期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 21, 期 14, 页码 4034-4040出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2012.09.053
关键词
Aromatic oligoamide; Automated solid phase synthesis; Protein-protein interactions; Helix mimetic
资金
- Yorkshire Cancer Research [L348]
- European Research Council [240324]
- European Research Council (ERC) [240324] Funding Source: European Research Council (ERC)
Protein-protein interactions (PPIs) mediate cellular pathways and are implicated in numerous aberrant conditions. alpha-Helix mimetics-small molecules that reproduce the spatial projection of key residues from an alpha-helix involved in a PPI-are attractive generic templates for development of screening libraries, however library syntheses of alpha-helix mimetics with diverse functionality are less established. This manuscript describes the automated, microwave assisted solid phase synthesis based on one such scaffold; an N-allcylated oligobenzamide. (C) 2012 Elsevier Ltd. All rights reserved.
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