Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies

A critical question for HIV vaccine development: Which antibodies to induce?

(2014) S. Zolla-Pazner   SCIENCE

Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection

(2013) Peter Hraber et al.   AIDS

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Mechanism of HIV-1 Neutralization by Antibodies Targeting a Membrane-Proximal Region of gp41

(2013) J. Chen et al.   JOURNAL OF VIROLOGY

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

(2013) Hua-Xin Liao et al.   NATURE

Chimeric Rhinoviruses Displaying MPER Epitopes Elicit Anti-HIV Neutralizing Responses

(2013) Guohua Yi et al.   PLoS One

Increased Functional Stability and Homogeneity of Viral Envelope Spikes through Directed Evolution

(2013) Daniel P. Leaman et al.   PLoS Pathogens

Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10

(2013) Kathryn A. K. Finton et al.   PLoS Pathogens

Generation of HIV-1 potent and broad neutralizing antibodies by immunization with postfusion HR1/HR2 complex

(2012) Reham Dawood et al.   AIDS

Conformation-specific Display of 4E10 and 2F5 Epitopes on Self-assembling Protein Nanoparticles as a Potential HIV Vaccine

(2012) Newton Wahome et al.   Chemical Biology & Drug Design

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers

(2012) James L. LaBelle et al.   JOURNAL OF CLINICAL INVESTIGATION

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

(2012) Jinghe Huang et al.   NATURE

Targeted Disruption of the BCL9/ -Catenin Complex Inhibits Oncogenic Wnt Signaling

(2012) K. Takada et al.   Science Translational Medicine

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Present and Future of Peptide Vaccines for Cancer

(2011) Craig L. Slingluff   CANCER JOURNAL

Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope

(2011) Robyn L. Stanfield et al.   JOURNAL OF MOLECULAR BIOLOGY

On Resin Side-Chain Cyclization of Complex Peptides Using CuAAC

(2011) Sampat Ingale et al.   ORGANIC LETTERS

Heterologous Epitope-Scaffold Prime∶Boosting Immuno-Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant

(2011) Javier Guenaga et al.   PLoS One

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Interaction of Anti-HIV Type 1 Antibody 2F5 with Phospholipid Bilayers and Its Relevance for the Mechanism of Virus Neutralization

(2010) Rubén Maeso et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53

(2010) Federico Bernal et al.   CANCER CELL

Advances in the design and delivery of peptide subunit vaccines with a focus on Toll-like receptor agonists

(2010) Matthew Black et al.   Expert Review of Vaccines

Computational Protein Design Using Flexible Backbone Remodeling and Resurfacing: Case Studies in Structure-Based Antigen Design

(2010) Bruno E. Correia et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthesis and analysis of the membrane proximal external region epitopes of HIV-1

(2010) Sampat Ingale et al.   JOURNAL OF PEPTIDE SCIENCE

Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies

(2010) Gary Frey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Introduction of All-Hydrocarboni,i+3 Staples into α-Helices via Ring-Closing Olefin Metathesis

(2010) Young-Woo Kim et al.   ORGANIC LETTERS

Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

(2010) E. M. Scherer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elicitation of structure-specific antibodies by epitope scaffolds

(2010) G. Ofek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

(2010) G. H. Bird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope

(2010) Bruno E. Correia et al.   STRUCTURE

Crystal Structure of HIV-1 gp41 Including Both Fusion Peptide and Membrane Proximal External Regions

(2010) Victor Buzon et al.   PLoS Pathogens

Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes

(2009) Gary R Matyas et al.   AIDS

Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1

(2008) Gary R. Matyas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Both lipid environment and pH are critical for determining physiological solution structure of 3-D-conserved epitopes of the HIV-1 gp41-MPER peptide P1

(2008) Jérôme Coutant et al.   FASEB JOURNAL

Lipid modulation of membrane-bound epitope recognition and blocking by HIV-1 neutralizing antibodies

(2008) Nerea Huarte et al.   FEBS LETTERS

HIV-1 Broadly Neutralizing Antibody Extracts Its Epitope from a Kinked gp41 Ectodomain Region on the Viral Membrane

(2008) Zhen-Yu J. Sun et al.   IMMUNITY

Structural Details of HIV-1 Recognition by the Broadly Neutralizing Monoclonal Antibody 2F5: Epitope Conformation, Antigen-Recognition Loop Mobility, and Anion-Binding Site

(2008) Jean-Philippe Julien et al.   JOURNAL OF MOLECULAR BIOLOGY

The Membrane-Proximal External Region of the Human Immunodeficiency Virus Type 1 Envelope: Dominant Site of Antibody Neutralization and Target for Vaccine Design

(2008) M. Montero et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

(2008) G. Frey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV Vaccine Research: The Way Forward

(2008) A. S. Fauci et al.   SCIENCE

Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelope

(2007) Adam Penn-Nicholson et al.   VIROLOGY