KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells

Targeting the Nuclear Import Receptor Kpn 1 as an Anticancer Therapeutic

(2016) P. J. van der Watt et al.   MOLECULAR CANCER THERAPEUTICS

ER stress: Autophagy induction, inhibition and selection

(2015) Harun-Or Rashid et al.   Autophagy

Hyper-dependence of breast cancer cell types on the nuclear transporter Importin β1

(2015) Henna V. Kuusisto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Importin β1 mediates nuclear factor-κB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis

(2015) Wenqing Yan et al.   CELLULAR SIGNALLING

CHOP mediates XBP1S-induced renal mesangial cell necrosis following high glucose treatment

(2015) Decui Shao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Upregulation of nuclear transporter, Kpnβ1, contributes to accelerated cell proliferation- and cell adhesion-mediated drug resistance (CAM-DR) in diffuse large B-cell lymphoma

(2015) Song He et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

(2015) Shundong Cang et al.   Journal of Hematology & Oncology

Hsp90 inhibition induces both protein-specific and global changes in the ubiquitinome

(2015) Manfredo Quadroni et al.   Journal of Proteomics

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

(2015) Joel D. Leverson et al.   Science Translational Medicine

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

(2015) J D Leverson et al.   Cell Death & Disease

Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization

(2014) Anette Szczepny et al.   BIOCHEMICAL JOURNAL

Inhibition of the nuclear transporter, Kpnβ1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in cervical cancer cells

(2014) Liselotte Angus et al.   CARCINOGENESIS

The p53-induced factor Ei24 inhibits nuclear import through an importin β–binding–like domain

(2014) Kim G. Lieu et al.   JOURNAL OF CELL BIOLOGY

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Evaluation of the BH3-only Protein Puma as a Direct Bak Activator

(2013) Haiming Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Interaction of Bax and Bak Proteins with Bcl-2 Homology Domain 3 (BH3)-only Proteins in Living Cells Revealed by Fluorescence Complementation

(2013) Laura Vela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZFX regulates glioma cell proliferation and survival in vitro and in vivo

(2013) Zhichuan Zhu et al.   JOURNAL OF NEURO-ONCOLOGY

EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis

(2013) Pingyu Zhang et al.   JOURNAL OF PATHOLOGY

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

(2012) Guoliang Qing et al.   CANCER CELL

CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

(2012) Shuang Chen et al.   CANCER RESEARCH

Endoplasmic reticulum stress inhibits cell cycle progression via induction of p27 in melanoma cells

(2012) Chuanchun Han et al.   CELLULAR SIGNALLING

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Transient Aggregation of Ubiquitinated Proteins Is a Cytosolic Unfolded Protein Response to Inflammation and Endoplasmic Reticulum Stress

(2012) Xian-De Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores

(2012) Emanuele Roscioli et al.   JOURNAL OF CELL BIOLOGY

Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β

(2011) Jonathan F. Soderholm et al.   ACS Chemical Biology

Oxaliplatin Sensitizes Human Colon Cancer Cells to TRAIL Through JNK-Dependent Phosphorylation of Bcl-xL

(2011) Zineb El Fajoui et al.   GASTROENTEROLOGY

Importin β1 Protein-mediated Nuclear Localization of Death Receptor 5 (DR5) Limits DR5/Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-induced Cell Death of Human Tumor Cells

(2011) Yuko Kojima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of the STAT3 Transcription Factor: Nuclear Import Dependent on Ran and Importin-β1

(2011) Velasco Cimica et al.   PLoS One

Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat

(2010) Diego Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Perturbation of the Bcl-2 Network and an Induced Noxa/Bcl-xL Interaction Trigger Mitochondrial Dysfunction after DNA Damage

(2010) Hernando Lopez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Requirement for Lamin B Receptor and Its Regulation by Importin β and Phosphorylation in Nuclear Envelope Assembly during Mitotic Exit

(2010) Xuelong Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule assembly by the Apc protein is regulated by importin- --RanGTP

(2010) D. Dikovskaya et al.   JOURNAL OF CELL SCIENCE

Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

(2010) Michael H. A. Schmitz et al.   NATURE CELL BIOLOGY

Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors

(2009) J.-M. Mingot et al.   JOURNAL OF CELL SCIENCE

Rembrandt: Helping Personalized Medicine Become a Reality through Integrative Translational Research

(2009) S. Madhavan et al.   MOLECULAR CANCER RESEARCH

Enhanced ubiquitin-proteasome activity in calreticulin deficient cells: A compensatory mechanism for cell survival

(2008) Anton V. Uvarov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH