Activation and Products of the Cryptic Secondary Metabolite Biosynthetic Gene Clusters by Rifampin Resistance (rpoB) Mutations in Actinomycetes

Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism

(2013) D. K. Derewacz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

(2012) Kozo Ochi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A Magic Bullet for Antibiotic Discovery

(2012) Kozo Ochi et al.   CHEMISTRY & BIOLOGY

Chemical Perturbation of Secondary Metabolism Demonstrates Important Links to Primary Metabolism

(2012) Arryn Craney et al.   CHEMISTRY & BIOLOGY

Development of the ability to produce secondary metabolites in Streptomyces through the acquisition of erythromycin resistance

(2012) Yu Imai et al.   JOURNAL OF ANTIBIOTICS

Scandium Stimulates the Production of Amylase and Bacilysin in Bacillus subtilis

(2011) Takashi Inaoka et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Strain improvement in actinomycetes in the postgenomic era

(2011) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Rare earth elements activate the secondary metabolite–biosynthetic gene clusters in Streptomyces coelicolor A3(2)

(2010) Yukinori Tanaka et al.   JOURNAL OF ANTIBIOTICS

The G243D mutation (afsB mutation) in the principal sigma factor  HrdB alters intracellular ppGpp level and antibiotic production in Streptomyces coelicolor A3(2)

(2010) G. Wang et al.   MICROBIOLOGY-SGM

Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes

(2009) Y. Tanaka et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biosynthesis of Actinorhodin and Related Antibiotics: Discovery of Alternative Routes for Quinone Formation Encoded in the act Gene Cluster

(2009) Susumu Okamoto et al.   CHEMISTRY & BIOLOGY

Activation of secondary metabolite–biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus

(2009) Yukinori Tanaka et al.   JOURNAL OF ANTIBIOTICS

Regulation of the Bacillus subtilis Divergent yetL and yetM Genes by a Transcriptional Repressor, YetL, in Response to Flavonoids

(2009) K. Hirooka et al.   JOURNAL OF BACTERIOLOGY

Production improvement of antifungal, antitrypanosomal nucleoside sinefungin by rpoB mutation and optimization of resting cell system of Streptomyces incarnatus NRRL 8089

(2009) Koji Fukuda et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production

(2009) Elisabetta Carata et al.   Microbial Cell Factories

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

(2009) Takeshi Hosaka et al.   NATURE BIOTECHNOLOGY

Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations

(2008) G. Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350

(2008) Y. Ohnishi et al.   JOURNAL OF BACTERIOLOGY

Activation of Dormant Bacterial Genes byNonomuraeasp. Strain ATCC 39727 Mutant-Type RNA Polymerase

(2008) Adelfia Talà et al.   JOURNAL OF BACTERIOLOGY

A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea

(2008) C. Chng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA