Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

3D-printed IFN-γ-loading calcium silicate-β-tricalcium phosphate scaffold sequentially activates M1 and M2 polarization of macrophages to promote vascularization of tissue engineering bone

(2018) Tao Li et al.   Acta Biomaterialia

Role of microglia M1/M2 polarisation in the paraventricular nucleus: New insight into the development of stress-induced hypertension in rats

(2018) Yang Mi et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Adipose-derived stem cells ameliorate colitis by suppression of inflammasome formation and regulation of M1-macrophage population through prostaglandin E2

(2018) Hong Jun Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypertonic saline regulates microglial M2 polarization via miR-200b/KLF4 in cerebral edema treatment

(2018) Miaoyun Wen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization

(2018) Hong Lu et al.   BIOCHEMICAL PHARMACOLOGY

Treatment targets for M2 microglia polarization in ischemic stroke

(2018) Ji wang et al.   BIOMEDICINE & PHARMACOTHERAPY

M2 polarization of macrophages by Oncostatin M in hypoxic tumor microenvironment is mediated by mTORC2 and promotes tumor growth and metastasis

(2018) Richa Shrivastava et al.   CYTOKINE

Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression

(2018) Takayuki Okamoto et al.   EXPERIMENTAL CELL RESEARCH

LZ205, a newly synthesized flavonoid compound, exerts anti-inflammatory effect by inhibiting M1 macrophage polarization through regulating PI3K/AKT/mTOR signaling pathway

(2018) Dongsheng Bai et al.   EXPERIMENTAL CELL RESEARCH

The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2

(2018) Dimitry A. Chistiakov et al.   IMMUNOBIOLOGY

Targeting RAW 264.7 macrophages (M1 type) with Withaferin-A decorated mannosylated liposomes induces repolarization via downregulation of NF-κB and controlled elevation of STAT-3

(2018) Manoj Kumar Neog et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

miRNA regulation of macrophage M1/M2 polarization of Kupffer cells and PBMCs in alcoholic liver disease

(2018) A. Kim et al.   JOURNAL OF HEPATOLOGY

The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis

(2018) Fengna Chu et al.   JOURNAL OF NEUROIMMUNOLOGY

Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy

(2018) Dekun Wang et al.   KIDNEY INTERNATIONAL

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer

(2018) Huimin Lu et al.   MATRIX BIOLOGY

miR-330-5p/Tim-3 axis regulates macrophage M2 polarization and insulin resistance in diabetes mice

(2018) Jiling Sun et al.   MOLECULAR IMMUNOLOGY

M1/M2 macrophages induce chondral MMP/ADAMTS enzyme secretion in a direct co-culture experiment

(2018) N. Rosshirt et al.   OSTEOARTHRITIS AND CARTILAGE

The effect of pancreatic cancer patient derived serum on macrophage M1/M2 polarization

(2018) Matilda Juusola et al.   PANCREATOLOGY

Regulation of M1/M2 macrophage polarization by Sutherlandia frutescens via NFkB and MAPK signaling pathways

(2018) N. Camille et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Tumour-associated macrophages: Relation with progression and invasiveness, and assessment of M1/M2 macrophages in canine mammary tumours

(2018) L.N. Monteiro et al.   VETERINARY JOURNAL

Ginsenoside Rg 3 promotes inflammation resolution through M2 macrophage polarization

(2018) Saeromi Kang et al.   Journal of Ginseng Research

Hyperglycemia induces mixed M1/M2 cytokine profile in primary human monocyte-derived macrophages

(2017) Kondaiah Moganti et al.   IMMUNOBIOLOGY

Glycolysis regulates LPS-induced cytokine production in M2 polarized human macrophages

(2017) Sayako Chiba et al.   IMMUNOLOGY LETTERS

Diosgenin glucoside provides neuroprotection by regulating microglial M1 polarization

(2017) Shaoxia Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

(+)-Borneol improves the efficacy of edaravone against DSS-induced colitis by promoting M2 macrophages polarization via JAK2-STAT3 signaling pathway

(2017) Xiong Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model

(2017) Roya Aryanpour et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

4-Methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to Toll-like receptor of macrophages and M1 macrophage polarization

(2017) Hyo-Min Jang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke

(2017) Masato Kanazawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice

(2017) Peng-Fei Ma et al.   JOURNAL OF HEPATOLOGY

Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway

(2017) Jingkao Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

M2 Monocyte Microparticles Are Increased in Intracerebral Hemorrhage

(2017) Kyle B. Walsh et al.   Journal of Stroke & Cerebrovascular Diseases

M2 macrophages infusion ameliorates obesity and insulin resistance by remodeling inflammatory/macrophages' homeostasis in obese mice

(2017) Qi Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Sevoflurane suppresses microglial M2 polarization

(2017) Zengyang Pei et al.   NEUROSCIENCE LETTERS

Expression of iNOS, CD163 and ARG-1 taken as M1 and M2 markers of microglial polarization in human glioblastoma and the surrounding normal parenchyma

(2017) L. Lisi et al.   NEUROSCIENCE LETTERS

Macrophage function in obesity-induced inflammation and insulin resistance

(2017) Mario A. R. Lauterbach et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis

(2017) Yong-Hyun Han et al.   Cell Reports

M2 Monocyte Microparticles Are Increased in Intracerebral Hemorrhage

(2017) Kyle B. Walsh et al.   Journal of Stroke & Cerebrovascular Diseases

Macrophages and bone inflammation

(2017) Qiaoli Gu et al.   Journal of Orthopaedic Translation

Irgm1 promotes M1 but not M2 macrophage polarization in atherosclerosis pathogenesis and development

(2016) Shaohong Fang et al.   ATHEROSCLEROSIS

Anthocyanin effects on microglia M1/M2 phenotype: Consequence on neuronal fractalkine expression

(2016) Manuela Meireles et al.   BEHAVIOURAL BRAIN RESEARCH

Cannabinoid receptor-2 stimulation suppresses neuroinflammation by regulating microglial M1/M2 polarization through the cAMP/PKA pathway in an experimental GMH rat model

(2016) Yihao Tao et al.   BRAIN BEHAVIOR AND IMMUNITY

NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

(2016) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

M1-/M2-macrophage polarization in pseudolobules consisting of adipohilin-rich hepatocytes in thioacetamide (TAA)-induced rat hepatic cirrhosis

(2016) Kavindra Kumara Wijesundera et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Baicalin ameliorates experimental inflammatory bowel disease through polarization of macrophages to an M2 phenotype

(2016) Wei Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isomeranzin suppresses inflammation by inhibiting M1 macrophage polarization through the NF-κB and ERK pathway

(2016) Ge Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The pentacyclic triterpene Lupeol switches M1 macrophages to M2 and ameliorates experimental inflammatory bowel disease

(2016) Yeshan Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications

(2016) Mario Moisés Alvarez et al.   JOURNAL OF CONTROLLED RELEASE

Cardiac fibroblast cytokine profiles induced by proinflammatory or profibrotic stimuli promote monocyte recruitment and modulate macrophage M1/M2 balance in vitro

(2016) Claudio Humeres et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sinomenine enhances microglia M2 polarization and attenuates inflammatory injury in intracerebral hemorrhage

(2016) Hui Shi et al.   JOURNAL OF NEUROIMMUNOLOGY

Maternal low protein diet leads to placental angiogenic compensation via dysregulated M1/M2 macrophages and TNFα expression in Sprague-Dawley rats

(2016) Emilie Vomhof-DeKrey et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Aryl hydrocarbon receptor influences nitric oxide and arginine production and alters M1/M2 macrophage polarization

(2016) Samantha Climaco-Arvizu et al.   LIFE SCIENCES

Melanoma exosome induction of endothelial cell GM-CSF in pre-metastatic lymph nodes may result in different M1 and M2 macrophage mediated angiogenic processes

(2016) Joshua L. Hood   MEDICAL HYPOTHESES

Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage

(2016) Zhen Zhang et al.   MOLECULAR NEUROBIOLOGY

M1 and M2 macrophage recruitment during tendon regeneration induced by amniotic epithelial cell allotransplantation in ovine

(2016) Annunziata Mauro et al.   RESEARCH IN VETERINARY SCIENCE

miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα

(2016) Jia Bi et al.   Molecular Therapy-Nucleic Acids

Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization

(2016) Xiujing Feng et al.   EBioMedicine

Curcumin retunes cholesterol transport homeostasis and inflammation response in M1 macrophage to prevent atherosclerosis

(2015) Fang-Yuan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds

(2015) Kara L. Spiller et al.   BIOMATERIALS

Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages

(2015) Xingwei Jiang et al.   CLINICAL IMMUNOLOGY

M1-/M2-macrophages contribute to the development of GST-P-positive preneoplastic lesions in chemically-induced rat cirrhosis

(2015) Kavindra Kumara Wijesundera et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages

(2015) James P. Barrett et al.   EXPERIMENTAL CELL RESEARCH

Vibrio cholerae porin OmpU mediates M1-polarization of macrophages/monocytes via TLR1/TLR2 activation

(2015) Junaid Khan et al.   IMMUNOBIOLOGY

Selective modulation of microglia polarization to M2 phenotype for stroke treatment

(2015) Cong-Yuan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13

(2015) Shanshan Gao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Temporal profile of M1 and M2 responses in the hippocampus following early 24h of neurotrauma

(2015) Mubeen A. Ansari   JOURNAL OF THE NEUROLOGICAL SCIENCES

M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?

(2015) M.S. Moehle et al.   NEUROSCIENCE

Fluoxetine and S-citalopram inhibit M1 activation and promote M2 activation of microglia in vitro

(2015) F. Su et al.   NEUROSCIENCE

Pentamethoxyflavanone regulates macrophage polarization and ameliorates sepsis in mice

(2014) Lili Feng et al.   BIOCHEMICAL PHARMACOLOGY

Chrysin attenuates inflammation by regulating M1/M2 status via activating PPARγ

(2014) Xiujing Feng et al.   BIOCHEMICAL PHARMACOLOGY

Pharmacological modulation of monocytes and macrophages

(2014) Alberto Mantovani et al.   CURRENT OPINION IN PHARMACOLOGY

Macrophage Polarization in Inflammatory Diseases

(2014) Yan-Cun Liu et al.   International Journal of Biological Sciences

The Role of Macrophage Polarization in Infectious and Inflammatory Diseases

(2014) Adam C. Labonte et al.   MOLECULES AND CELLS

Theaflavin-3, 3′-digallate, a black tea polyphenol, attenuates adipocyte-activated inflammatory response of macrophage associated with the switch of M1/M2-like phenotype

(2014) Huey-Jiun Ko et al.   Journal of Functional Foods

Macrophage-Mediated Inflammatory Disorders

(2013) I-Ming Jou et al.   MEDIATORS OF INFLAMMATION

Hemarthrosis in hemophilic mice results in alterations in M1-M2 monocyte/macrophage polarization

(2013) Laurens Nieuwenhuizen et al.   THROMBOSIS RESEARCH

The inflammation highway: metabolism accelerates inflammatory traffic in obesity

(2012) Amy R. Johnson et al.   IMMUNOLOGICAL REVIEWS

Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolution

(2012) Eric S White et al.   JOURNAL OF PATHOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE