risk of gastric adenocarcinoma in a Western population

(2018) Eva Doorakkers et al.   GUT

Toll like receptor signaling pathway as a potential therapeutic target in colorectal cancer

(2018) Reyhaneh Moradi-Marjaneh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Resveratrol: An overview of its anti-cancer mechanisms

(2018) Mohamed Elshaer et al.   LIFE SCIENCES

Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling

(2018) Biqiong Ren et al.   ONCOLOGY REPORTS

Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives

(2018) Takanori Tsuda   Food & Function

Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review

(2018) Undurti N. Das   Journal of Advanced Research

Dual functional roles of the MyD88 signaling in colorectal cancer development

(2018) Lu Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

(2018) Yen-Chun Koh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TLR4/MyD88 signaling determines the metastatic potential of breast cancer cells

(2018) Kunlin Wu et al.   Molecular Medicine Reports

Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects

(2018) Denisse Bravo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Cancer Prevention and Therapy with Polyphenols: Sphingolipid-Mediated Mechanisms

(2018) Michele Dei Cas et al.   Nutrients

The functional and inflammatory response of brain endothelial cells to Toll-Like Receptor agonists

(2018) Rebecca H. Johnson et al.   Scientific Reports

The Role of Toll-Like Receptor in Inflammation and Tumor Immunity

(2018) Xiaohong Cen et al.   Frontiers in Pharmacology

Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury

(2017) Gaozhi Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Caffeic acid phenethyl ester attenuates lipopolysaccharide-stimulated proinflammatory responses in human gingival fibroblasts via NF-κB and PI3K/Akt signaling pathway

(2017) Lei Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Toll-like receptor stimulation in cancer: A pro- and anti-tumor double-edged sword

(2017) Marion Dajon et al.   IMMUNOBIOLOGY

Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE−/− mice

(2017) Min Feng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effect of the Association of Nonsteroidal Anti-inflammatory and Antibiotic Drugs on Antibiofilm Activity and pH of Calcium Hydroxide Pastes

(2017) Rafaela Pignatti de Freitas et al.   JOURNAL OF ENDODONTICS

Cathelicidins InhibitEscherichia coli–Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner

(2017) Maarten Coorens et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor-4 signaling pathway in aorta aging and diseases: “ its double nature ”

(2017) Carmela Rita Balistreri et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Plants of the Genus Zingiber as a Source of Bioactive Phytochemicals: From Tradition to Pharmacy

(2017) Mehdi Sharifi-Rad et al.   MOLECULES

Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell

(2017) Chi-Ming Liu et al.   MOLECULES

6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ

(2017) Qinghe Han et al.   Oncotarget

Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine

(2017) Yulin Zhang et al.   Chinese Medicine

Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-κB signaling pathway

(2016) Shobha Bhaskar et al.   CELLULAR IMMUNOLOGY

Cancer Therapy with Phytochemicals: Present and Future Perspectives

(2015) Muobarak J. Tuorkey   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Low-grade inflammation, diet composition and health: current research evidence and its translation

(2015) Anne M. Minihane et al.   BRITISH JOURNAL OF NUTRITION

Curcumin, an active component of turmeric (Curcuma longa), and its effects on health

(2015) Betül Kocaadam et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Berberine reduces Toll-like receptor-mediated macrophage migration by suppression of Src enhancement

(2015) Wei-Erh Cheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine Prevents Intestinal Mucosal Barrier Damage During Early Phase of Sepsis in Rat through the Toll-Like Receptors Signaling Pathway

(2015) Guo-xun Li et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia

(2014) Jin-Woo Jeong et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Epigallocatechin-3-gallate-mediated Tollip induction through the 67-kDa laminin receptor negatively regulating TLR4 signaling in endothelial cells

(2014) Eui-Baek Byun et al.   IMMUNOBIOLOGY

Curcumin attenuates inflammatory responses by suppressing TLR4-mediated NF-κB signaling pathway in lipopolysaccharide-induced mastitis in mice

(2014) Yunhe Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Innate Immunity in Sepsis Pathogenesis and Its Modulation: New Immunomodulatory Targets Revealed

(2014) V. Kumar et al.   JOURNAL OF CHEMOTHERAPY

Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1

(2014) Woo Seok Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury

(2014) Hai-tao Zhu et al.   Journal of Neuroinflammation

Berberine inhibits LPS-induced TF procoagulant activity and expression through NF-κB/p65, Akt and MAPK pathway in THP-1 cells

(2014) Meng-yu Gao et al.   Pharmacological Reports

Caffeic Acid Phenethyl Ester and Therapeutic Potentials

(2014) Ghulam Murtaza et al.   Biomed Research International

Toll-Like Receptors and Prostate Cancer

(2014) Shu Zhao et al.   Frontiers in Immunology

TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens

(2014) Ryan McClure et al.   Frontiers in Immunology

Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways

(2013) Zhe Meng et al.   ACTA PHARMACOLOGICA SINICA

Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2

(2013) Jung Eun Koo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tea and Health: Studies in Humans

(2013) Naghma Khan et al.   CURRENT PHARMACEUTICAL DESIGN

Attenuation of Proinflammatory Responses byS-[6]-Gingerol via Inhibition of ROS/NF-Kappa B/COX2 Activation in HuH7 Cells

(2013) Xiao-Hong Li et al.   Evidence-based Complementary and Alternative Medicine

Innate lymphoid cells: New paradigm in immunology of inflammation

(2013) Vijay Kumar   IMMUNOLOGY LETTERS

Genistein inhibits TNF-α-induced endothelial inflammation through the protein kinase pathway A and improves vascular inflammation in C57BL/6 mice

(2013) Zhenquan Jia et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

(−)-Epigallocatechin-3-gallate blocks nicotine-induced matrix metalloproteinase-9 expression and invasiveness via suppression of NF-κB and AP-1 in endothelial cells

(2013) PHAM NGOC KHOI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Berberine Ameliorates Chronic Kidney Injury Caused by Atherosclerotic Renovascular Disease through the Suppression of NFκB Signaling Pathway in Rats

(2013) Xin Wan et al.   PLoS One

REVIEWING AND IDENTIFYING AMINO ACIDS OF HUMAN, MURINE, CANINE AND EQUINE TLR4 / MD-2 RECEPTOR COMPLEXES CONFERRING ENDOTOXIC INNATE IMMUNITY ACTIVATION BY LPS/LIPID A, OR ANTAGONISTIC EFFECTS BY ERITORAN, IN CONTRAST TO SPECIES-DEPENDENT MODULATION BY LIPID IVA

(2013) Thomas Scior et al.   Computational and Structural Biotechnology Journal

Inhibition of LPS binding to MD-2 co-receptor for suppressing TLR4-mediated expression of inflammatory cytokine by 1-dehydro-10-gingerdione from dietary ginger

(2012) Sun Hong Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress

(2012) So Young Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-inflammatory effects of resveratrol occur via inhibition of lipopolysaccharide-induced NF-κB activation in Caco-2 and SW480 human colon cancer cells

(2012) Maria Antonietta Panaro et al.   BRITISH JOURNAL OF NUTRITION

1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes

(2012) Hwa Young Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Suppression of Toll-like receptor 4 activation by caffeic acid phenethyl ester is mediated by interference of LPS binding to MD2

(2012) So Young Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinaleRoscoe)

(2012) I. Rahath Kubra et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells

(2012) Ya-Yun Hsu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Anti-inflammatory activity of lipophilic epigallocatechin gallate (EGCG) derivatives in LPS-stimulated murine macrophages

(2012) Ying Zhong et al.   FOOD CHEMISTRY

Reduced expression of Toll-like receptor 4 inhibits human breast cancer cells proliferation and inflammatory cytokines secretion

(2012) Huan Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Positive and negative regulation of insulin action by genistein in the endothelium

(2012) Xuejiao Gao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

TRAF6 is functional in inhibition of TLR4-mediated NF-κB activation by resveratrol

(2012) Peter B. Jakus et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcumin Improves TNBS-Induced Colitis in Rats by Inhibiting IL-27 Expression via the TLR4/NF-κB Signaling Pathway

(2012) Zhaojing Zeng et al.   PLANTA MEDICA

Modulation of NF-κB activation by resveratrol in LPS treated human intestinal cells results in downregulation of PGE2 production and COX-2 expression

(2012) Antonia Cianciulli et al.   TOXICOLOGY IN VITRO

Management of the Immune Reconstitution Inflammatory Syndrome

(2012) Graeme Meintjes et al.   Current HIV/AIDS Reports

Luteolin attenuates the pulmonary inflammatory response involves abilities of antioxidation and inhibition of MAPK and NFκB pathways in mice with endotoxin-induced acute lung injury

(2011) Min-Yung Kuo et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant and inhibitory effect of red ginger (Zingiber officinale var. Rubra) and white ginger (Zingiber officinale Roscoe) on Fe2+ induced lipid peroxidation in rat brain in vitro

(2010) Ganiyu Oboh et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Identification and functions of pattern-recognition receptors

(2010) Yutaro Kumagai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TLR4 Signaling Inhibitory Pathway Induced by Green Tea Polyphenol Epigallocatechin-3-Gallate through 67-kDa Laminin Receptor

(2010) E. Hong Byun et al.   JOURNAL OF IMMUNOLOGY

Soy isoflavones, diet and physical exercise modify serum cytokines in healthy obese postmenopausal women

(2010) Placido Llaneza et al.   PHYTOMEDICINE

Protective effect of resveratrol against LPS-induced extracellular lipoperoxidation in AR42J cells partly via a Myd88-dependent signaling pathway

(2009) Hichem Sebai et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin

(2009) Jun Kyung Lee et al.   BIOCHEMICAL PHARMACOLOGY

TBK1-Targeted Suppression of TRIF-Dependent Signaling Pathway of Toll-Like Receptors by 6-Shogaol, an Active Component of Ginger

(2009) Se-Jeong PARK et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells

(2009) Li-Chieh Wang et al.   BMC IMMUNOLOGY

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Sulforaphane Suppresses Oligomerization of TLR4 in a Thiol-Dependent Manner

(2009) Hyung Sun Youn et al.   JOURNAL OF IMMUNOLOGY

Inhibition of homodimerization of toll-like receptor 4 by 6-shogaol

(2009) Sang-Il Ahn et al.   MOLECULES AND CELLS

The role of TLRs, NLRs and RLRs in mucosal innate immunity and homeostasis

(2009) E C Lavelle et al.   Mucosal Immunology

Protective Role of Toll-like Receptor 4 during the Initiation Stage of Cutaneous Chemical Carcinogenesis

(2008) N. Yusuf et al.   CANCER RESEARCH

The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages

(2008) Paola Allavena et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Differential anti-inflammatory pathway by xanthohumol in IFN-γ and LPS-activated macrophages

(2008) Young-Chang Cho et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages

(2008) Min-Hsiung Pan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Modulation of Macrophage Functions by Compounds Isolated fromZingiber officinale

(2008) Eun Koh et al.   PLANTA MEDICA