Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells
出版年份 2017 全文链接
标题
Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells
作者
关键词
-
出版物
Scientific Reports
Volume 7, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-11-21
DOI
10.1038/s41598-017-16558-0
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Targeted agents and immunotherapies: optimizing outcomes in melanoma
- (2017) Jason J. Luke et al. Nature Reviews Clinical Oncology
- Drugging RAS: Know the enemy
- (2017) Bjoern Papke et al. SCIENCE
- The ERK cascade inhibitors: Towards overcoming resistance
- (2016) Galia Maik-Rachline et al. DRUG RESISTANCE UPDATES
- Phenotypic Characterization of a Comprehensive Set of MAPK1 /ERK2 Missense Mutants
- (2016) Lisa Brenan et al. Cell Reports
- Genomic Classification of Cutaneous Melanoma
- (2015) Rehan Akbani et al. CELL
- Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts
- (2015) K. Kemper et al. EMBO Molecular Medicine
- Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas
- (2015) Michael Krauthammer et al. NATURE GENETICS
- Recurrent inactivating RASA2 mutations in melanoma
- (2015) Rand Arafeh et al. NATURE GENETICS
- Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
- (2015) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- The nuclear translocation of ERK1/2 as an anticancer target
- (2015) Alexander Plotnikov et al. Nature Communications
- Dragging Ras Back in the Ring
- (2014) Andrew G. Stephen et al. CANCER CELL
- ERKs in Cancer: Friends or Foes?
- (2014) Xavier Deschênes-Simard et al. CANCER RESEARCH
- Tumour heterogeneity and the evolution of polyclonal drug resistance
- (2014) Rebecca A. Burrell et al. Molecular Oncology
- Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma
- (2014) Chong Sun et al. NATURE
- Tumor heterogeneity and plasticity as elusive drivers for resistance to MAPK pathway inhibition in melanoma
- (2014) A Roesch ONCOGENE
- Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma
- (2013) Omid Hamid et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nivolumab plus Ipilimumab in Advanced Melanoma
- (2013) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
- (2013) H. Shi et al. Cancer Discovery
- Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors
- (2013) E. J. Morris et al. Cancer Discovery
- Cancer statistics, 2012
- (2012) Rebecca Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- The RAF Inhibitor Paradox Revisited
- (2012) Adrienne D. Cox et al. CANCER CELL
- Targeting NRAS in Melanoma
- (2012) Fergal C. Kelleher et al. CANCER JOURNAL
- Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells
- (2012) W.-B. Tsai et al. CANCER RESEARCH
- Phase II Study of the MEK1/MEK2 Inhibitor Trametinib in Patients With MetastaticBRAF-Mutant Cutaneous Melanoma Previously Treated With or Without a BRAF Inhibitor
- (2012) Kevin B. Kim et al. JOURNAL OF CLINICAL ONCOLOGY
- Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
- (2012) Ravid Straussman et al. NATURE
- Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
- (2012) Michael Krauthammer et al. NATURE GENETICS
- Progression of RAS-Mutant Leukemia during RAF Inhibitor Treatment
- (2012) Margaret K. Callahan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations
- (2012) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma
- (2012) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- RASMutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
- (2012) Fei Su et al. NEW ENGLAND JOURNAL OF MEDICINE
- MEK1 mutations, but not ERK2 mutations, occur in melanomas and colon carcinomas, but none in thyroid carcinomas
- (2011) Avaniyapuram Kannan Murugan et al. CELL CYCLE
- GSK1120212 (JTP-74057) Is an Inhibitor of MEK Activity and Activation with Favorable Pharmacokinetic Properties for Sustained In Vivo Pathway Inhibition
- (2011) A. G. Gilmartin et al. CLINICAL CANCER RESEARCH
- Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Translocation Is Mediated by Casein Kinase 2 and Accelerated by Autophosphorylation
- (2011) A. Plotnikov et al. MOLECULAR AND CELLULAR BIOLOGY
- RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
- (2011) Poulikos I. Poulikakos et al. NATURE
- Resistance to BRAF Inhibition in Melanomas
- (2011) David B. Solit et al. NEW ENGLAND JOURNAL OF MEDICINE
- The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation
- (2010) Alexander Plotnikov et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
- (2010) Christophe Frémin et al. Journal of Hematology & Oncology
- COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
- (2010) Cory M. Johannessen et al. NATURE
- Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
- (2010) Ramin Nazarian et al. NATURE
- Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
- (2010) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- RSK Is a Principal Effector of the RAS-ERK Pathway for Eliciting a Coordinate Promotile/Invasive Gene Program and Phenotype in Epithelial Cells
- (2009) Ulrik Doehn et al. MOLECULAR CELL
- Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma
- (2009) Lavanya H Palavalli et al. NATURE GENETICS
- Identification and Characterization of a General Nuclear Translocation Signal in Signaling Proteins
- (2008) Dana Chuderland et al. MOLECULAR CELL
- Sensing and Integration of Erk and PI3K Signals by Myc
- (2008) Tae Lee et al. PLoS Computational Biology
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