The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces

(2011) J. Willemse et al.   GENES & DEVELOPMENT

Repression of Antibiotic Production and Sporulation in Streptomyces coelicolor by Overexpression of a TetR Family Transcriptional Regulator

(2010) D. Xu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

S-Adenosylmethionine (SAM) and antibiotic biosynthesis: effect of external addition of SAM and of overexpression of SAM biosynthesis genes on novobiocin production in Streptomyces

(2010) Xin Qing Zhao et al.   ARCHIVES OF MICROBIOLOGY

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor

(2010) Mohammad T Alam et al.   BMC GENOMICS

The dynamic architecture of the metabolic switch in Streptomyces coelicolor

(2010) Kay Nieselt et al.   BMC GENOMICS

Pushing and Pulling in Prokaryotic DNA Segregation

(2010) Kenn Gerdes et al.   CELL

Morphogenetic Signaling Molecules of the Streptomycetes

(2010) Joanne M. Willey et al.   CHEMICAL REVIEWS

Production of microbial secondary metabolites: Regulation by the carbon source

(2010) Beatriz Ruiz et al.   CRITICAL REVIEWS IN MICROBIOLOGY

How to discover new antibiotics: harvesting the parvome

(2010) Julian Davies   CURRENT OPINION IN CHEMICAL BIOLOGY

Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces

(2010) Juan-Francisco Martín et al.   CURRENT OPINION IN MICROBIOLOGY

Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1

(2010) Nancy L McKenzie et al.   JOURNAL OF ANTIBIOTICS

Carbon source regulation of antibiotic production

(2010) Sergio Sánchez et al.   JOURNAL OF ANTIBIOTICS

Regulation of the Biosynthesis of the Macrolide Antibiotic Spiramycin in Streptomyces ambofaciens

(2010) F. Karray et al.   JOURNAL OF BACTERIOLOGY

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

(2010) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Quantitative Proteome Analysis ofStreptomyces coelicolorNonsporulating Liquid Cultures Demonstrates a Complex Differentiation Process Comparable to That Occurring in Sporulating Solid Cultures

(2010) Angel Manteca et al.   JOURNAL OF PROTEOME RESEARCH

Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)

(2010) M. Gottelt et al.   MICROBIOLOGY-SGM

Quantitative Proteomics Analysis ofStreptomyces coelicolorDevelopment Demonstrates That Onset of Secondary Metabolism Coincides with Hypha Differentiation

(2010) Angel Manteca et al.   MOLECULAR & CELLULAR PROTEOMICS

The Streptomyces coelicolor GlnR regulon: identification of new GlnR targets and evidence for a central role of GlnR in nitrogen metabolism in actinomycetes

(2010) Yvonne Tiffert et al.   MOLECULAR MICROBIOLOGY

The permease genenagE2is the key toN-acetylglucosamine sensing and utilization inStreptomyces coelicolorand is subject to multi-level control

(2010) Harald Nothaft et al.   MOLECULAR MICROBIOLOGY

The twin arginine protein transport pathway exports multiple virulence proteins in the plant pathogen Streptomyces scabies

(2010) Madhumita V. Joshi et al.   MOLECULAR MICROBIOLOGY

Regulation of morphological differentiation inS. coelicolorby RNase III (AbsB) cleavage of mRNA encoding the AdpA transcription factor

(2010) Weijing Xu et al.   MOLECULAR MICROBIOLOGY

Genes essential for morphological development and antibiotic production in Streptomyces coelicolor are targets of BldD during vegetative growth

(2010) Chris D. Den Hengst et al.   MOLECULAR MICROBIOLOGY

CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

(2010) Luciano A. Marraffini et al.   NATURE REVIEWS GENETICS

Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes

(2010) L. C. Foulston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improvement in doxorubicin productivity by overexpression of regulatory genes in Streptomyces peucetius

(2010) Sailesh Malla et al.   RESEARCH IN MICROBIOLOGY

The tmRNA-tagging mechanism and the control of gene expression: a review

(2010) Sharief Barends et al.   Wiley Interdisciplinary Reviews-RNA

Cross-talk of global nutritional regulators in the control of primary and secondary metabolism in Streptomyces

(2010) Juan F Martín et al.   Microbial Biotechnology

Engineered Streptomyces platensis Strains That Overproduce Antibiotics Platensimycin and Platencin

(2009) M. J. Smanski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Streptomyces Development in Colonies and Soils

(2009) A. Manteca et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of rrdA, a TetR Family Protein Gene Involved in the Regulation of Secondary Metabolism in Streptomyces coelicolor

(2009) X. Ou et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Industrial systems biology

(2009) José Manuel Otero et al.   BIOTECHNOLOGY AND BIOENGINEERING

Analysis of Two Additional Signaling Molecules in Streptomyces coelicolor and the Development of a Butyrolactone-Specific Reporter System

(2009) Nai-Hua Hsiao et al.   CHEMISTRY & BIOLOGY

Mass spectrometry based metabolomics and enzymatic assays for functional genomics

(2009) Richard Baran et al.   CURRENT OPINION IN MICROBIOLOGY

Direct methods for studying transcription regulatory proteins and RNA polymerase in bacteria

(2009) David C Grainger et al.   CURRENT OPINION IN MICROBIOLOGY

Transfer–messenger RNA controls the translation of cell-cycle and stress proteins in Streptomyces

(2009) Sharief Barends et al.   EMBO REPORTS

Two overlapping antiparallel genes encoding the iron regulator DmdR1 and the Adm proteins control sidephore and antibiotic biosynthesis in Streptomyces coelicolor A3(2)

(2009) Sedef Tunca et al.   FEBS Journal

Transcriptomics analyses reveal global roles of the regulator AveI inStreptomyces avermitilis

(2009) Lei Chen et al.   FEMS MICROBIOLOGY LETTERS

The synthesis and function of the alarmone (p)ppGpp in firmicutes

(2009) Christiane Wolz et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Role of nsdA in negative regulation of antibiotic production and morphological differentiation in Streptomyces bingchengensis

(2009) Xiang-Jing Wang et al.   JOURNAL OF ANTIBIOTICS

The Zinc-Responsive Regulator Zur Controls Expression of the Coelibactin Gene Cluster in Streptomyces coelicolor

(2009) D. Kallifidas et al.   JOURNAL OF BACTERIOLOGY

Mass spectrometric screening of transcriptional regulators involved in antibiotic biosynthesis in Streptomyces coelicolor A3(2)

(2009) Sung-Soo Park et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Antitumor Compounds from Marine Actinomycetes

(2009) Carlos Olano et al.   Marine Drugs

PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis

(2009) Cláudia M Vicente et al.   Microbial Cell Factories

SigN is responsible for differentiation and stress responses based on comparative proteomic analyses of Streptomyces coelicolor wild-type and sigN deletion strains

(2009) Chunxia Wang et al.   MICROBIOLOGICAL RESEARCH

DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus

(2009) H. Hara et al.   MICROBIOLOGY-SGM

Lack of A-factor Production Induces the Expression of Nutrient Scavenging and Stress-related Proteins inStreptomyces griseus

(2009) Zsuzsanna Birkó et al.   MOLECULAR & CELLULAR PROTEOMICS

Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone inStreptomyces antibioticus

(2009) Tung B. K. Le et al.   MOLECULAR MICROBIOLOGY

Dynamic changes in the extracellular proteome caused by absence of a pleiotropic regulator AdpA inStreptomyces griseus

(2009) Genki Akanuma et al.   MOLECULAR MICROBIOLOGY

The role of absC, a novel regulatory gene for secondary metabolism, in zinc-dependent antibiotic production in Streptomyces coelicolor A3(2)

(2009) Andy Hesketh et al.   MOLECULAR MICROBIOLOGY

The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) σ factor protein family

(2009) Anna Staroń et al.   MOLECULAR MICROBIOLOGY

Cross-talk between two global regulators in Streptomyces: PhoP and AfsR interact in the control of afsS, pstS and phoRP transcription

(2009) Fernando Santos-Beneit et al.   MOLECULAR MICROBIOLOGY

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs

(2009) Edmund I. Graziani   NATURAL PRODUCT REPORTS

Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis

(2009) Carlos Olano et al.   NATURAL PRODUCT REPORTS

New natural product biosynthetic chemistry discovered by genome mining

(2009) Christophe Corre et al.   NATURAL PRODUCT REPORTS

A proteomics approach to discovering natural products and their biosynthetic pathways

(2009) Stefanie B Bumpus et al.   NATURE BIOTECHNOLOGY

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

(2009) Takeshi Hosaka et al.   NATURE BIOTECHNOLOGY

DNA sampling: a method for probing protein binding at specific loci on bacterial chromosomes

(2009) Matej Butala et al.   NUCLEIC ACIDS RESEARCH

Phosphate control over nitrogen metabolism in Streptomyces coelicolor: direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP

(2009) Antonio Rodríguez-García et al.   NUCLEIC ACIDS RESEARCH

The SmpB-tmRNA Tagging System Plays Important Roles in Streptomyces coelicolor Growth and Development

(2009) Chunzhong Yang et al.   PLoS One

Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator

(2009) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR-based adaptive and heritable immunity in prokaryotes

(2009) John van der Oost et al.   TRENDS IN BIOCHEMICAL SCIENCES

Actinobacteria as mutualists: general healthcare for insects?

(2009) Martin Kaltenpoth   TRENDS IN MICROBIOLOGY

(p)ppGpp: Still Magical?

(2008) Katarzyna Potrykus et al.   Annual Review of Microbiology

Biology oftrans-Translation

(2008) Kenneth C. Keiler   Annual Review of Microbiology

The SsgA-like proteins in actinomycetes: small proteins up to a big task

(2008) Bjørn A. Traag et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations

(2008) G. Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Finding new pathway-specific regulators by clustering method using threshold standard deviation based on DNA chip data of Streptomyces coelicolor

(2008) Yung-Hun Yang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

NdgR, an IclR-like regulator involved in amino-acid-dependent growth, quorum sensing, and antibiotic production in Streptomyces coelicolor

(2008) Yung-Hun Yang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

afsQ1-Q2-sigQ is a pleiotropic but conditionally required signal transduction system for both secondary metabolism and morphological development in Streptomyces coelicolor

(2008) Dan Shu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165

(2008) Lei Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characteristics of the surface-located carbohydrate-binding protein CbpC from Streptomyces coelicolor A3(2)

(2008) Stefan Walter et al.   ARCHIVES OF MICROBIOLOGY

A DNA-binding factor, ArfA, interacts with the bldH promoter and affects undecylprodigiosin production in Streptomyces lividans

(2008) Delin Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2)

(2008) Wei Lian et al.   BMC GENOMICS

Control of bacterial transcription, translation and replication by (p)ppGpp

(2008) Anjana Srivatsan et al.   CURRENT OPINION IN MICROBIOLOGY

Renaissance in antibacterial discovery from actinomycetes

(2008) R BALTZ   CURRENT OPINION IN PHARMACOLOGY

Combinatorial Biosynthesis, Metabolic Engineering and Mutasynthesis for the Generation of New Aminocoumarin Antibiotics

(2008) L. Heide et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Biosynthetic Engineering of Polyene Macrolides Towards Generation of Improved Antifungal and Antiparasitic Agents

(2008) Patrick Caffrey et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

(2008) Sébastien Rigali et al.   EMBO REPORTS

Regulation of nitrogen metabolism inMycobacterium tuberculosis: A comparison with mechanisms inCorynebacterium glutamicumandStreptomyces coelicolor

(2008) Catriona Harper et al.   IUBMB LIFE

Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350

(2008) Y. Ohnishi et al.   JOURNAL OF BACTERIOLOGY

Autoregulation of AbsB (RNase III) Expression in Streptomyces coelicolor by Endoribonucleolytic Cleavage of absB Operon Transcripts

(2008) W. Xu et al.   JOURNAL OF BACTERIOLOGY

Bacteria Possessing Two RelA/SpoT-Like Proteins Have Evolved a Specific Stringent Response Involving the Acyl Carrier Protein-SpoT Interaction

(2008) A. Battesti et al.   JOURNAL OF BACTERIOLOGY

Identification and Utility of FdmR1 as a Streptomyces Antibiotic Regulatory Protein Activator for Fredericamycin Production in Streptomyces griseus ATCC 49344 and Heterologous Hosts

(2008) Y. Chen et al.   JOURNAL OF BACTERIOLOGY

Antibiotic Overproduction inStreptomyces coelicolorA3(2) Mediated by Phosphofructokinase Deletion

(2008) Irina Borodina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The use of the rare UUA codon to define “Expression Space” for genes involved in secondary metabolism, development and environmental adaptation in Streptomyces

(2008) Keith F. Chater et al.   JOURNAL OF MICROBIOLOGY

Crystal Structures of the Streptomyces coelicolor TetR-Like Protein ActR Alone and in Complex with Actinorhodin or the Actinorhodin Biosynthetic Precursor (S)-DNPA

(2008) A.R. Willems et al.   JOURNAL OF MOLECULAR BIOLOGY

Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus

(2008) S. Hirano et al.   MICROBIOLOGY-SGM

Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp

(2008) J. P. Gomez-Escribano et al.   MICROBIOLOGY-SGM

Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster fromStreptomyces cattleya

(2008) Miriam Rodríguez et al.   MOLECULAR MICROBIOLOGY

Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production inStreptomyces coelicolor

(2008) Sean O'Rourke et al.   MOLECULAR MICROBIOLOGY

Carbon catabolite repression in bacteria: many ways to make the most out of nutrients

(2008) Boris Görke et al.   NATURE REVIEWS MICROBIOLOGY

Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium

(2008) Klas Flärdh et al.   NATURE REVIEWS MICROBIOLOGY

Target genes and structure of the direct repeats in the DNA-binding sequences of the response regulator PhoP in Streptomyces coelicolor

(2008) Alberto Sola-Landa et al.   NUCLEIC ACIDS RESEARCH

2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining

(2008) C. Corre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A putative secreted solute binding protein, SCO6569 is a possible AfsR2-dependent down-regulator of actinorhodin biosynthesis in Streptomyces coelicolor

(2008) Han-Na Lee et al.   PROCESS BIOCHEMISTRY

Signaling mechanisms for activation of extracytoplasmic function (ECF) sigma factors

(2007) Benjamin E. Brooks et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A complex role for the γ-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2)

(2003) Eriko Takano et al.   MOLECULAR MICROBIOLOGY