Enhanced production of validamycin A in Streptomyces hygroscopicus 5008 by engineering validamycin biosynthetic gene cluster

Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species

(2014) Tiago Beites et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Combined gene cluster engineering and precursor feeding to improve gougerotin production in Streptomyces graminearus

(2013) Lingjuan Jiang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

(2013) Kyu-Sang Hwang et al.   BIOTECHNOLOGY ADVANCES

Production of a novelO-methyl-isoflavone by regioselective sequential hydroxylation andO-methylation reactions inStreptomyces avermitilishost system

(2013) Kwon-Young Choi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Exogenous 1,4-butyrolactone stimulates A-factor-like cascade and validamycin biosynthesis inStreptomyces hygroscopicus5008

(2013) Gao-Yi Tan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens

(2013) Tao Zhu et al.   METABOLIC ENGINEERING

Temperature shift-induced reactive oxygen species enhanced validamycin A production in fermentation of Streptomyces hygroscopicus 5008

(2012) Zhen-Hua Wei et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Impact of nitrogen concentration on validamycin A production and related gene transcription in fermentation of Streptomyces hygroscopicus 5008

(2012) Zhen-Hua Wei et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Enhancement of validamycin A production by addition of ethanol in fermentation of Streptomyces hygroscopicus 5008

(2012) Wen-Wen Zhou et al.   BIORESOURCE TECHNOLOGY

Cloning, expression and medium optimization of validamycin glycosyltransferase from Streptomyces hygroscopicus var. jinggangensis for the biotransformation of validoxylamine A to produce validamycin A using free resting cells

(2012) Yongxian Fan et al.   BIORESOURCE TECHNOLOGY

Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus 5008

(2012) Hang Wu et al.   BMC GENOMICS

A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253

(2011) Won Seok Jung et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

ZouA, a Putative Relaxase, Is Essential for DNA Amplification in Streptomyces kanamyceticus

(2011) T. Murakami et al.   JOURNAL OF BACTERIOLOGY

Over-expression of UDP-glucose pyrophosphorylase increases validamycin A but decreases validoxylamine A production in Streptomyces hygroscopicus var. jinggangensis 5008

(2011) Xiang Zhou et al.   METABOLIC ENGINEERING

A system for the targeted amplification of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor

(2011) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced production of validamycin A by H2O2-induced reactive oxygen species in fermentation of Streptomyces hygroscopicus 5008

(2010) Zhen-Hua Wei et al.   BIORESOURCE TECHNOLOGY

Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production

(2010) Guojian Liao et al.   Microbial Cell Factories

Effect of fermentation temperature on validamycin A production by Streptomyces hygroscopicus 5008

(2009) Yueqiao Liao et al.   JOURNAL OF BIOTECHNOLOGY

Bacterial gene amplification: implications for the evolution of antibiotic resistance

(2009) Linus Sandegren et al.   NATURE REVIEWS MICROBIOLOGY

Spontaneous Amplification of the Actinorhodin Gene Cluster in Streptomyces coelicolor Involving Native Insertion Sequence IS466

(2008) E. M. Widenbrant et al.   JOURNAL OF BACTERIOLOGY