Prognostic impact and targeting of CRM1 in acute myeloid leukemia

Survivin is highly expressed in CD34+38- leukemic stem/progenitor cells and predicts poor clinical outcomes in AML

(2012) B. Z. Carter et al.   BLOOD

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

(2012) R. Lapalombella et al.   BLOOD

Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia

(2012) P. Ranganathan et al.   BLOOD

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

(2012) J Etchin et al.   LEUKEMIA

Molecular characterization ofde novoPhiladelphia chromosome-positive acute myeloid leukemia

(2012) Sergej Konoplev et al.   LEUKEMIA & LYMPHOMA

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Nuclear export of proteins and drug resistance in cancer

(2011) Joel G. Turner et al.   BIOCHEMICAL PHARMACOLOGY

Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia

(2011) S. M. Kornblau et al.   BLOOD

Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia

(2011) N Ånensen et al.   ONCOGENE

Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia

(2010) J. Long et al.   BLOOD

Analysis of the p53 and MDM-2 gene in acute myeloid leukemia

(2010) Barbara Seliger et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal

(2010) Z. Zhao et al.   GENES & DEVELOPMENT

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

EXPRESSION OF CRM1 IN HUMAN GLIOMAS AND ITS SIGNIFICANCE IN P27 EXPRESSION AND CLINICAL PROGNOSIS

(2009) Aiguo Shen et al.   NEUROSURGERY

The Isoforms of the p53 Protein

(2009) M. P. Khoury et al.   Cold Spring Harbor Perspectives in Biology

Functional proteomic profiling of AML predicts response and survival

(2008) S. M. Kornblau et al.   BLOOD

Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer

(2008) Aurelia Noske et al.   CANCER

The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation

(2008) Pauline J. van der Watt et al.   INTERNATIONAL JOURNAL OF CANCER

MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2

(2008) L Gu et al.   LEUKEMIA