Actinomycetes biosynthetic potential: how to bridge in silico and in vivo?

An Engineered Strong Promoter for Streptomycetes

(2013) W. Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improvement of gougerotin and nikkomycin production by engineering their biosynthetic gene clusters

(2013) Deyao Du et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Novel Tryptophan Metabolism by a Potential Gene Cluster That Is Widely Distributed among Actinomycetes

(2013) Taro Ozaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements

(2013) Kozo Ochi et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways

(2013) Juan Pablo Gomez-Escribano et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Synthetic riboswitches for the conditional control of gene expression in Streptomyces coelicolor

(2013) M. M. Rudolph et al.   MICROBIOLOGY-SGM

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Transcriptomic Analysis of Streptomyces coelicolor Differentiation in Solid Sporulating Cultures: First Compartmentalized and Second Multinucleated Mycelia Have Different and Distinctive Transcriptomes

(2013) Paula Yagüe et al.   PLoS One

Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2)

(2013) Gabriel C. Uguru et al.   PLoS One

Alternative Sigma Factor Over-Expression Enables Heterologous Expression of a Type II Polyketide Biosynthetic Pathway in Escherichia coli

(2013) David Cole Stevens et al.   PLoS One

Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites

(2013) Mamoru Komatsu et al.   ACS Synthetic Biology

Site-Specific Recombination Strategies for Engineering Actinomycete Genomes

(2012) Simone Herrmann et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genome-based cryptic gene discovery and functional identification of NRPS siderophore peptide in Streptomyces peucetius

(2012) Hae-Min Park et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Genome-based bioprospecting of microbes for new therapeutics

(2012) Sergey B Zotchev et al.   CURRENT OPINION IN BIOTECHNOLOGY

Sequential deletion of all the polyketide synthase and nonribosomal peptide synthetase biosynthetic gene clusters and a 900-kb subtelomeric sequence of the linear chromosome of Streptomyces coelicolor

(2012) Min Zhou et al.   FEMS MICROBIOLOGY LETTERS

Improvement of A21978C production in Streptomyces roseosporus by reporter-guided rpsL mutation selection

(2012) L. Wang et al.   JOURNAL OF APPLIED MICROBIOLOGY

RNA-Seq and RNA Immunoprecipitation Analyses of the Transcriptome of Streptomyces coelicolor Identify Substrates for RNase III

(2012) M. L. Gatewood et al.   JOURNAL OF BACTERIOLOGY

Artificial Chromosomes to Explore and to Exploit Biosynthetic Capabilities of Actinomycetes

(2012) Rosa Alduina et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Predictive design of mRNA translation initiation region to control prokaryotic translation efficiency

(2012) Sang Woo Seo et al.   METABOLIC ENGINEERING

A highly specialized flavin mononucleotide riboswitch responds differently to similar ligands and confers roseoflavin resistance to Streptomyces davawensis

(2012) Danielle Biscaro Pedrolli et al.   NUCLEIC ACIDS RESEARCH

Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145

(2012) Juan Pablo Gomez-Escribano et al.   Chemical Science

Activation of a silent phenazine biosynthetic gene cluster reveals a novel natural product and a new resistance mechanism against phenazines

(2012) Orwah Saleh et al.   MedChemComm

β-Glucuronidase as a Sensitive and Versatile Reporter in Actinomycetes

(2011) Maksym Myronovskyi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The construction of a library of synthetic promoters revealed some specific features of strong Streptomyces promoters

(2011) Nicolas Seghezzi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Development of a gene cloning system in a fast-growing and moderately thermophilic Streptomyces species and heterologous expression of Streptomyces antibiotic biosynthetic gene clusters

(2011) Weihua Chen et al.   BMC MICROBIOLOGY

Imaging Mass Spectrometry and Genome Mining via Short Sequence Tagging Identified the Anti-Infective Agent Arylomycin inStreptomyces roseosporus

(2011) Wei-Ting Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler

(2011) Zengyi Shao et al.   Molecular BioSystems

Determinants of translation efficiency and accuracy

(2011) H. Gingold et al.   Molecular Systems Biology

A mass spectrometry–guided genome mining approach for natural product peptidogenomics

(2011) Roland D Kersten et al.   Nature Chemical Biology

Termination and antitermination: RNA polymerase runs a stop sign

(2011) Thomas J. Santangelo et al.   NATURE REVIEWS MICROBIOLOGY

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ARNold: A web tool for the prediction of Rho-independent transcription terminators

(2011) Magali Naville et al.   RNA Biology

Deep sequencing-based identification of small non-coding RNAs inStreptomyces coelicolor

(2011) Michael-Paul Vockenhuber et al.   RNA Biology

Use of an inducible promoter for antibiotic production in a heterologous host

(2010) Volker Dangel et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

RBSDesigner: software for designing synthetic ribosome binding sites that yields a desired level of protein expression

(2010) D. Na et al.   BIOINFORMATICS

Rare earth elements activate the secondary metabolite–biosynthetic gene clusters in Streptomyces coelicolor A3(2)

(2010) Yukinori Tanaka et al.   JOURNAL OF ANTIBIOTICS

“Pseudo” γ-Butyrolactone Receptors Respond to Antibiotic Signals to Coordinate Antibiotic Biosynthesis

(2010) Gangming Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

(2010) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Robust reporter system based on chalcone synthase rppA gene from Saccharopolyspora erythraea

(2010) V. Magdevska et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Streptomyces coelicolor A3(2) Produces a New Yellow Pigment Associated with the Polyketide Synthase Cpk

(2010) Krzysztof Pawlik et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)

(2010) M. Gottelt et al.   MICROBIOLOGY-SGM

WebGeSTer DB—a transcription terminator database

(2010) Anirban Mitra et al.   NUCLEIC ACIDS RESEARCH

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

(2010) M. Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Properties of lanK-based regulatory circuit involved in landomycin biosynthesis in Streptomyces cyanogenus S136

(2010) B. Ostash et al.   RUSSIAN JOURNAL OF GENETICS

Riboswitches and the RNA World

(2010) R. R. Breaker   Cold Spring Harbor Perspectives in Biology

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

(2010) Juan Pablo Gomez-Escribano et al.   Microbial Biotechnology

Adaptation of the Highly Productive T7 Expression System to Streptomyces lividans

(2009) F.-X. Lussier et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

An overview of RNAs with regulatory functions in gram-positive bacteria

(2009) Pascale Romby et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcriptomics analyses reveal global roles of the regulator AveI inStreptomyces avermitilis

(2009) Lei Chen et al.   FEMS MICROBIOLOGY LETTERS

Imaging of Streptomyces coelicolor A3(2) with Reduced Autofluorescence Reveals a Novel Stage of FtsZ Localization

(2009) Joost Willemse et al.   PLoS One

Towards Prediction of Metabolic Products of Polyketide Synthases: An In Silico Analysis

(2009) Gitanjali Yadav et al.   PLoS Computational Biology

Functional expression of the Cre recombinase in actinomycetes

(2008) Marta Fedoryshyn et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The use of the rare UUA codon to define “Expression Space” for genes involved in secondary metabolism, development and environmental adaptation in Streptomyces

(2008) Keith F. Chater et al.   JOURNAL OF MICROBIOLOGY

Uncovering Genes with Divergent mRNA-Protein Dynamics in Streptomyces coelicolor

(2008) Karthik P. Jayapal et al.   PLoS One

pTONA5: A hyperexpression vector in streptomycetes

(2008) Tadashi Hatanaka et al.   PROTEIN EXPRESSION AND PURIFICATION