Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region

Inhibition of Karyopherin beta 1 suppresses prostate cancer growth

(2019) Jian Yang et al.   ONCOGENE

Karyopherins in cancer

(2018) Tolga Çağatay et al.   CURRENT OPINION IN CELL BIOLOGY

Visualization of human karyopherin beta-1/importin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays

(2018) Laura Di Francesco et al.   Scientific Reports

Importin-β and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function

(2017) Eugenia Gilistro et al.   JOURNAL OF CELL SCIENCE

The functional versatility of the nuclear pore complex proteins

(2017) Mohammed Hezwani et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules

(2017) Erica Di Cesare et al.   Oncotarget

Extensive cargo identification reveals distinct biological roles of the 12 importin pathways

(2017) Makoto Kimura et al.   eLife

Karyopherinβ1 regulates proliferation of human glioma cells via Wnt/β-catenin pathway

(2016) Ting Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The GTPase RAN regulates multiple steps of the centrosome life cycle

(2016) Patrizia Lavia   CHROMOSOME RESEARCH

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential

(2016) Tamara Stelma et al.   IUBMB LIFE

Structural Biology and Regulation of Protein Import into the Nucleus

(2016) Mary Christie et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting the Nuclear Import Receptor Kpn 1 as an Anticancer Therapeutic

(2016) P. J. van der Watt et al.   MOLECULAR CANCER THERAPEUTICS

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes

(2016) Tobias Ritterhoff et al.   Nature Communications

Mcl-1 dynamics influence mitotic slippage and death in mitosis

(2016) Olivia Sloss et al.   Oncotarget

The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways

(2015) Friederike K. Kosyna et al.   BIOLOGICAL CHEMISTRY

Importin β1 mediates nuclear factor-κB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis

(2015) Wenqing Yan et al.   CELLULAR SIGNALLING

Nuclear transport factors: global regulation of mitosis

(2015) Douglass J Forbes et al.   CURRENT OPINION IN CELL BIOLOGY

Upregulation of nuclear transporter, Kpnβ1, contributes to accelerated cell proliferation- and cell adhesion-mediated drug resistance (CAM-DR) in diffuse large B-cell lymphoma

(2015) Song He et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

RanGTP aids anaphase entry through Ubr5-mediated protein turnover

(2015) Hao Jiang et al.   JOURNAL OF CELL BIOLOGY

Suppression of the nuclear transporter-KPNβ1 expression inhibits tumor proliferation in hepatocellular carcinoma

(2015) Linlin Yang et al.   MEDICAL ONCOLOGY

SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer

(2015) Karolin Eifler et al.   TRENDS IN BIOCHEMICAL SCIENCES

Upregulation of KPNβ1 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis

(2015) Jia Zhu et al.   TUMOR BIOLOGY

The NOXA–MCL1–BIM axis defines lifespan on extended mitotic arrest

(2015) Manuel D. Haschka et al.   Nature Communications

miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells

(2014) Alessandro Rosa et al.   DEVELOPMENTAL BIOLOGY

Functional Genetic Screens Identify Genes Essential for Tumor Cell Survival in Head and Neck and Lung Cancer

(2013) S. R. Martens-de Kemp et al.   CLINICAL CANCER RESEARCH

The Nuclear Import Receptor Kpnβ1 and Its Potential as an AntiCancer Therapeutic Target

(2013) Pauline J. van der Watt et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Identification of Cargo Proteins Specific for Importin-β with Importin-α Applying a Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-basedin VitroTransport System

(2013) Makoto Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

(2013) J.-M. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores

(2012) Emanuele Roscioli et al.   JOURNAL OF CELL BIOLOGY

Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β

(2011) Jonathan F. Soderholm et al.   ACS Chemical Biology

The tyrosine kinase inhibitor sorafenib sensitizes hepatocellular carcinoma cells to taxol by suppressing the HURP protein

(2011) Tzu-Ching Kuo et al.   BIOCHEMICAL PHARMACOLOGY

Overexpression of Kpnβ1 and Kpnα2 Importin Proteins in Cancer Derives from Deregulated E2F Activity

(2011) Pauline J. van der Watt et al.   PLoS One

Regulated Degradation of Spindle Assembly Factors by the Anaphase-Promoting Complex

(2010) Ling Song et al.   MOLECULAR CELL

Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

(2010) Michael H. A. Schmitz et al.   NATURE CELL BIOLOGY

Quantitative Structural Analysis of Importin-β Flexibility: Paradigm for Solenoid Protein Structures

(2010) Jade K. Forwood et al.   STRUCTURE

Identification of a nuclear localization signal in the polo box domain of Plk1

(2009) Moon-Sing Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation

(2008) Pauline J. van der Watt et al.   INTERNATIONAL JOURNAL OF CANCER

Aurora A Regulates the Activity of HURP by Controlling the Accessibility of Its Microtubule-binding Domain

(2008) Jim Wong et al.   MOLECULAR BIOLOGY OF THE CELL