New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

Production of xylanase by an alkaline-tolerant marine-derived Streptomyces viridochromogenes strain and improvement by ribosome engineering

(2012) Zhuo Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Role of altered rpoB alleles in Bacillus subtilis sporulation and spore resistance to heat, hydrogen peroxide, formaldehyde, and glutaraldehyde

(2012) Ralf Moeller et al.   ARCHIVES OF MICROBIOLOGY

A Magic Bullet for Antibiotic Discovery

(2012) Kozo Ochi et al.   CHEMISTRY & BIOLOGY

Chemical Perturbation of Secondary Metabolism Demonstrates Important Links to Primary Metabolism

(2012) Arryn Craney et al.   CHEMISTRY & BIOLOGY

Genome Shuffling of Clostridium acetobutylicum CICC 8012 for Improved Production of Acetone–Butanol–Ethanol (ABE)

(2012) Xiaofeng Gao et al.   CURRENT MICROBIOLOGY

Development of the ability to produce secondary metabolites in Streptomyces through the acquisition of erythromycin resistance

(2012) Yu Imai et al.   JOURNAL OF ANTIBIOTICS

Improvement of A21978C production in Streptomyces roseosporus by reporter-guided rpsL mutation selection

(2012) L. Wang et al.   JOURNAL OF APPLIED MICROBIOLOGY

Undecaprenyl Pyrophosphate Involvement in Susceptibility of Bacillus subtilis to Rare Earth Elements

(2012) T. Inaoka et al.   JOURNAL OF BACTERIOLOGY

Significantly Enhanced Production of Acarbose in Fed-Batch Fermentation with the Addition of S-Adenosylmethionine

(2012) Li-Hui Sun   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Activation of the Dormant Secondary Metabolite Production by Introducing Gentamicin-Resistance in a Marine-Derived Penicillium purpurogenum G59

(2012) Yun-Jing Chai et al.   Marine Drugs

Heterologous expression of a plant RelA-SpoT homologue results in increased stress tolerance in Saccharomyces cerevisiae by accumulation of the bacterial alarmone ppGpp

(2012) K. Ochi et al.   MICROBIOLOGY-SGM

Genetic and Proteomic Characterization of rpoB Mutations and Their Effect on Nematicidal Activity in Photorhabdus luminescens LN2

(2012) Xuehong Qiu et al.   PLoS One

Scandium Stimulates the Production of Amylase and Bacilysin in Bacillus subtilis

(2011) Takashi Inaoka et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Metabolic Engineering of Nocardia sp. CS682 for Enhanced Production of Nargenicin A1

(2011) Sushila Maharjan et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Strain improvement in actinomycetes in the postgenomic era

(2011) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Enhancement of pradimicin production in Actinomadura hibisca P157-2 by metabolic engineering

(2011) Sarita Paudel et al.   MICROBIOLOGICAL RESEARCH

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

(2011) Gilles P. van Wezel et al.   NATURAL PRODUCT REPORTS

Signalling by the global regulatory molecule ppGpp in bacteria and chloroplasts of land plants

(2011) Y. Tozawa et al.   PLANT BIOLOGY

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global effect of an RNA polymerase β-subunit mutation on gene expression in the radiation-resistant bacterium Deinococcus radiodurans

(2011) XiaoTing Hua et al.   Science China-Life Sciences

Development of a Genetic System for Combinatorial Biosynthesis of Lipopeptides in Streptomyces fradiae and Heterologous Expression of the A54145 Biosynthesis Gene Cluster

(2010) D. C. Alexander et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Mycolic Acid-Containing Bacteria Induce Natural-Product Biosynthesis inStreptomycesSpecies

(2010) Hiroyasu Onaka et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

S-Adenosylmethionine (SAM) and antibiotic biosynthesis: effect of external addition of SAM and of overexpression of SAM biosynthesis genes on novobiocin production in Streptomyces

(2010) Xin Qing Zhao et al.   ARCHIVES OF MICROBIOLOGY

Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms

(2010) Yi-Ming Chiang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Rare earth elements activate the secondary metabolite–biosynthetic gene clusters in Streptomyces coelicolor A3(2)

(2010) Yukinori Tanaka et al.   JOURNAL OF ANTIBIOTICS

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

(2010) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains

(2010) Lili Li et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

RNA polymerase mutations that facilitate replication progression in the rep uvrD recF mutant lacking two accessory replicative helicases

(2010) Zeynep Baharoglu et al.   MOLECULAR MICROBIOLOGY

Antibiotic resistant mutants of Escherichia coli K12 show increases in heterologous gene expression

(2010) Adnan Ahmetagic et al.   PLASMID

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

(2010) M. Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

(2010) Juan Pablo Gomez-Escribano et al.   Microbial Biotechnology

Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes

(2009) Y. Tanaka et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Activation of secondary metabolite–biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus

(2009) Yukinori Tanaka et al.   JOURNAL OF ANTIBIOTICS

Production improvement of antifungal, antitrypanosomal nucleoside sinefungin by rpoB mutation and optimization of resting cell system of Streptomyces incarnatus NRRL 8089

(2009) Koji Fukuda et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production

(2009) Elisabetta Carata et al.   Microbial Cell Factories

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

(2009) Takeshi Hosaka et al.   NATURE BIOTECHNOLOGY

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans

(2009) V. Schroeckh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Insertion Mutation in Streptomyces coelicolor Ribosomal S12 Protein Results in Paromomycin Resistance and Antibiotic Overproduction

(2008) G. Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inactivation of KsgA, a 16S rRNA Methyltransferase, Causes Vigorous Emergence of Mutants with High-Level Kasugamycin Resistance

(2008) K. Ochi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations

(2008) G. Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Heterologous expression of metK1-sp and afsR-sp in Streptomyces venezuelae for the production of pikromycin

(2008) Sushila Maharjan et al.   BIOTECHNOLOGY LETTERS

Combinatorial engineering of microbes for optimizing cellular phenotype

(2008) Christine Nicole S Santos et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

(2008) Sébastien Rigali et al.   EMBO REPORTS

Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350

(2008) Y. Ohnishi et al.   JOURNAL OF BACTERIOLOGY

Activation of Dormant Bacterial Genes byNonomuraeasp. Strain ATCC 39727 Mutant-Type RNA Polymerase

(2008) Adelfia Talà et al.   JOURNAL OF BACTERIOLOGY

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

(2008) Carlos Olano et al.   METABOLIC ENGINEERING

Epigenetic remodeling of the fungal secondary metabolome

(2008) Russell B. Williams et al.   ORGANIC & BIOMOLECULAR CHEMISTRY