期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 13, 期 1, 页码 258-264出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ob02066a
关键词
-
资金
- European Research Council [ERC-StG-240324]
- Engineering and Physical Sciences Research Council [1090344] Funding Source: researchfish
The exploitation of multivalent ligands for the inhibition of protein-protein interactions has not yet been explored as a supramolecular design strategy. This is despite the fact that protein-protein interactions typically occur within the context of multi-protein complexes and frequently exploit avidity effects or cooperative binding interactions to achieve high affinity interactions. In this paper we describe preliminary studies on the use of a multivalent N-alkylated aromatic oligoamide helix mimetic for inhibition of p53/hDM2 and establish that protein dimerisation is promoted, rather than enhanced binding resulting from a higher effective concentration of the ligand.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据