Therapeutic targeting of nuclear export and import receptors in cancer and their potential in combination chemotherapy

Karyopherin Subunit Alpha 1 Enhances the Malignant Behaviors of Colon Cancer Cells via Promoting Nuclear Factor-κB p65 Nuclear Translocation

(2023) Lianrong Zhao et al.   DIGESTIVE DISEASES AND SCIENCES

Azacitidine Is Synergistically Lethal with XPO1 Inhibitor Selinexor in Acute Myeloid Leukemia by Targeting XPO1/eIF4E/c-MYC Signaling

(2023) Huideng Long et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selinexor as Novel Inhibitor of DNA Damage Response in Merkel Cell Carcinoma

(2022) Stephen A. Moore et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Selective inhibition of nuclear export: a promising approach in the shifting treatment paradigms for hematological neoplasms

(2022) Suresh Kumar Balasubramanian et al.   LEUKEMIA

Venetoclax enhances DNA damage induced by XPO1 inhibitors: A novel mechanism underlying the synergistic antileukaemic effect in acute myeloid leukaemia

(2022) Hanxi Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Selinexor improves the anti-cancer effect of tucidinostat on TP53 wild-type breast cancer

(2022) Yingfang Shi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present

(2022) Patriciu Achimas-Cadariu et al.   Journal of Ovarian Research

Combining selinexor with alisertib to target the p53 pathway in neuroblastoma

(2022) Rosa Nguyen et al.   NEOPLASIA

Tumor-promoting properties of karyopherin β1 in melanoma by stabilizing Ras-GTPase-activating protein SH3 domain-binding protein 1

(2022) Fan Yang et al.   CANCER GENE THERAPY

Inhibition of karyopherin β1-mediated nuclear import disrupts oncogenic lineage- defining transcription factor activity in small cell lung cancer

(2022) Demetra P. Kelenis et al.   CANCER RESEARCH

Enhancement of MDM2 inhibitory effects through blocking nuclear export mechanisms in ovarian cancer cells

(2022) Amal Alzahrani et al.   Cancer Genetics

Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance

(2022) Kristina B. Emdal et al.   Cell Reports

Inhibition of XPO1 impairs cholangiocarcinoma cell proliferation by triggering p53 intranuclear accumulation

(2022) Cheng Zhao et al.   Cancer Medicine

GPER-mediated stabilization of HIF-1α contributes to upregulated aerobic glycolysis in tamoxifen-resistant cells

(2022) Yue Zhang et al.   ONCOGENE

XPO1 inhibition synergizes with PARP1 inhibition in small cell lung cancer by targeting nuclear transport of FOXO3a

(2021) Jingya Wang et al.   CANCER LETTERS

Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer

(2021) Ru-pin Alicia Chi et al.   BMC CANCER

Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies

(2021) Kai-long Jiang et al.   ACTA PHARMACOLOGICA SINICA

Novel small molecule inhibitor of Kpnβ1 induces cell cycle arrest and apoptosis in cancer cells

(2021) Aderonke Ajayi-Smith et al.   EXPERIMENTAL CELL RESEARCH

Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer

(2021) Akira Inoue et al.   GASTROENTEROLOGY

Clinical acquired resistance to KRASG12C inhibition through a novel KRAS switch-II pocket mutation and polyclonal alterations converging on RAS-MAPK reactivation

(2021) Noritaka Tanaka et al.   Cancer Discovery

Repositioning of Antiparasitic Drugs for Tumor Treatment

(2021) Yan-Qi Li et al.   Frontiers in Oncology

TNPO1-mediated nuclear import of ARID1B promotes tumor growth in ARID1A-deficient gynecologic cancer

(2021) Bikang Yang et al.   CANCER LETTERS

Metabolic reprograming confers tamoxifen resistance in breast cancer

(2021) Alok Mishra et al.   CHEMICO-BIOLOGICAL INTERACTIONS

XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IkB

(2021) Basia Galinski et al.   Translational Oncology

Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status

(2021) Hélène Marijon et al.   Oncotarget

Circular RNA circ-TNPO3 suppresses metastasis of gastric cancer by acting as a protein decoy for IGF2BP3 to regulate the expression of MYC and SNAIL

(2021) Ting Yu et al.   Molecular Therapy-Nucleic Acids

Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy

(2021) Alvaro Quintanal-Villalonga et al.   CANCER RESEARCH

Anti-tumor activity of the pan-RAF inhibitor TAK-580 in combination with KPT-330 (selinexor) in multiple myeloma

(2021) Rikio Suzuki et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer

(2021) Narmeen S. Rashid et al.   Translational Oncology

Pan-cancer analysis reveals the roles of XPO1 in predicting prognosis and tumorigenesis

(2021) Lei Zhao et al.   Translational Cancer Research

KPNA1 regulates nuclear import of NCOR2 splice variant BQ323636.1 to confer tamoxifen resistance in breast cancer

(2021) Ho Tsoi et al.   Clinical and Translational Medicine

Selinexor for the treatment of multiple myeloma

(2020) Klaus Podar et al.   EXPERT OPINION ON PHARMACOTHERAPY

Identification of Prognostic Dosage-Sensitive Genes in Colorectal Cancer Based on Multi-Omics

(2020) Zhiqiang Chang et al.   Frontiers in Genetics

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

Efficient Suppression of NRAS-Driven Melanoma by Co-inhibition of ERK1/2 and ERK5 MAPK Pathways

(2020) Christian Adam et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Small Molecule Inhibitors of CRM1

(2020) Bibiana I. Ferreira et al.   Frontiers in Pharmacology

Response of Breast Cancer Cells to PARP Inhibitors Is Independent of BRCA Status

(2020) Man Yee Keung et al.   Journal of Clinical Medicine

Targeting nuclear import and export in hematological malignancies

(2020) Boaz Nachmias et al.   LEUKEMIA

Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation

(2020) Jordan M. Baumhardt et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibiting Importin 4-mediated nuclear import of CEBPD enhances chemosensitivity by repression of PRKDC-driven DNA damage repair in cervical cancer

(2020) Yang Zhou et al.   ONCOGENE

G3BP1 interacts with YWHAZ to regulate chemoresistance and predict adjuvant chemotherapy benefit in gastric cancer

(2020) Junjie Zhao et al.   BRITISH JOURNAL OF CANCER

Melphalan and exportin 1 inhibitors exert synergistic anti-tumor effects in preclinical models of human multiple myeloma

(2020) Joel G Turner et al.   CANCER RESEARCH

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

(2020) Rui Liu et al.   Cell Death & Disease

Inhibition of Karyopherin beta 1 suppresses prostate cancer growth

(2019) Jian Yang et al.   ONCOGENE

Importin-4 functions as a driving force in human primary gastric cancer

(2019) Xia Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A Phase II Trial of Selinexor (KPT‐330) for Metastatic Triple‐Negative Breast Cancer

(2019) Michael Shafique et al.   ONCOLOGIST

Inhibitors of nuclear transport

(2019) David A Jans et al.   CURRENT OPINION IN CELL BIOLOGY

Altered nuclear export signal recognition as a driver of oncogenesis

(2019) Justin Taylor et al.   Cancer Discovery

pCRM1exportome: database of predicted CRM1-dependent Nuclear Export Signal (NES) motifs in cancer-related genes

(2019) Yoonji Lee et al.   BIOINFORMATICS

Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region

(2019) Annalisa Verrico et al.   ONCOGENE

Treatment Options for Triple-class Refractory Multiple Myeloma

(2019) Joseph Mikhael   Clinical Lymphoma Myeloma & Leukemia

CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity

(2019) Youzhou Sang et al.   Nature Communications

TNPO2 operates downstream of DYNC1I1 and promotes gastric cancer cell proliferation and inhibits apoptosis

(2019) Libao Gong et al.   Cancer Medicine

POM121 overexpression is related to a poor prognosis in colorectal cancer

(2019) Tengqi Wang et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Expression of HIF-1α is related to a poor prognosis and tamoxifen resistance in contralateral breast cancer

(2019) Annika Jögi et al.   PLoS One

Inhibition of KPNB1 Inhibits Proliferation and Promotes Apoptosis of Chronic Myeloid Leukemia Cells Through Regulation of E2F1

(2019) Teng Wang et al.   OncoTargets and Therapy

Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress

(2018) Jiaqiao Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models

(2018) Cristina Corno et al.   BIOCHEMICAL PHARMACOLOGY

STAT6 is a cargo of exportin 1: Biological relevance in primary mediastinal B-cell lymphoma

(2018) Hadjer Miloudi et al.   CELLULAR SIGNALLING

BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen Resistant Breast Cancer

(2018) Chun Gong et al.   CLINICAL CANCER RESEARCH

Karyopherins in cancer

(2018) Tolga Çağatay et al.   CURRENT OPINION IN CELL BIOLOGY

KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells

(2018) Zhi-Chuan Zhu et al.   ONCOGENE

ARID1A loss in cancer: Towards a mechanistic understanding

(2018) Radhika Mathur   PHARMACOLOGY & THERAPEUTICS

High Kpnβ1 expression promotes non-small cell lung cancer proliferation and chemoresistance via the PI3-kinase/AKT pathway

(2018) Haiying Wang et al.   TISSUE & CELL

Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents

(2018) Trinayan Kashyap et al.   Oncotarget

Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import

(2018) Veronica Rodriguez-Bravo et al.   CELL

Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor

(2018) Vinod Vijay Subhash et al.   Scientific Reports

Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems

(2018) Enyuan Shang et al.   Scientific Reports

Survival of patients with advanced metastatic melanoma: the impact of novel therapies–update 2017

(2017) Selma Ugurel et al.   EUROPEAN JOURNAL OF CANCER

The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein

(2017) Muhan Chen et al.   JOURNAL OF CELL BIOLOGY

Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1

(2017) A Cosson et al.   LEUKEMIA

Targeted agents and immunotherapies: optimizing outcomes in melanoma

(2017) Jason J. Luke et al.   Nature Reviews Clinical Oncology

In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer

(2017) Michiko Kodama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Exportin-1–dependent microRNA biogenesis pathway during human cell quiescence

(2017) Ivan Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery

(2017) Laurent Volpon et al.   RNA

KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells

(2017) Tamara Stelma et al.   Oncotarget

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

The molecular mechanisms of chemoresistance in cancers

(2017) Hua-Chuan Zheng   Oncotarget

Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells

(2017) Rand Arafeh et al.   Scientific Reports

Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma

(2016) Fabrice Jardin et al.   AMERICAN JOURNAL OF HEMATOLOGY

Negative feedback regulation of the ERK1/2 MAPK pathway

(2016) David Lake et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of KPNB1 as a Cellular Target of Aminothiazole Derivatives with Anticancer Activity

(2016) Yong-Hak Kim et al.   ChemMedChem

Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer

(2016) Ying Chen et al.   CLINICAL CANCER RESEARCH

XPO1 Inhibition using Selinexor Synergizes with Chemotherapy in Acute Myeloid Leukemia by Targeting DNA Repair and Restoring Topoisomerase II  to the Nucleus

(2016) P. Ranganathan et al.   CLINICAL CANCER RESEARCH

Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma

(2016) V. Camus et al.   HAEMATOLOGICA

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential

(2016) Tamara Stelma et al.   IUBMB LIFE

Treatment of acquired drug resistance in multiple myeloma by combination therapy with XPO1 and topoisomerase II inhibitors

(2016) Joel G. Turner et al.   Journal of Hematology & Oncology

KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells

(2016) J Etchin et al.   LEUKEMIA

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies

(2016) Z A Hing et al.   LEUKEMIA

Targeting the Nuclear Import Receptor Kpn 1 as an Anticancer Therapeutic

(2016) P. J. van der Watt et al.   MOLECULAR CANCER THERAPEUTICS

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

(2016) Trinayan Kashyap et al.   Oncotarget

XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma

(2016) Joel G. Turner et al.   Oncotarget

Preclinical activity of selinexor, an inhibitor of XPO1, in sarcoma

(2016) Robert Nakayama et al.   Oncotarget

Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma

(2016) V. Camus et al.   HAEMATOLOGICA

Synthesis and Biological Evaluation of 2-Aminothiazole Derivative Having Anticancer Activity as a KPNB1 Inhibitor

(2016) Siyoung Ha et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

ER stress: Autophagy induction, inhibition and selection

(2015) Harun-Or Rashid et al.   Autophagy

Hyper-dependence of breast cancer cell types on the nuclear transporter Importin β1

(2015) Henna V. Kuusisto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways

(2015) Friederike K. Kosyna et al.   BIOLOGICAL CHEMISTRY

Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds

(2015) Marsha Crochiere et al.   BMC CANCER

Importin β1 mediates nuclear factor-κB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis

(2015) Wenqing Yan et al.   CELLULAR SIGNALLING

Nuclear transport factors: global regulation of mitosis

(2015) Douglass J Forbes et al.   CURRENT OPINION IN CELL BIOLOGY

Upregulation of nuclear transporter, Kpnβ1, contributes to accelerated cell proliferation- and cell adhesion-mediated drug resistance (CAM-DR) in diffuse large B-cell lymphoma

(2015) Song He et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

(2015) Shundong Cang et al.   Journal of Hematology & Oncology

Overexpression of CRM1: A Characteristic Feature in a Transformed Phenotype of Lung Carcinogenesis and a Molecular Target for Lung Cancer Adjuvant Therapy

(2015) Weimin Gao et al.   Journal of Thoracic Oncology

Suppression of the nuclear transporter-KPNβ1 expression inhibits tumor proliferation in hepatocellular carcinoma

(2015) Linlin Yang et al.   MEDICAL ONCOLOGY

Selective Nuclear Export Inhibitor KPT-330 Enhances the Antitumor Activity of Gemcitabine in Human Pancreatic Cancer

(2015) S. Kazim et al.   MOLECULAR CANCER THERAPEUTICS

Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185

(2015) Yoko Tabe et al.   PLoS One

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

(2015) Joel D. Leverson et al.   Science Translational Medicine

Upregulation of KPNβ1 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis

(2015) Jia Zhu et al.   TUMOR BIOLOGY

The nuclear translocation of ERK1/2 as an anticancer target

(2015) Alexander Plotnikov et al.   Nature Communications

Tracking the Genomic Evolution of Esophageal Adenocarcinoma through Neoadjuvant Chemotherapy

(2015) N. Murugaesu et al.   Cancer Discovery

Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin

(2015) Michelandrea De Cesare et al.   Oncotarget

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

(2015) Koray Kırlı et al.   eLife

Targeting nucleocytoplasmic transport in cancer therapy

(2015) Richard Hill et al.   Oncotarget

KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma

(2014) Yun Zheng et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma

(2014) Mariko Yoshimura et al.   CANCER SCIENCE

Inhibition of the nuclear transporter, Kpnβ1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in cervical cancer cells

(2014) Liselotte Angus et al.   CARCINOGENESIS

Transportin-1 and Transportin-2: Protein nuclear import and beyond

(2014) Laure Twyffels et al.   FEBS LETTERS

Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration

(2014) Cyril Bernis et al.   MOLECULAR BIOLOGY OF THE CELL

CBS9106-Induced CRM1 Degradation Is Mediated by Cullin Ring Ligase Activity and the Neddylation Pathway

(2014) N. Saito et al.   MOLECULAR CANCER THERAPEUTICS

Genomic and molecular characterization of esophageal squamous cell carcinoma

(2014) De-Chen Lin et al.   NATURE GENETICS

Elevated expression of the nuclear export protein, Crm1 (exportin 1), associates with human oesophageal squamous cell carcinoma

(2014) PAULINE J. VAN DER WATT et al.   ONCOLOGY REPORTS

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Prognostic impact and targeting of CRM1 in acute myeloid leukemia

(2013) K. Kojima et al.   BLOOD

Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276

(2013) J Schmidt et al.   LEUKEMIA

CRM1 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas

(2013) Fang Zhou et al.   MEDICAL ONCOLOGY

Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy

(2013) P. Godwin et al.   Frontiers in Oncology

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

(2012) Guoliang Qing et al.   CANCER CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

The cellular apoptosis susceptibility CAS/CSE1L gene protects ovarian cancer cells from death by suppressing RASSF1C

(2012) Annalisa Lorenzato et al.   FASEB JOURNAL

Transient Aggregation of Ubiquitinated Proteins Is a Cytosolic Unfolded Protein Response to Inflammation and Endoplasmic Reticulum Stress

(2012) Xian-De Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores

(2012) Emanuele Roscioli et al.   JOURNAL OF CELL BIOLOGY

Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors

(2012) Ori Kalid et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

CRM1 Blockade by Selective Inhibitors of Nuclear Export Attenuates Kidney Cancer Growth

(2012) Hiromi Inoue et al.   JOURNAL OF UROLOGY

Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis

(2012) Lior Golomb et al.   MOLECULAR CELL

Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β

(2011) Jonathan F. Soderholm et al.   ACS Chemical Biology

The nuclear exporter, Crm1, is regulated by NFY and Sp1 in cancer cells and repressed by p53 in response to DNA damage

(2011) Pauline J. van der Watt et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Global enhancement of nuclear localization-dependent nuclear transport in transformed cells

(2011) Henna V. Kuusisto et al.   FASEB JOURNAL

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

(2011) Siwanon Jirawatnotai et al.   NATURE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Resistance to BRAF Inhibition in Melanomas

(2011) David B. Solit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dynamics of the STAT3 Transcription Factor: Nuclear Import Dependent on Ran and Importin-β1

(2011) Velasco Cimica et al.   PLoS One

Overexpression of Kpnβ1 and Kpnα2 Importin Proteins in Cancer Derives from Deregulated E2F Activity

(2011) Pauline J. van der Watt et al.   PLoS One

c-MYC Suppresses BIN1 to Release Poly(ADP-Ribose) Polymerase 1: A Mechanism by Which Cancer Cells Acquire Cisplatin Resistance

(2011) S. Pyndiah et al.   Science Signaling

mRNA export and cancer

(2011) Nadeem Siddiqui et al.   Wiley Interdisciplinary Reviews-RNA

Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries

(2010) Martin Hintersteiner et al.   ACS Chemical Biology

Tumor Cell Kill by c-MYC Depletion: Role of MYC-Regulated Genes that Control DNA Double-Strand Break Repair

(2010) K. R. Luoto et al.   CANCER RESEARCH

Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells

(2010) Marilena Ciciarello et al.   CHROMOSOMA

Anti-apoptotic Protein BCL2 Down-regulates DNA End Joining in Cancer Cells

(2010) Tadi Satish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A fraction of Crm1 locates at centrosomes by its CRIME domain and regulates the centrosomal localization of pericentrin

(2009) Qinying Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human Multiple Myeloma Cells Are Sensitized to Topoisomerase II Inhibitors by CRM1 Inhibition

(2009) J. G. Turner et al.   CANCER RESEARCH

PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers

(2009) S. Wee et al.   CANCER RESEARCH

Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition

(2009) O. K. Mirzoeva et al.   CANCER RESEARCH

Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors

(2009) J.-M. Mingot et al.   JOURNAL OF CELL SCIENCE

EXPRESSION OF CRM1 IN HUMAN GLIOMAS AND ITS SIGNIFICANCE IN P27 EXPRESSION AND CLINICAL PROGNOSIS

(2009) Aiguo Shen et al.   NEUROSURGERY

Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer

(2008) Aurelia Noske et al.   CANCER

The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation

(2008) Pauline J. van der Watt et al.   INTERNATIONAL JOURNAL OF CANCER

The RanGTP gradient - a GPS for the mitotic spindle

(2008) P. Kalab et al.   JOURNAL OF CELL SCIENCE

Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage

(2008) X. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA