KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma
出版年份 2014 全文链接
标题
KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma
作者
关键词
Hepatocellular carcinoma, XPO1 inhibitor, Apoptosis, Xenograft
出版物
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Volume 74, Issue 3, Pages 487-495
出版商
Springer Nature
发表日期
2014-07-16
DOI
10.1007/s00280-014-2495-8
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Prognostic impact and targeting of CRM1 in acute myeloid leukemia
- (2013) K. Kojima et al. BLOOD
- Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias
- (2013) C. J. Walker et al. BLOOD
- KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia
- (2013) Julia Etchin et al. BRITISH JOURNAL OF HAEMATOLOGY
- Selective inhibitors of nuclear export for the treatment of non-Hodgkin's lymphomas
- (2013) A. S. Azmi et al. HAEMATOLOGICA
- Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276
- (2013) J Schmidt et al. LEUKEMIA
- CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications
- (2013) Y-T Tai et al. LEUKEMIA
- Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia
- (2012) R. Lapalombella et al. BLOOD
- Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia
- (2012) P. Ranganathan et al. BLOOD
- Abstract 2943: KPT-SINE (Selective Inhibitors of Nuclear Export) induce apoptosis in colon cancer cells in-vitro and in-vivo through nuclear localization of Tumor Suppressor Proteins (TSPs)
- (2012) William Senapedis et al. CANCER RESEARCH
- Selective Inhibitors of Nuclear Export Block Pancreatic Cancer Cell Proliferation and Reduce Tumor Growth in Mice
- (2012) Asfar S. Azmi et al. GASTROENTEROLOGY
- Role of sorafenib in the treatment of advanced hepatocellular carcinoma: An update
- (2012) Angela Gauthier et al. HEPATOLOGY RESEARCH
- Hepatocellular carcinoma
- (2012) Alejandro Forner et al. LANCET
- Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells
- (2012) J Etchin et al. LEUKEMIA
- NESdb: a database of NES-containing CRM1 cargoes
- (2012) Darui Xu et al. MOLECULAR BIOLOGY OF THE CELL
- ValidNESs: a database of validated leucine-rich nuclear export signals
- (2012) Szu-Chin Fu et al. NUCLEIC ACIDS RESEARCH
- Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth
- (2012) C Dudgeon et al. ONCOGENE
- Nuclear export of proteins and drug resistance in cancer
- (2011) Joel G. Turner et al. BIOCHEMICAL PHARMACOLOGY
- CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity
- (2011) K. Sakakibara et al. BLOOD
- Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli
- (2011) Joan Fernando et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Hepatocellular Carcinoma
- (2011) Hashem B. El-Serag NEW ENGLAND JOURNAL OF MEDICINE
- Hepatocellular Carcinoma: Novel Molecular Approaches for Diagnosis, Prognosis, and Therapy
- (2010) Augusto Villanueva et al. Annual Review of Medicine
- A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early-Stage Hepatocellular Carcinoma Patients
- (2010) S. Roessler et al. CANCER RESEARCH
- Recognition of nuclear targeting signals by Karyopherin-β proteins
- (2010) Darui Xu et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Structural basis for leucine-rich nuclear export signal recognition by CRM1
- (2009) Xiuhua Dong et al. NATURE
- EXPRESSION OF CRM1 IN HUMAN GLIOMAS AND ITS SIGNIFICANCE IN P27 EXPRESSION AND CLINICAL PROGNOSIS
- (2009) Aiguo Shen et al. NEUROSURGERY
- Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP
- (2009) T. Monecke et al. SCIENCE
- The mitochondrial p53 pathway
- (2008) Angelina V. Vaseva et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer
- (2008) Aurelia Noske et al. CANCER
- The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation
- (2008) Pauline J. van der Watt et al. INTERNATIONAL JOURNAL OF CANCER
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search