Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes
出版年份 2015 全文链接
标题
Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes
作者
关键词
Actinomycete, Chemical mutagenesis, Genome mining, Heterologous expression, Regulatory genes, Ribosome engineering, RNA polymerase, Secondary metabolites, Synthetic biology, <em class=EmphasisTypeItalic >Streptomyces</em>, Transposon mutagenesis
出版物
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
Volume 43, Issue 2-3, Pages 343-370
出版商
Springer Nature
发表日期
2015-09-12
DOI
10.1007/s10295-015-1682-x
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces
- (2015) He Huang et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes
- (2015) Tilmann Weber et al. TRENDS IN BIOTECHNOLOGY
- Genome engineering and direct cloning of antibiotic gene clusters via phage ϕBT1 integrase-mediated site-specific recombination in Streptomyces
- (2015) Deyao Du et al. Scientific Reports
- Strain-Level Diversity of Secondary Metabolism in Streptomyces albus
- (2015) Ryan F. Seipke PLoS One
- Overproduction of Ristomycin A by Activation of a Silent Gene Cluster in Amycolatopsis japonicum MG417-CF17
- (2014) Marius Spohn et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- New Insights into Chloramphenicol Biosynthesis in Streptomyces venezuelae ATCC 10712
- (2014) Lorena T. Fernández-Martínez et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- WblAch, a Pivotal Activator of Natamycin Biosynthesis and Morphological Differentiation in Streptomyces chattanoogensis L10, Is Positively Regulated by AdpAch
- (2014) Pin Yu et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Novel and tightly regulated resorcinol and cumate-inducible expression systems for Streptomyces and other actinobacteria
- (2014) Liliya Horbal et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- PAS-LuxR transcriptional control of filipin biosynthesis in S. avermitilis
- (2014) Cláudia M. Vicente et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Unusual site-specific DNA integration into the highly active pseudo-attB of the Streptomyces albus J1074 genome
- (2014) Bohdan Bilyk et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Enhanced production of validamycin A in Streptomyces hygroscopicus 5008 by engineering validamycin biosynthetic gene cluster
- (2014) Tan-Che Zhou et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- The pathway-specific regulatory genes, tei15* and tei16*, are the master switches of teicoplanin production in Actinoplanes teichomyceticus
- (2014) Liliya Horbal et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Iterative marker excision system
- (2014) Maksym Myronovskyi et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems
- (2014) Chaitan Khosla et al. BIOCHEMISTRY
- A novel Streptomyces spp. integration vector derived from the S. venezuelae phage, SV1
- (2014) Bahgat Fayed et al. BMC BIOTECHNOLOGY
- Insights into naturally minimised Streptomyces albus J1074 genome
- (2014) Nestor Zaburannyi et al. BMC GENOMICS
- Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis
- (2014) Li Xu et al. BMC GENOMICS
- Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities
- (2014) Aleksandr Milshteyn et al. CHEMISTRY & BIOLOGY
- Recent advances in genome-based polyketide discovery
- (2014) Eric JN Helfrich et al. CURRENT OPINION IN BIOTECHNOLOGY
- Metagenomic small molecule discovery methods
- (2014) Zachary Charlop-Powers et al. CURRENT OPINION IN MICROBIOLOGY
- Spontaneous and induced mutations to rifampicin, streptomycin and spectinomycin resistances in actinomycetes: mutagenic mechanisms and applications for strain improvement
- (2014) Richard H Baltz JOURNAL OF ANTIBIOTICS
- Characterization of negative regulatory genes for the biosynthesis of rapamycin in Streptomyces rapamycinicus and its application for improved production
- (2014) Young Ji Yoo et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- SACE_3986, a TetR family transcriptional regulator, negatively controls erythromycin biosynthesis in Saccharopolyspora erythraea
- (2014) Panpan Wu et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Effect of Antibiotic Down-Regulatory Gene wblA Ortholog on Antifungal Polyene Production in Rare Actinomycetes Pseudonocardia autotrophica
- (2014) Hye-Jin Kim et al. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- New Applications for Phage Integrases
- (2014) Paul C.M. Fogg et al. JOURNAL OF MOLECULAR BIOLOGY
- Metabolomic Profiling and Genomic Study of a Marine Sponge-Associated Streptomyces sp.
- (2014) Christina Viegelmann et al. Marine Drugs
- Comparative genomics revealed key molecular targets to rapidly convert a reference rifamycin-producing bacterial strain into an overproducer by genetic engineering
- (2014) Clelia Peano et al. METABOLIC ENGINEERING
- Rational selection and engineering of exogenous principal sigma factor (σHrdB) to increase teicoplanin production in an industrial strain of Actinoplanes teichomyceticus
- (2014) Haiyong Wang et al. Microbial Cell Factories
- Structure of a modular polyketide synthase
- (2014) Somnath Dutta et al. NATURE
- Structural rearrangements of a polyketide synthase module during its catalytic cycle
- (2014) Jonathan R. Whicher et al. NATURE
- Functional optimization of gene clusters by combinatorial design and assembly
- (2014) Michael J Smanski et al. NATURE BIOTECHNOLOGY
- A Single Sfp-Type Phosphopantetheinyl Transferase Plays a Major Role in the Biosynthesis of PKS and NRPS Derived Metabolites in Streptomyces ambofaciens ATCC23877
- (2014) Robert Bunet et al. PLoS One
- Genomics of Sponge-Associated Streptomyces spp. Closely Related to Streptomyces albus J1074: Insights into Marine Adaptation and Secondary Metabolite Biosynthesis Potential
- (2014) Elena Ian et al. PLoS One
- Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A
- (2014) Kazuya Yamanaka et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Generation and study of the strains of streptomycetes-heterologous hosts for the production of moenomycin
- (2014) M. Lopatniuk et al. RUSSIAN JOURNAL OF GENETICS
- Use of the Meganuclease I-SceI of Saccharomyces cerevisiae to select for gene deletions in actinomycetes
- (2014) Lorena T. Fernández-Martínez et al. Scientific Reports
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- (2014) Marnix H. Medema et al. PLoS Computational Biology
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- (2014) Ryan F. Seipke et al. PeerJ
- Activation and identification of five clusters for secondary metabolites inStreptomyces albus J1074
- (2014) Carlos Olano et al. Microbial Biotechnology
- Improvement of Natamycin Production by Engineering of Phosphopantetheinyl Transferases in Streptomyces chattanoogensis L10
- (2013) Hui Jiang et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
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- (2013) Mervyn J. Bibb BIOCHEMICAL SOCIETY TRANSACTIONS
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- (2013) Y. Tanaka et al. JOURNAL OF BACTERIOLOGY
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- (2013) Huiling Wu et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
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- (2013) Gregory L. Challis JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
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- (2013) Ryan E. Cobb et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
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- (2013) Christopher N. Boddy JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
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- Actinomycetes biosynthetic potential: how to bridge in silico and in vivo?
- (2013) Yuriy Rebets et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
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- (2013) Haruo Ikeda et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Triggers and cues that activate antibiotic production by actinomycetes
- (2013) Hua Zhu et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?
- (2013) Brian O. Bachmann et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements
- (2013) Kozo Ochi et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- MbtH homology codes to identify gifted microbes for genome mining
- (2013) Richard H. Baltz JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Genome mining of Streptomyces ambofaciens
- (2013) Bertrand Aigle et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways
- (2013) Juan Pablo Gomez-Escribano et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes
- (2013) Theresa Siegl et al. METABOLIC ENGINEERING
- Disruption of rimP-SC, encoding a ribosome assembly cofactor, markedly enhances the production of several antibiotics in Streptomyces coelicolor
- (2013) Yuanyuan Pan et al. Microbial Cell Factories
- SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea
- (2013) Benjamin Kirm et al. Microbial Cell Factories
- Molecular Regulation of Antibiotic Biosynthesis in Streptomyces
- (2013) G. Liu et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- RNA-guided editing of bacterial genomes using CRISPR-Cas systems
- (2013) Wenyan Jiang et al. NATURE BIOTECHNOLOGY
- Cas9 as a versatile tool for engineering biology
- (2013) Prashant Mali et al. NATURE METHODS
- Naphthyridinomycin Biosynthesis Revealing the Use of Leader Peptide to Guide Nonribosomal Peptide Assembly
- (2013) Jin-Yue Pu et al. ORGANIC LETTERS
- An Efficient Procedure for Marker-Free Mutagenesis of S. coelicolor by Site-Specific Recombination for Secondary Metabolite Overproduction
- (2013) Bo Zhang et al. PLoS One
- Phage P1-Derived Artificial Chromosomes Facilitate Heterologous Expression of the FK506 Gene Cluster
- (2013) Adam C. Jones et al. PLoS One
- Identification of Mur34 as the Novel Negative Regulator Responsible for the Biosynthesis of Muraymycin in Streptomyces sp. NRRL30471
- (2013) Dongmei Xu et al. PLoS One
- Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism
- (2013) D. K. Derewacz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites
- (2013) Mamoru Komatsu et al. ACS Synthetic Biology
- Refactoring the Silent Spectinabilin Gene Cluster Using a Plug-and-Play Scaffold
- (2013) Zengyi Shao et al. ACS Synthetic Biology
- An Insight into the “-Omics” Based Engineering of Streptomycetes for Secondary Metabolite Overproduction
- (2013) Amit Kumar Chaudhary et al. Biomed Research International
- Site-Specific Recombination Strategies for Engineering Actinomycete Genomes
- (2012) Simone Herrmann et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters
- (2012) Kozo Ochi et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- In vivo random mutagenesis of streptomycetes using mariner-based transposon Himar1
- (2012) Bohdan Bilyk et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Sequential deletion of all the polyketide synthase and nonribosomal peptide synthetase biosynthetic gene clusters and a 900-kb subtelomeric sequence of the linear chromosome of Streptomyces coelicolor
- (2012) Min Zhou et al. FEMS MICROBIOLOGY LETTERS
- Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)
- (2012) C. Barreiro et al. JOURNAL OF BACTERIOLOGY
- Artificial Chromosomes to Explore and to Exploit Biosynthetic Capabilities of Actinomycetes
- (2012) Rosa Alduina et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Tetarimycin A, an MRSA-Active Antibiotic Identified through Induced Expression of Environmental DNA Gene Clusters
- (2012) Dimitris Kallifidas et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain
- (2012) Clelia Peano et al. Microbial Cell Factories
- Expression of the chaplin and rodlin hydrophobic sheath proteins in Streptomyces venezuelae is controlled by σBldN and a cognate anti-sigma factor, RsbN
- (2012) Maureen J. Bibb et al. MOLECULAR MICROBIOLOGY
- Diverse control of metabolism and other cellular processes in Streptomyces coelicolor by the PhoP transcription factor: genome-wide identification of in vivo targets
- (2012) Nicholas E. E. Allenby et al. NUCLEIC ACIDS RESEARCH
- Biosynthetic Pathway for High Structural Diversity of a Common Dilactone Core in Antimycin Production
- (2012) Yan Yan et al. ORGANIC LETTERS
- Hierarchical Control on Polyene Macrolide Biosynthesis: PimR Modulates Pimaricin Production via the PAS-LuxR Transcriptional Activator PimM
- (2012) Javier Santos-Aberturas et al. PLoS One
- Refactoring the nitrogen fixation gene cluster from Klebsiella oxytoca
- (2012) K. Temme et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Combinatorial Biosynthesis of Cyclic Lipopeptide Antibiotics: A Model for Synthetic Biology To Accelerate the Evolution of Secondary Metabolite Biosynthetic Pathways
- (2012) Richard H. Baltz ACS Synthetic Biology
- Discovery and Engineered Overproduction of Antimicrobial Nucleoside Antibiotic A201A from the Deep-Sea Marine Actinomycete Marinactinospora thermotolerans SCSIO 00652
- (2011) Qinghua Zhu et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The construction of a library of synthetic promoters revealed some specific features of strong Streptomyces promoters
- (2011) Nicolas Seghezzi et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes
- (2011) Steven T Pullan et al. BMC GENOMICS
- Whole Genome Sequence of the Rifamycin B-Producing Strain Amycolatopsis mediterranei S699
- (2011) M. Verma et al. JOURNAL OF BACTERIOLOGY
- ZouA, a Putative Relaxase, Is Essential for DNA Amplification in Streptomyces kanamyceticus
- (2011) T. Murakami et al. JOURNAL OF BACTERIOLOGY
- Genome Sequence of the Spinosyns-Producing Bacterium Saccharopolyspora spinosa NRRL 18395
- (2011) Y. Pan et al. JOURNAL OF BACTERIOLOGY
- Draft Genome Sequence of Streptomyces Strain S4, a Symbiont of the Leaf-Cutting Ant Acromyrmex octospinosus
- (2011) R. F. Seipke et al. JOURNAL OF BACTERIOLOGY
- Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery
- (2011) Richard H. Baltz JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Strain improvement in actinomycetes in the postgenomic era
- (2011) Richard H. Baltz JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Streptomyces temperate bacteriophage integration systems for stable genetic engineering of actinomycetes (and other organisms)
- (2011) Richard H. Baltz JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Efficient transposition of IS204-derived plasmids in Streptomyces coelicolor
- (2011) Xincheng Zhang et al. JOURNAL OF MICROBIOLOGICAL METHODS
- Comparative Analysis of the Biosynthetic Gene Clusters and Pathways for Three Structurally Related Antitumor Antibiotics: Bleomycin, Tallysomycin, and Zorbamycin
- (2011) Ute Galm et al. JOURNAL OF NATURAL PRODUCTS
- Imaging Mass Spectrometry and Genome Mining via Short Sequence Tagging Identified the Anti-Infective Agent Arylomycin inStreptomyces roseosporus
- (2011) Wei-Ting Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Functional conservation of PAS–LuxR transcriptional regulators in polyene macrolide biosynthesis
- (2011) Javier Santos-Aberturas et al. METABOLIC ENGINEERING
- The regulation of the secondary metabolism of Streptomyces: new links and experimental advances
- (2011) Gilles P. van Wezel et al. NATURAL PRODUCT REPORTS
- A Single Streptomyces Symbiont Makes Multiple Antifungals to Support the Fungus Farming Ant Acromyrmex octospinosus
- (2011) Ryan F. Seipke et al. PLoS One
- A system for the targeted amplification of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor
- (2011) T. Murakami et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
- (2011) L. Laureti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Development of a Genetic System for Combinatorial Biosynthesis of Lipopeptides in Streptomyces fradiae and Heterologous Expression of the A54145 Biosynthesis Gene Cluster
- (2010) D. C. Alexander et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation
- (2010) Yihua Chen et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT–PCR
- (2010) Dong Yang et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Use of an inducible promoter for antibiotic production in a heterologous host
- (2010) Volker Dangel et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- I-SceI endonuclease: a new tool for DNA repair studies and genetic manipulations in streptomycetes
- (2010) Theresa Siegl et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Identification of the Tirandamycin Biosynthetic Gene Cluster fromStreptomycessp. 307-9
- (2010) Jacob C. Carlson et al. CHEMBIOCHEM
- Biosynthesis of rapamycin and its regulation: past achievements and recent progress
- (2010) Sung Ryeol Park et al. JOURNAL OF ANTIBIOTICS
- Genomics and the ancient origins of the daptomycin biosynthetic gene cluster
- (2010) Richard H Baltz JOURNAL OF ANTIBIOTICS
- Characterization and Manipulation of the Pathway-Specific Late Regulator AlpW Reveals Streptomyces ambofaciens as a New Producer of Kinamycins
- (2010) R. Bunet et al. JOURNAL OF BACTERIOLOGY
- Regulation of the Biosynthesis of the Macrolide Antibiotic Spiramycin in Streptomyces ambofaciens
- (2010) F. Karray et al. JOURNAL OF BACTERIOLOGY
- The Actinomycin Biosynthetic Gene Cluster of Streptomyces chrysomallus: a Genetic Hall of Mirrors for Synthesis of a Molecule with Mirror Symmetry
- (2010) U. Keller et al. JOURNAL OF BACTERIOLOGY
- Molecular Control of Polyene Macrolide Biosynthesis
- (2010) Javier Santos-Aberturas et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters
- (2010) Richard H. Baltz JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Genetic factors that influence moenomycin production in streptomycetes
- (2010) Roman Makitrynskyy et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains
- (2010) Lili Li et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Tailoring Enzyme-Rich Environmental DNA Clones: A Source of Enzymes for Generating Libraries of Unnatural Natural Products
- (2010) Jacob J. Banik et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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- (2010) Christopher T. Walsh et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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- (2010) SangJoon Mo et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis
- (2010) Y. Zhuo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
- (2010) M. Komatsu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA Cleavage is Independent of Synapsis during Streptomyces Phage φBT1 Integrase-Mediated Site-Specific Recombination
- (2010) Lin Zhang et al. Journal of Molecular Cell Biology
- Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus
- (2010) Marnix H. Medema et al. Microbial Biotechnology
- Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters
- (2010) Juan Pablo Gomez-Escribano et al. Microbial Biotechnology
- Characterization of the ‘pristinamycin supercluster’ of Streptomyces pristinaespiralis
- (2010) Yvonne Mast et al. Microbial Biotechnology
- Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes
- (2009) Y. Tanaka et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Characterization of rrdA, a TetR Family Protein Gene Involved in the Regulation of Secondary Metabolism in Streptomyces coelicolor
- (2009) X. Ou et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- In vivo Tn5-based transposon mutagenesis of Streptomycetes
- (2009) Lutz Petzke et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Identification of a novel Streptomyces chattanoogensis L10 and enhancing its natamycin production by overexpressing positive regulator ScnRII
- (2009) Yi-Ling Du et al. JOURNAL OF MICROBIOLOGY
- High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain
- (2009) Chaoxuan Li et al. METABOLIC ENGINEERING
- Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production
- (2009) Elisabetta Carata et al. Microbial Cell Factories
- Automated design of synthetic ribosome binding sites to control protein expression
- (2009) Howard M Salis et al. NATURE BIOTECHNOLOGY
- Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12
- (2009) Takeshi Hosaka et al. NATURE BIOTECHNOLOGY
- Phosphate control over nitrogen metabolism in Streptomyces coelicolor: direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP
- (2009) Antonio Rodríguez-García et al. NUCLEIC ACIDS RESEARCH
- Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations
- (2008) G. Wang et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Engineered production of iso-migrastatin in heterologous Streptomyces hosts
- (2008) Zhiyang Feng et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Renaissance in antibacterial discovery from actinomycetes
- (2008) R BALTZ CURRENT OPINION IN PHARMACOLOGY
- Role of Phosphopantetheinyl Transferase Genes in Antibiotic Production by Streptomyces coelicolor
- (2008) Y.-W. Lu et al. JOURNAL OF BACTERIOLOGY
- Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering
- (2008) Carlos Olano et al. METABOLIC ENGINEERING
- A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea
- (2008) C. Chng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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