Review article: short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders

Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies

(2018) Melanie Tramontano et al.   Nature Microbiology

In Vitro Digestion and Fermentation of Microencapsulated Tributyrin for the Delivery of Butyrate

(2017) Joseph D. Donovan et al.   JOURNAL OF FOOD SCIENCE

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

(2017) Gera Goverse et al.   JOURNAL OF IMMUNOLOGY

The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System

(2017) Agatha Schwarz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dietary fibre in Europe: current state of knowledge on definitions, sources, recommendations, intakes and relationships to health

(2017) Alison M. Stephen et al.   NUTRITION RESEARCH REVIEWS

Bio-electrolytic sensor for rapid monitoring of volatile fatty acids in anaerobic digestion process

(2017) Xiangdan Jin et al.   WATER RESEARCH

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial

(2017) Emanuel E. Canfora et al.   Scientific Reports

Randomised clinical study: inulin short-chain fatty acid esters for targeted delivery of short-chain fatty acids to the human colon

(2016) T. Polyviou et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods

(2016) Claire S Byrne et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC

(2016) Ronald Schilderink et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms

(2016) Y. D. Bhutia et al.   BIOCHEMICAL JOURNAL

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive MiceClinical Perspective

(2016) Francine Z. Marques et al.   CIRCULATION

Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men

(2016) C. M. van der Beek et al.   CLINICAL SCIENCE

Effect of butyrate enemas on gene expression profiles and endoscopic/histopathological scores of diverted colorectal mucosa: A randomized trial

(2016) Cristina Luceri et al.   DIGESTIVE AND LIVER DISEASE

Short-Chain Fatty Acid Acetate Stimulates Adipogenesis and Mitochondrial Biogenesis via GPR43 in Brown Adipocytes

(2016) Jiamiao Hu et al.   ENDOCRINOLOGY

The acute effects of inulin and resistant starch on postprandial serum short-chain fatty acids and second-meal glycemic response in lean and overweight humans

(2016) S Rahat-Rozenbloom et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Short-Chain Fatty Acids Regulate Cytokines and Th17/Treg Cells in Human Peripheral Blood Mononuclear Cellsin vitro

(2016) M. Asarat et al.   IMMUNOLOGICAL INVESTIGATIONS

Activation of Short and Long Chain Fatty Acid Sensing Machinery in the Ileum Lowers Glucose Productionin Vivo

(2016) Melika Zadeh-Tahmasebi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison and validation of 2 analytical methods for the determination of free fatty acids in dairy products by gas chromatography with flame ionization detection

(2016) David T. Mannion et al.   JOURNAL OF DAIRY SCIENCE

Chronically Elevated Levels of Short-Chain Fatty Acids Induce T Cell-Mediated Ureteritis and Hydronephrosis

(2016) J. Park et al.   JOURNAL OF IMMUNOLOGY

Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study

(2016) Eef Boets et al.   JOURNAL OF PHYSIOLOGY-LONDON

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

(2016) W Wu et al.   Mucosal Immunology

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids

(2016) Jung-ha Park et al.   PLoS One

Impact of dietary resistant starch type 4 on human gut microbiota and immunometabolic functions

(2016) Bijaya Upadhyaya et al.   Scientific Reports

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

(2016) Jian Tan et al.   Cell Reports

An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis

(2016) S Sivaprakasam et al.   Oncogenesis

Variable responses of human microbiomes to dietary supplementation with resistant starch

(2016) A. Venkataraman et al.   Microbiome

Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival

(2016) Stephanie R. Villa et al.   Scientific Reports

Microbial metabolite butyrate facilitates M2 macrophage polarization and function

(2016) Jian Ji et al.   Scientific Reports

Review article: insights into colonic protein fermentation, its modulation and potential health implications

(2015) C. K. Yao et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Lactobacillus acidophilus counteracts enteropathogenic E. coli-induced inhibition of butyrate uptake in intestinal epithelial cells

(2015) Anoop Kumar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue: a randomised clinical trial

(2015) Richard K. Le Leu et al.   BRITISH JOURNAL OF NUTRITION

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Effects of wheat bran extract rich in arabinoxylan oligosaccharides and resistant starch on overnight glucose tolerance and markers of gut fermentation in healthy young adults

(2015) Elin V. Johansson Boll et al.   EUROPEAN JOURNAL OF NUTRITION

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival

(2015) Ulf H. Beier et al.   FASEB JOURNAL

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo

(2015) Anika Fischer et al.   GUT

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Short-Chain Fatty Acids Regulate Secretion of IL-8 from Human Intestinal Epithelial Cell Linesin vitro

(2015) M. Asarat et al.   IMMUNOLOGICAL INVESTIGATIONS

Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap® System

(2015) Mirko Koziolek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia

(2015) M.K. Nøhr et al.   NEUROSCIENCE

Butyrate modulates bacterial adherence on LS174T human colorectal cells by stimulating mucin secretion and MAPK signaling pathway

(2015) Tae-Hwan Jung et al.   Nutrition Research and Practice

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Alcohol: A Nutrient with Multiple Salutary Effects

(2015) Henry Pownall et al.   Nutrients

A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout

(2015) Angélica T. Vieira et al.   Arthritis & Rheumatology

Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells

(2014) Antoaneta Belcheva et al.   CELL

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Abnormal fibre usage in UC in remission

(2014) Sally L James et al.   GUT

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Functional Properties of Vinegar

(2014) Nilgün H. Budak et al.   JOURNAL OF FOOD SCIENCE

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

You are what you eat

(2014) Harald Brüssow et al.   NATURE BIOTECHNOLOGY

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

CODEX-aligned dietary fiber definitions help to bridge the ‘fiber gap’

(2014) Julie Miller Jones   Nutrition Journal

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Links between diet, gut microbiota composition and gut metabolism

(2014) Harry J. Flint et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation

(2014) Chang H. Kim et al.   Immune Network

Consumption of cereal fiber, mixtures of whole grains and bran, and whole grains and risk reduction in type 2 diabetes, obesity, and cardiovascular disease

(2013) Susan S Cho et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fiber and Functional Gastrointestinal Disorders

(2013) Shanti Eswaran et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids

(2013) Gijs den Besten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Microencapsulated sodium butyrate administered to patients with diverticulosis decreases incidence of diverticulitis—a prospective randomized study

(2013) Lukasz Krokowicz et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Resistant Starch Induces Catabolic but Suppresses Immune and Cell Division Pathways and Changes the Microbiome in the Proximal Colon of Male Pigs

(2013) Daniëlle Haenen et al.   JOURNAL OF NUTRITION

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis

(2013) D. E. Threapleton et al.   BMJ-British Medical Journal

A novel nutrient sensing mechanism underlies substrate-induced regulation of monocarboxylate transporter-1

(2012) Alip Borthakur et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties

(2012) Jean-Michel Lecerf et al.   BRITISH JOURNAL OF NUTRITION

Growth, organic acids profile and sugar metabolism of Bifidobacterium lactis in co-culture with Streptococcus thermophilus: The inulin effect

(2012) Ricardo Pinheiro de Souza Oliveira et al.   FOOD RESEARCH INTERNATIONAL

Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon

(2012) Xiaolei Ze et al.   ISME Journal

Inhibition of butyrate uptake by the primary bile salt chenodeoxycholic acid in intestinal epithelial cells

(2012) Pedro Gonçalves et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Consumption of Breads Containing In Situ–Produced Arabinoxylan Oligosaccharides Alters Gastrointestinal Effects in Healthy Volunteers

(2012) Bram Damen et al.   JOURNAL OF NUTRITION

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

Butyrate esterified to starch is released in the human gastrointestinal tract

(2011) Julie M Clarke et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated rats

(2011) J. M. Clarke et al.   CARCINOGENESIS

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Influence of starter cultures on the antioxidant activity of kombucha beverage

(2011) Radomir V. Malbaša et al.   FOOD CHEMISTRY

The monocarboxylate transporter family-Role and regulation

(2011) Andrew P. Halestrap et al.   IUBMB LIFE

In Vitro Batch Fecal Fermentation Comparison of Gas and Short-Chain Fatty Acid Production Using “Slowly Fermentable” Dietary Fibers

(2011) Amandeep Kaur et al.   JOURNAL OF FOOD SCIENCE

Modulation of Th1/Th2 Balance by Lactobacillus Strains Isolated from Kimchi via Stimulation of Macrophage Cell Line J774A.1 In Vitro

(2011) Tae Joon Won et al.   JOURNAL OF FOOD SCIENCE

Fecal Butyrate Levels Vary Widely among Individuals but Are Usually Increased by a Diet High in Resistant Starch

(2011) Alexandra L. McOrist et al.   JOURNAL OF NUTRITION

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The use of a wireless motility device (SmartPill®) for the measurement of gastrointestinal transit time after a dietary fibre intervention

(2010) Derek Timm et al.   BRITISH JOURNAL OF NUTRITION

Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission

(2010) Henrike M. Hamer et al.   CLINICAL NUTRITION

Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers

(2010) C. L. Roberts et al.   GUT

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

(2010) Alan W Walker et al.   ISME Journal

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

(2010) Marco A.R. Vinolo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age

(2009) D Mariat et al.   BMC MICROBIOLOGY

Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-α

(2009) Kristin R. Freeland et al.   BRITISH JOURNAL OF NUTRITION

Acetate transport and utilization in the rat brain

(2009) Dinesh K. Deelchand et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Microbiota and SCFA in Lean and Overweight Healthy Subjects

(2009) Andreas Schwiertz et al.   Obesity

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

(2009) Kashan Ahmed et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effects of processing high amylose maize starches under controlled conditions on structural organisation and amylase digestibility

(2008) A. Htoon et al.   CARBOHYDRATE POLYMERS

Linking phylogenetic identities of bacteria to starch fermentation in anin vitromodel of the large intestine by RNA-based stable isotope probing

(2008) Petia Kovatcheva-Datchary et al.   ENVIRONMENTAL MICROBIOLOGY

Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon

(2008) Markus Waldecker et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Alcohol Consumption by Aging Adults in the United States: Health Benefits and Detriments

(2008) Maria Pontes Ferreira et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Fructooligosaccharides exhibit more rapid fermentation than long-chain inulin in an in vitro fermentation system

(2008) Maria L. Stewart et al.   NUTRITION RESEARCH

Butyrate and trichostatin A attenuate nuclear factor κB activation and tumor necrosis factor α secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells

(2008) Makoto Usami et al.   NUTRITION RESEARCH