Aromatic Oligoamide Foldamers with a Wet Edge as Inhibitors of the -Helix-Mediated p53-hDM2 Protein-Protein Interaction

This paper describes the design, synthesis and structural analysis of a 3-O-alkylated aromatic oligoamide that incorporates an additional hydrophilic 6-O-alkyl substituent in the central monomer. This oligomer exhibits low M inhibitory potency against the p53-hDM2 interaction compared with its unfunctionalised counterpart and significantly improved solubility.