Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes

Modulating protein–protein interactions: the potential of peptides

(2015) Laura Nevola et al.   CHEMICAL COMMUNICATIONS

Multivalent helix mimetics for PPI-inhibition

(2015) Anna Barnard et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cobalt-Catalyzed Directed Alkylation of Olefinic C–H Bond with Primary and Secondary Alkyl Chlorides

(2015) Naohiko Yoshikai et al.   SYNLETT

Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers

(2015) Valeria Azzarito et al.   Chemical Science

Towards understanding cell penetration by stapled peptides

(2015) Qian Chu et al.   MedChemComm

Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein–Helix Interaction

(2014) Christopher H. Douse et al.   ACS Chemical Biology

Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides

(2014) Yuxiao Wang et al.   ACS Chemical Biology

Genetically Encoding an Electrophilic Amino Acid for Protein Stapling and Covalent Binding to Native Receptors

(2014) Xiao-Hua Chen et al.   ACS Chemical Biology

Diphenylacetylene-Linked Peptide Strands Induce Bidirectional β-Sheet Formation

(2014) Hannah Lingard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Multifaceted Secondary Structure Mimic Based On Piperidine-piperidinones

(2014) Dongyue Xin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Constraining Cyclic Peptides To Mimic Protein Structure Motifs

(2014) Timothy A. Hill et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Targeting of Rab-GTPase-Effector Interactions

(2014) Jochen Spiegel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Comparative α-Helicity of Cyclic Pentapeptides in Water

(2014) Aline D. de Araujo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Constrained Peptides with Target-Adapted Cross-Links as Inhibitors of a Pathogenic Protein-Protein Interaction

(2014) Adrian Glas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of antiviral stapled peptides containing a biphenyl cross-linker

(2014) Avinash Muppidi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Two-Face, Two-Turn α-Helix Mimetics Based on a Cross-Acridine Scaffold: Analogues of the Bim BH3 Domain

(2014) Xiangqian Li et al.   CHEMBIOCHEM

The Cyclic Cystine Ladder of Theta-Defensins as a Stable, Bifunctional Scaffold: A Proof-of-Concept Study Using the Integrin-Binding RGD Motif.

(2014) Anne C. Conibear et al.   CHEMBIOCHEM

Small-Molecule Proteomimetic Inhibitors of the HIF-1α-p300 Protein-Protein Interaction

(2014) George M. Burslem et al.   CHEMBIOCHEM

Linear Aliphatic Dialkynes as Alternative Linkers for Double-Click Stapling of p53-Derived Peptides

(2014) Yu Heng Lau et al.   CHEMBIOCHEM

Modulators of Protein–Protein Interactions

(2014) Lech-Gustav Milroy et al.   CHEMICAL REVIEWS

Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure

(2014) Udaya Kiran Marelli et al.   CHEMISTRY-A EUROPEAN JOURNAL

Focused chemical libraries – design and enrichment: an example of protein–protein interaction chemical space

(2014) Xu Zhang et al.   Future Medicinal Chemistry

Administration strategies for proteins and peptides

(2014) D. Ibraheem et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection

(2014) Gregory H. Bird et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A

(2014) Andreas O. Frank et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Improvement of the Affinity and Selectivity of Integrin Binding of Grafted Lasso Peptides

(2014) Julian D. Hegemann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibiting Epidermal Growth Factor Receptor at a Distance

(2014) Julie K.-L. Sinclair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein–Protein Interactions

(2014) Brooke Bullock Lao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stitched α-Helical Peptides via Bis Ring-Closing Metathesis

(2014) Gerard J. Hilinski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tailoring Peptidomimetics for Targeting Protein–Protein Interactions

(2014) Omar N. Akram et al.   MOLECULAR CANCER RESEARCH

Backbone modification of a polypeptide drug alters duration of action in vivo

(2014) Ross W Cheloha et al.   NATURE BIOTECHNOLOGY

Comprehensive analysis of loops at protein-protein interfaces for macrocycle design

(2014) Jason Gavenonis et al.   Nature Chemical Biology

Small-molecule modulation of Ras signaling

(2014) Jochen Spiegel et al.   Nature Chemical Biology

Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides

(2014) Shiyu Chen et al.   Nature Chemistry

Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies

(2014) Gregory H Bird et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Orthogonal functionalisation of α-helix mimetics

(2014) Anna Barnard et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Investigating peptide sequence variations for ‘double-click’ stapled p53 peptides

(2014) Yu Heng Lau et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Influence of Macrocyclization on Allosteric, Juxtamembrane-Derived, Stapled Peptide Inhibitors of the Epidermal Growth Factor Receptor (EGFR)

(2014) Julie K.-L. Sinclair et al.   ORGANIC LETTERS

In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics

(2014) B. B. Lao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many players in BCL-2 family affairs

(2014) Tudor Moldoveanu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Small molecule probes that perturb a protein–protein interface in antithrombin

(2014) Dongyue Xin et al.   Chemical Science

Functionalised staple linkages for modulating the cellular activity of stapled peptides

(2014) Yu Heng Lau et al.   Chemical Science

The structure of an MDM2–Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant

(2013) Burcu Anil et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Light-Regulated Stapled Peptides to Inhibit Protein-Protein Interactions Involved in Clathrin-Mediated Endocytosis

(2013) Laura Nevola et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct targeting of β-catenin: Inhibition of protein–protein interactions for the inactivation of Wnt signaling

(2013) Gernot Hahne et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Stapled peptide-based membrane fusion inhibitors of hepatitis C virus

(2013) Hong-Kui Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

α-Helix mimetics: Outwards and upwards

(2013) Madura K.P. Jayatunga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Membrane Permeability of Hydrocarbon-Cross-Linked Peptides

(2013) Tzu-Lin Sun et al.   BIOPHYSICAL JOURNAL

Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling

(2013) Hong-Kui Cui et al.   CELL RESEARCH

Cyclization of the Antimicrobial Peptide Gomesin with Native Chemical Ligation: Influences on Stability and Bioactivity

(2013) Lai Yue Chan et al.   CHEMBIOCHEM

Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins

(2013) Brian J. Smith et al.   CHEMBIOCHEM

A Newi,i + 3 Peptide Stapling System for α-Helix Stabilization

(2013) So Youn Shim et al.   Chemical Biology & Drug Design

Monosubstituted alkenyl amino acids for peptide “stapling”

(2013) David J. Yeo et al.   CHEMICAL COMMUNICATIONS

Solid-Phase Methodology for Synthesis ofO-Alkylated Aromatic Oligoamide Inhibitors of α-Helix-Mediated Protein-Protein Interactions

(2013) Natasha S. Murphy et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Modular Synthesis of Teraryl-Based α-Helix Mimetics, Part 1: Synthesis of Core Fragments with Two Electronically Differentiated Leaving Groups

(2013) Martin Peters et al.   CHEMISTRY-A EUROPEAN JOURNAL

Future directions for peptide therapeutics development

(2013) Allan A. Kaspar et al.   DRUG DISCOVERY TODAY

Aromatic Oligoamide Foldamers with a “Wet Edge” as Inhibitors of the α-Helix-Mediated p53-hDM2 Protein-Protein Interaction

(2013) Panchami Prabhakaran et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Recapitulating the α-helix: nonpeptidic, low-molecular-weight ligands for the modulation of helix-mediated protein–protein interactions

(2013) Maryanna Lanning et al.   Future Medicinal Chemistry

Identification of M. tuberculosis Thioredoxin Reductase Inhibitors Based on High-Throughput Docking Using Constraints

(2013) Oliver Koch et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin

(2013) Marta Pelay-Gimeno et al.   Marine Drugs

The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak

(2013) Xiaobo Cao et al.   Molecular Cancer

Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer

(2013) Woojin Kim et al.   Nature Chemical Biology

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Inhibition of Nutlin-Resistant HDM2 Mutants by Stapled Peptides

(2013) Siau Jia Wei et al.   PLoS One

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

(2013) Yong S. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling

(2013) S. Kushal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2 Agonism and Glucose-Dependent Insulin Secretion

(2013) Fabrizio Giordanetto et al.   ACS Medicinal Chemistry Letters

Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces

(2013) Dilraj Lama et al.   Scientific Reports

Comprehensive Peptidomimetic Libraries Targeting Protein–Protein Interactions

(2012) Landon R. Whitby et al.   ACCOUNTS OF CHEMICAL RESEARCH

Stapled Peptides with Improved Potency and Specificity That Activate p53

(2012) Christopher J. Brown et al.   ACS Chemical Biology

Improvement of enzymatic stability and intestinal permeability of deuterohemin-peptide conjugates by specific multi-site N-methylation

(2012) Qing-Guang Dong et al.   AMINO ACIDS

Hybrid Organic-Inorganic Inhibitors of a PDZ Interaction that Regulates the Endocytic Fate of CFTR

(2012) Rituparna Kundu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity

(2012) Oliver Demmer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions

(2012) Jayanta Chatterjee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

(2012) Kérya Long et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Modular Synthesis of Teraryl-Based α-Helix Mimetics, Part 2: Synthesis of 5-Pyridine Boronic Acid Pinacol Ester Building Blocks with Amino Acid Side Chains in 3-Position

(2012) Martin Peters et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Ultrahigh Affinity d-Peptide Antagonist Of MDM2

(2012) Changyou Zhan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclic Aza-peptide Integrin Ligand Synthesis and Biological Activity

(2012) Jochen Spiegel et al.   JOURNAL OF ORGANIC CHEMISTRY

Extending Foldamer Design beyond α-Helix Mimicry: α/β-Peptide Inhibitors of Vascular Endothelial Growth Factor Signaling

(2012) Holly S. Haase et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhancement of α-Helix Mimicry by an α/β-Peptide Foldamer via Incorporation of a Dense Ionic Side-Chain Array

(2012) Lisa M. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nucleation Effects in Peptide Foldamers

(2012) Anupam Patgiri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design Strategies for the Sequence-Based Mimicry of Side-Chain Display in Protein β-Sheets by α/β-Peptides

(2012) George A. Lengyel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-xL

(2012) Piotr Wysoczanski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

(2012) Avinash Muppidi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of α-Helical Calpain Probes by Mimicking a Natural Protein–Protein Interaction

(2012) Hyunil Jo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amphiphilic α-helix mimetics based on a benzoylurea scaffold

(2012) Sam Thompson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors

(2012) Jeremy L. Yap et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

2-O-Alkylated para-benzamide α-helix mimetics: the role of scaffold curvature

(2012) Valeria Azzarito et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Positional effects of click cyclization on β-hairpin structure, stability, and function

(2012) Jessica H. Park et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Spiroligomer α-Helix Mimic That Binds HDM2, Penetrates Human Cells and Stabilizes HDM2 in Cell Culture

(2012) Zachary Z. Brown et al.   PLoS One

Inhibition of oncogenic Wnt signaling through direct targeting of  -catenin

(2012) T. N. Grossmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Disruption of the BCL9/ -Catenin Complex Inhibits Oncogenic Wnt Signaling

(2012) K. Takada et al.   Science Translational Medicine

α/β-Peptide foldamers: state of the art

(2011) Ludwig K. A. Pilsl et al.   AMINO ACIDS

Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics

(2011) Kai Holland-Nell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

(2011) Carlos Mas-Moruno et al.   Anti-Cancer Agents in Medicinal Chemistry

Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition

(2011) Michael M. Madden et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Solid-phase synthesis of functionalized bis-peptides

(2011) Zachary Z. Brown et al.   BIOPOLYMERS

Novel structures of self-associating stapled peptides

(2011) Shibani Bhattacharya et al.   BIOPOLYMERS

A general synthesis of dirhodium metallopeptides as MDM2 ligands

(2011) Alexander N. Zaykov et al.   CHEMICAL COMMUNICATIONS

Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx

(2011) Avinash Muppidi et al.   CHEMICAL COMMUNICATIONS

Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

(2011) Andrew B. Mahon et al.   CHEMICAL COMMUNICATIONS

β-Hairpin stabilization through an interstrand triazole bridge

(2011) Veronica Celentano et al.   CHEMICAL COMMUNICATIONS

Peptidic foldamers: ramping up diversity

(2011) Tamás A. Martinek et al.   CHEMICAL SOCIETY REVIEWS

Context-Based Identification of Protein-Protein Interfaces and “Hot-Spot” Residues

(2011) Tim Geppert et al.   CHEMISTRY & BIOLOGY

Use of secondary structure element information in drug design: polypharmacology and conserved motifs in protein–ligand binding and protein–protein interfaces

(2011) Oliver Koch   Future Medicinal Chemistry

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

(2011) Steven A. Kawamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Validation of a β-Turn Mimetic Library Targeting Protein–Protein and Peptide–Receptor Interactions

(2011) Landon R. Whitby et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Assessing Helical Protein Interfaces for Inhibitor Design

(2011) Brooke N. Bullock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hairpin Folding Behavior of Mixed α/β-Peptides in Aqueous Solution

(2011) George A. Lengyel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the Stapled p53 Peptide Bound to Mdm2

(2011) Sohee Baek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Parallel β-Sheet Secondary Structure Is Stabilized and Terminated by Interstrand Disulfide Cross-Linking

(2011) Aaron M. Almeida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

(2011) Melissa D. Boersma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Structure of Stapled Peptides Binding to Estrogen Receptors

(2011) Chris Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An orthosteric inhibitor of the Ras-Sos interaction

(2011) Anupam Patgiri et al.   Nature Chemical Biology

Contemporary strategies for peptide macrocyclization

(2011) Christopher J. White et al.   Nature Chemistry

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

(2011) Young-Woo Kim et al.   Nature Protocols

G protein-coupled receptors: mutations and endocrine diseases

(2011) Gilbert Vassart et al.   Nature Reviews Endocrinology

mRNA Display Selection of an Optimized MDM2-Binding Peptide That Potently Inhibits MDM2-p53 Interaction

(2011) Hirokazu Shiheido et al.   PLoS One

Pyrrolinone-Based Peptidomimetics. “Let the Enzyme or Receptor be the Judge”

(2010) Amos B. Smith et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Left-Handed Solution to Peptide Inhibition of the p53-MDM2 Interaction

(2010) Min Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tryptophan residues: Scarce in proteins but strong stabilizers of β-hairpin peptides

(2010) Clara M. Santiveri et al.   BIOPOLYMERS

Peptoid origins

(2010) Ronald N. Zuckermann   BIOPOLYMERS

A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53

(2010) Federico Bernal et al.   CANCER CELL

High Specificity in Protein Recognition by Hydrogen-Bond-Surrogate α-Helices: Selective Inhibition of the p53/MDM2 Complex

(2010) Laura K. Henchey et al.   CHEMBIOCHEM

Update 1 of: Over One Hundred Peptide-Activated G Protein-Coupled Receptors Recognize Ligands with Turn Structure

(2010) Gloria Ruiz-Gómez et al.   CHEMICAL REVIEWS

Update 1 of: Beta-Strand Mimetics

(2010) Wendy A. Loughlin et al.   CHEMICAL REVIEWS

The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner

(2010) Aslamuzzaman Kazi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionary Origin of a Secondary Structure: π-Helices as Cryptic but Widespread Insertional Variations of α-Helices That Enhance Protein Functionality

(2010) Richard B. Cooley et al.   JOURNAL OF MOLECULAR BIOLOGY

Bridged β3-Peptide Inhibitors of p53-hDM2 Complexation: Correlation between Affinity and Cell Permeability

(2010) Arjel D. Bautista et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inducing α-Helices in Short Oligopeptides through Binding by an Artificial Hydrophobic Cavity

(2010) Christel Dolain et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Pyrrolopyrimidine-Based α-Helix Mimetics: Cell-Permeable Inhibitors of Protein−Protein Interactions

(2010) Ji Hoon Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

Solid-phase synthesis of short α-helices stabilized by the hydrogen bond surrogate approach

(2010) Anupam Patgiri et al.   Nature Protocols

N-alkylated oligoamide α-helical proteomimetics

(2010) Frederick Campbell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of Hexa- and Pentasubstituted Diketopiperazines from Sterically Hindered Amino Acids

(2010) Zachary Z. Brown et al.   ORGANIC LETTERS

Oligooxopiperazines as Nonpeptidic α-Helix Mimetics

(2010) Petra Tošovská et al.   ORGANIC LETTERS

Introduction of All-Hydrocarboni,i+3 Staples into α-Helices via Ring-Closing Olefin Metathesis

(2010) Young-Woo Kim et al.   ORGANIC LETTERS

D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms

(2010) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilizing capping motif for  -hairpins and sheets

(2010) B. L. Kier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

(2010) R. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural space of protein-protein interfaces is degenerate, close to complete, and highly connected

(2010) M. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

(2010) G. H. Bird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions?

(2010) Nir London et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

An automated method for consistent helix assignment using turn information

(2010) Oliver Koch et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Solid-Phase Synthesis of Tris-Benzamides as α-Helix Mimetics

(2010) Tae-Kyung Lee et al.   ACS Combinatorial Science

Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods

(2010) Christelle Reynès et al.   PLoS Computational Biology

Coreceptors and HIV-1 Pathogenesis

(2010) Paul R. Gorry et al.   Current HIV/AIDS Reports

Design of Highly Stabilized β-Hairpin Peptides through Cation−π Interactions of Lysine andN-Methyllysine with an Aromatic Pocket†

(2009) Alexander J. Riemen et al.   BIOCHEMISTRY

Role of Tryptophan−Tryptophan Interactions in Trpzip β-Hairpin Formation, Structure, and Stability

(2009) Ling Wu et al.   BIOCHEMISTRY

β-Peptides with improved affinity for hDM2 and hDMX

(2009) Elizabeth A. Harker et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of a β3-peptide HIV fusion inhibitor with improved potency in live cells

(2009) Arjel D. Bautista et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

A Highly Potent and Cellularly Active β-Peptidic Inhibitor of the p53/hDM2 Interaction

(2009) Martin Hintersteiner et al.   CHEMBIOCHEM

Cell-Permeable β-Peptide Inhibitors of p53/hDM2 Complexation

(2009) Elizabeth A. Harker et al.   CHEMBIOCHEM

Synthetic Inhibitors of Extended Helix-Protein Interactions Based on a Biphenyl 4,4′-Dicarboxamide Scaffold

(2009) Johanna M. Rodriguez et al.   CHEMBIOCHEM

Oligobenzamide proteomimetic inhibitors of the p53–hDM2 protein–protein interaction

(2009) Jeffrey P. Plante et al.   CHEMICAL COMMUNICATIONS

Structure and Function of Benzoylurea-Derived α-Helix Mimetics Targeting the Bcl-xL/Bak Binding Interface

(2009) Johanna M. Rodriguez et al.   ChemMedChem

Rationalizing the chemical space of protein–protein interaction inhibitors

(2009) Olivier Sperandio et al.   DRUG DISCOVERY TODAY

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

(2009) Jason Phan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secbase: Database Module To Retrieve Secondary Structure Elements with Ligand Binding Motifs

(2009) Oliver Koch et al.   Journal of Chemical Information and Modeling

In Silico Improvement of β3-Peptide Inhibitors of p53•hDM2 and p53•hDMX

(2009) Julien Michel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Macrocyclic Design Strategies for Small, Stable Parallel β-Sheet Scaffolds

(2009) Felix Freire et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alkyne-Linked 2,2-Disubstituted-indolin-3-one Oligomers as Extended β-Strand Mimetics

(2009) Pauline N. Wyrembak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Hypoxia Inducible Factor 1—Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix

(2009) Laura K. Henchey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

(2009) Christian Heinis et al.   Nature Chemical Biology

Synthesis of Stapled β3-Peptides through Ring-Closing Metathesis

(2009) Ylva E. Bergman et al.   ORGANIC LETTERS

Use of Disulfide “Staples” To Stabilize β-Sheet Quaternary Structure

(2009) Omid Khakshoor et al.   ORGANIC LETTERS

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

(2009) M. Pazgier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and biological mimicry of protein surface recognition by  / -peptide foldamers

(2009) W. S. Horne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Peptidic Peptidomimetics

(2008) Dieter Seebach et al.   ACCOUNTS OF CHEMICAL RESEARCH

Shape-Programmable Macromolecules

(2008) Christian E. Schafmeister et al.   ACCOUNTS OF CHEMICAL RESEARCH

Foldamers with Heterogeneous Backbones

(2008) W. Seth Horne et al.   ACCOUNTS OF CHEMICAL RESEARCH

How Useful Is Ferrocene as a Scaffold for the Design of β-Sheet Foldamers?

(2008) Somenath Chowdhury et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlling Curvature in a Family of Oligoamide α-Helix Mimetics

(2008) Ishu Saraogi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequence-Based Design of α/β-Peptide Foldamers That Mimic BH3 Domains

(2008) W. Seth Horne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of HIV-1 Fusion by Hydrogen-Bond-Surrogate-Based α Helices

(2008) Deyun Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photocontrollable Peptide-Based Switches Target the Anti-Apoptotic Protein Bcl-xL

(2008) Sabine Kneissl et al.   CHEMBIOCHEM

Designed Peptides with Homochiral and Heterochiral Diproline Templates as Conformational Constraints

(2008) Bhaswati Chatterjee et al.   CHEMISTRY-A EUROPEAN JOURNAL

Supramolecular Bidentate Ligands by Metal-Directed in situ Formation of Antiparallel β-Sheet Structures and Application in Asymmetric Catalysis

(2008) Andy C. Laungani et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of an Oxazole–Pyrrole–Piperazine Scaffold as an α-Helix Mimetic

(2008) Lionel Moisan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Cell-penetrating Helical Peptide as a Potential HIV-1 Inhibitor

(2008) Hongtao Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Proline Derived Spirobarbiturates as Highly Effective β-Turn Mimetics Incorporating Polar and Functionalizable Constraint Elements

(2008) Luelak Lomlim et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Conformational Analysis of a Cyclic Peptide Obtained viaitoi+4 Intramolecular Side-Chain to Side-Chain Azide−Alkyne 1,3-Dipolar Cycloaddition

(2008) Sonia Cantel et al.   JOURNAL OF ORGANIC CHEMISTRY

CanN-methylated amino acids serve as substitutes for prolines in conformational design of cyclic pentapeptides?

(2008) Burkhardt Laufer et al.   JOURNAL OF PEPTIDE SCIENCE

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE

Synthesis and Structure of 1,4-Dipiperazino Benzenes:  Chiral Terphenyl-type Peptide Helix Mimetics

(2008) Prantik Maity et al.   ORGANIC LETTERS

Functionalized Analogues of an Unnatural Amino Acid that Mimics a Tripeptide β-Strand

(2008) Tatyana V. Khasanova et al.   ORGANIC LETTERS

Synthesis and Biological Evaluation of a 5-6-5 Imidazole-Phenyl-Thiazole Based α-Helix Mimetic

(2008) Christopher G. Cummings et al.   ORGANIC LETTERS

Very short peptides with stable folds: Building on the interrelationship of Trp/Trp, Trp/cation, and Trp/backbone-amide interaction geometries

(2008) Lisa Eidenschink et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Prediction of turn types in protein structure by machine-learning classifiers

(2008) Michael Meissner et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Turns revisited: A uniform and comprehensive classification of normal, open, and reverse turn families minimizing unassigned random chain portions

(2008) Oliver Koch et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Context-Dependence of the Contribution of Disulfide Bonds to β-Hairpin Stability

(2007) Clara M. Santiveri et al.   CHEMISTRY-A EUROPEAN JOURNAL

Conformational Preference and Potential Templates ofN-Methylated Cyclic Pentaalanine Peptides

(2007) Jayanta Chatterjee et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Conformational Studies of Peptidomimetics Containing a New Bifunctional Diketopiperazine Scaffold Acting as a β-Hairpin Inducer

(2007) Ana Sofia M. Ressurreição et al.   JOURNAL OF ORGANIC CHEMISTRY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synthesis of functionalised aromatic oligamide rods

(2007) Jeffrey Plante et al.   ORGANIC & BIOMOLECULAR CHEMISTRY