期刊
CHEMICAL COMMUNICATIONS
卷 47, 期 39, 页码 10927-10929出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13169a
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资金
- John S. Dunn Gulf Coast Consortium for Chemical Genomics
- Robert A. Welch Foundation [C-1680]
- NSF [CHE-1055569]
- Division Of Chemistry [0947054] Funding Source: National Science Foundation
A synthesis of multifunctional dirhodium metallopeptide ligands for MDM2 is presented. An orthogonal protection scheme of palladium-catalyzed de-allylation on a metallopeptide substrate allows specific dirhodium incorporation in a complex peptide. Sequence effects on MDM2 binding are discussed.
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