Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185

Shock about heat shock in cancer

(2015) Emmanuel de Billy et al.   Oncotarget

Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma

(2014) Mariko Yoshimura et al.   CANCER SCIENCE

Nucleo-cytoplasmic transport as a therapeutic target of cancer

(2014) Giovanni Luca Gravina et al.   Journal of Hematology & Oncology

Antitumor Effects of a Novel Chromosome Region Maintenance 1 (CRM1) Inhibitor on Non-Small Cell Lung Cancer Cells In Vitro and in Mouse Tumor Xenografts

(2014) Shuai Wang et al.   PLoS One

Class IA Phosphatidylinositol 3-Kinase Inhibition Inhibits Cell Growth and Proliferation in Mantle Cell Lymphoma

(2013) Yoko Tabe et al.   ACTA HAEMATOLOGICA

Prognostic impact and targeting of CRM1 in acute myeloid leukemia

(2013) K. Kojima et al.   BLOOD

Selective inhibitors of nuclear export for the treatment of non-Hodgkin's lymphomas

(2013) A. S. Azmi et al.   HAEMATOLOGICA

CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications

(2013) Y-T Tai et al.   LEUKEMIA

Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma

(2013) Rami Rahal et al.   NATURE MEDICINE

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

(2013) S. Santagata et al.   SCIENCE

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

(2012) R. Lapalombella et al.   BLOOD

Ribosome Biogenesis and Control of Cell Proliferation: p53 Is Not Alone

(2012) G. Donati et al.   CANCER RESEARCH

Clonal heterogeneity of mantle cell lymphoma revealed by array comparative genomic hybridization

(2012) Fang Liu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma

(2012) Kejie Zhang et al.   EXPERIMENTAL HEMATOLOGY

Statistical Inference from Multiple iTRAQ Experiments without Using Common Reference Standards

(2012) Shelley M. Herbrich et al.   JOURNAL OF PROTEOME RESEARCH

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

(2012) J Etchin et al.   LEUKEMIA

NESdb: a database of NES-containing CRM1 cargoes

(2012) Darui Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Translational Homeostasis via eIF4E and 4E-BP1

(2012) Alan G. Hinnebusch   MOLECULAR CELL

PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma

(2011) C. Gomez-Abad et al.   BLOOD

Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation

(2011) Giulio Donati et al.   JOURNAL OF CELL SCIENCE

Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era

(2010) P. Perez-Galan et al.   BLOOD

Effect of Long-term Storage in TRIzol on Microarray-Based Gene Expression Profiling

(2010) W. Ma et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Recognition of nuclear targeting signals by Karyopherin-β proteins

(2010) Darui Xu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit

(2010) Jayati Sengupta et al.   JOURNAL OF CELL BIOLOGY

PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression

(2010) V Iadevaia et al.   ONCOGENE

Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: Discovery of a new leucine-rich nuclear export signal site

(2009) Masashi Fukasawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Identification of Nuclear Export Inhibitors with Potent Anticancer Activity In vivo

(2009) S. C. Mutka et al.   CANCER RESEARCH

Down-regulation of pescadillo inhibits proliferation and tumorigenicity of breast cancer cells

(2009) Jun Li et al.   CANCER SCIENCE

Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

(2009) Ivan Topisirovic et al.   EMBO JOURNAL

Transcriptional targets for pituitary tumor-transforming gene-1

(2009) Yunguang Tong et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data

(2009) Nuno L. Barbosa-Morais et al.   NUCLEIC ACIDS RESEARCH

The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation

(2009) X. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intensive treatment strategies may not provide superior outcomes in mantle cell lymphoma: overall survival exceeding 7 years with standard therapies

(2008) P. Martin et al.   ANNALS OF ONCOLOGY

iTRAQ-Facilitated Proteomic Analysis of Human Prostate Cancer Cells Identifies Proteins Associated with Progression

(2008) Adam Glen et al.   JOURNAL OF PROTEOME RESEARCH

mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation

(2008) Feng Hong et al.   MOLECULAR CELL

Enhanced identification and biological validation of differential gene expression via Illumina whole-genome expression arrays through the use of the model-based background correction methodology

(2008) Liang-Hao Ding et al.   NUCLEIC ACIDS RESEARCH