Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine

Pulsatilla Saponin D Inhibits Autophagic Flux and Synergistically Enhances the Anticancer Activity of Chemotherapeutic Agents Against HeLa Cells

(2015) Yulin Zhang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Berberine Increases Doxorubicin Sensitivity by Suppressing STAT3 in Lung Cancer

(2015) Ting Zhu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Migration and Invasion of Cancer Cells by Suppressing TGF-β1 Pathway

(2015) Tiantian She et al.   PLoS One

Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway

(2015) Xuan Liu et al.   PLoS One

Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway

(2014) Runfa Bao et al.   BMC CANCER

Baicalein Reduces the Invasion of Glioma Cells via Reducing the Activity of p38 Signaling Pathway

(2014) Zhenni Zhang et al.   PLoS One

Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression

(2013) Chi Zhang et al.   ACTA OTO-LARYNGOLOGICA

Oridonin Induces Apoptosis, Inhibits Migration and Invasion on Highly-Metastatic Human Breast Cancer Cells

(2013) Shengpeng Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Synergistic induction of apoptosis in A549 cells by dihydroartemisinin and gemcitabine

(2013) Chubiao Zhao et al.   APOPTOSIS

2-Hydroxy-3-methylanthraquinone from Hedyotis diffusa Willd induces apoptosis in human leukemic U937 cells through modulation of MAPK pathways

(2013) Nan Wang et al.   ARCHIVES OF PHARMACAL RESEARCH

Berberine combined with 2-deoxy-d-glucose synergistically enhances cancer cell proliferation inhibition via energy depletion and unfolded protein response disruption

(2013) Li-xia Fan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts

(2013) Chi Man Tsang et al.   BMC CANCER

Anti-angiogenic effect of the total flavonoids in Scutellaria barbata D. Don

(2013) Zhi-Jun Dai et al.   BMC Complementary and Alternative Medicine

Dihydroartemisinin induces apoptosis of cervical cancer cells via upregulation of RKIP and downregulation of bcl-2

(2013) Chun-jie Hu et al.   CANCER BIOLOGY & THERAPY

First-in-human phase II trial of the botanical formulation PHY906 with capecitabine as second-line therapy in patients with advanced pancreatic cancer

(2013) Muhammad Wasif Saif et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Dihydroartemisinin induces autophagy by suppressing NF-κB activation

(2013) Wei Hu et al.   CANCER LETTERS

SB365, Pulsatilla saponin D, targets c-Met and exerts antiangiogenic and antitumor activities

(2013) Sang-Won Hong et al.   CARCINOGENESIS

Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways

(2013) Jiumao Lin et al.   INTEGRATIVE CANCER THERAPIES

Chemical and preclinical studies onHedyotis diffusawith anticancer potential

(2013) Yu Niu et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling

(2013) Junfang Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The complexity of medicinal plants: The traditional Artemisia annua formulation, current status and future perspectives

(2013) Frank van der Kooy et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inhibition of c-Met promoted apoptosis, autophagy and loss of the mitochondrial transmembrane potential in oridonin-induced A549 lung cancer cells

(2013) Ying Liu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Anti-cancer mechanisms of clinically acceptable colchicine concentrations on hepatocellular carcinoma

(2013) Zu-Yau Lin et al.   LIFE SCIENCES

Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro

(2013) Zhi-Jun Dai et al.   MOLECULES

Artemisinins: Pharmacological actions beyond anti-malarial

(2013) Wanxing Eugene Ho et al.   PHARMACOLOGY & THERAPEUTICS

Scutellaria barbata D. Don extract synergizes the antitumor effects of low dose 5-fluorouracil through induction of apoptosis and metabolism

(2013) Huanli Xu et al.   PHYTOMEDICINE

Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein

(2013) Xiuming Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway

(2013) Ke-Wang Sun   WORLD JOURNAL OF GASTROENTEROLOGY

Berberine: New perspectives for old remedies

(2012) Micol Tillhon et al.   BIOCHEMICAL PHARMACOLOGY

Baicalein Inhibits DMBA/TPA-Induced Skin Tumorigenesis in Mice by Modulating Proliferation, Apoptosis, and Inflammation

(2012) Guo-Zhang Ma et al.   INFLAMMATION

Antioxidant and Immunity Activities of Fufang Kushen Injection Liquid

(2012) Shen-Kang Zhou et al.   MOLECULES

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Pro-apoptotic effects of tectorigenin on human hepatocellular carcinoma HepG2 cells

(2012) Chun-Ping Jiang   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells

(2012) Chengwei He et al.   Chinese Medicine

Clarification of the Phenotypic Characteristics and Anti-Tumor Activity of Hedyotis diffusa

(2011) Hong-Zin Lee et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes

(2011) Antony S. Tin et al.   ANTI-CANCER DRUGS

Autophagy enhanced phagocytosis of apoptotic cells by oridonin-treated human histocytic lymphoma U937 cells

(2011) Linghe Zang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway

(2011) Ning Gao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63

(2011) Shu-Er Chow et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Qualitative analysis of the chemical constituents inHedyotis diffusaby HPLC-TOF-MS

(2011) Xu Wang et al.   NATURAL PRODUCT RESEARCH

Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1

(2011) G Polier et al.   Cell Death & Disease

Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway

(2010) Jeevitha B. Patil et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GenusBupleurum: a review of its phytochemistry, pharmacology and modes of action

(2010) Mohamed L. Ashour et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies

(2010) M. Wasif Saif et al.   PHYTOMEDICINE

Proteomic identification of proteins involved in the anticancer activities of oridonin in HepG2 cells

(2010) Hui Wang et al.   PHYTOMEDICINE

Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells

(2010) Tan Weifeng et al.   PHYTOMEDICINE

Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolism

(2010) Qing Zhao et al.   TOXICOLOGY LETTERS

Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy

(2010) Jun-Qiang Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqi Tang (HQT) and PHY906

(2010) Robert Tilton et al.   Chinese Medicine

Inhibition of P-Glycoprotein by Wogonin Is Involved with the Potentiation of Etoposide-Induced Apoptosis in Cancer Cells

(2009) Eibai Lee et al.   Annals of the New York Academy of Sciences

Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1α and P-glycoprotein overexpression

(2009) C Riganti et al.   BRITISH JOURNAL OF PHARMACOLOGY

The combination of berberine and irradiation enhances anti-cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells

(2009) Jung-Mu Hur et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations

(2009) Jun Tang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Methylanthraquinone from Hedyotis diffusa WILLD induces Ca2+-mediated apoptosis in human breast cancer cells

(2009) Zheng Liu et al.   TOXICOLOGY IN VITRO

Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells

(2008) Jing Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy

(2008) Tao Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Huang-lian-jie-du-tang, a traditional Chinese medicine prescription, induces cell-cycle arrest and apoptosis in human liver cancer cellsin vitroandin vivo

(2008) Ya-Ling Hsu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY