A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response

The Complex Mechanisms by Which Neurons Die Following DNA Damage in Neurodegenerative Diseases

(2022) Sina Shadfar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intricate coupling between the transactivation and basic-leucine zipper domains governs phosphorylation of transcription factor ATF4 by casein kinase 2

(2022) Steven Siang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATF4 promotes brain vascular smooth muscle cells proliferation, invasion and migration by targeting miR-552-SKI axis

(2022) Meina Feng et al.   PLoS One

Amino acid stress response genes promote L-asparaginase resistance in pediatric acute lymphoblastic leukemia

(2022) Daniel C. Ferguson et al.   Blood Advances

The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)

(2022) Zeenat Farooq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activating transcription factor 4 aggravates angiotensin II-induced cell dysfunction in human vascular aortic smooth muscle cells via transcriptionally activating fibroblast growth factor 21

(2022) Ke Tao et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review

(2022) Ruqin Zhou et al.   Frontiers in Neuroscience

Gsk-3-Mediated Proteasomal Degradation of ATF4 Is a Proapoptotic Mechanism in Mouse Pancreatic β-Cells

(2022) Yuko Nagao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain

(2021) Meng He et al.   Frontiers in Neuroscience

FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis

(2021) Liwei Lang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cooperation of ATF4 and CTCF promotes adipogenesis through transcriptional regulation

(2021) Yingchun Chen et al.   CELL BIOLOGY AND TOXICOLOGY

Pharmacological or TRIB3-Mediated Suppression of ATF4 Transcriptional Activity Promotes Hepatoma Cell Resistance to Proteasome Inhibitor Bortezomib

(2021) Tiit Örd et al.   Cancers

A Maternal Low-protein Diet during Gestation Induces Hepatic Autophagy-related Gene Expression in a Sex-specific Manner in Sprague-Dawley Rats

(2021) Mingzhu Cai et al.   BRITISH JOURNAL OF NUTRITION

ATF4-mediated GDF15 suppresses LPS-induced inflammation and MUC5AC in human nasal epithelial cells through the PI3K/Akt pathway

(2021) An Li et al.   LIFE SCIENCES

Targeting synaptic plasticity in schizophrenia: insights from genomic studies

(2021) Arne W. Mould et al.   TRENDS IN MOLECULAR MEDICINE

Olanzapine Induces Inflammation and Immune Response via Activating ER Stress in the Rat Prefrontal Cortex

(2021) Wen-ting Li et al.   Current Medical Science

PERK signaling activation restores nucleus pulposus degeneration by activating autophagy under hypoxia environment

(2021) H. Zhong et al.   OSTEOARTHRITIS AND CARTILAGE

High ATF4 Expression Is Associated With Poor Prognosis, Amino Acid Metabolism, and Autophagy in Gastric Cancer

(2021) Mingliang Wang et al.   Frontiers in Oncology

Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ

(2020) Scott M. Ebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

Ionizing Radiation Regulates Vascular Endothelial Growth Factor-A Transcription in Cultured Human Vascular Endothelial Cells Via the PERK/eIF2α/ATF4 Pathway

(2020) Eun Ju Kim et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4

(2020) Thomas D. Burton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A reference map of the human binary protein interactome

(2020) Katja Luck et al.   NATURE

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic and chemical interactions

(2020) Rose Oughtred et al.   PROTEIN SCIENCE

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains

(2020) Christian Haenig et al.   Cell Reports

A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation

(2020) Jonathan Poh et al.   Redox Biology

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes

(2019) Qian Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response

(2019) Lillian R. Kenner et al.   SCIENCE

Structural basis for eIF2B inhibition in integrated stress response

(2019) Kazuhiro Kashiwagi et al.   SCIENCE

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

(2019) Feven Tameire et al.   NATURE CELL BIOLOGY

Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate

(2019) Meng He et al.   PSYCHONEUROENDOCRINOLOGY

Structural basis for the inhibition of translation through eIF2α phosphorylation

(2019) Yuliya Gordiyenko et al.   Nature Communications

The structural basis of translational control by eIF2 phosphorylation

(2019) Tomas Adomavicius et al.   Nature Communications

Undercarboxylated osteocalcin downregulates pancreatic lipase expression in an ATF4-dependent manner in pancreatic acinar cells

(2019) Danbi Park et al.   BONE

Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing

(2019) Christof Niehrs et al.   TRENDS IN GENETICS

TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP–ATF response elements in the Fgf21 promoter

(2018) Tiit Örd et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Protodioscin Induces Apoptosis Through ROS-Mediated Endoplasmic Reticulum Stress via the JNK/p38 Activation Pathways in Human Cervical Cancer Cells

(2018) Chia-Liang Lin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Activating Transcription Factor 4 (ATF4) regulates neuronal activity by controlling GABABR trafficking

(2018) Carlo Corona et al.   JOURNAL OF NEUROSCIENCE

Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress

(2018) Ronald C. Wek   Cold Spring Harbor Perspectives in Biology

The Transcription Factor ATF4 Promotes Expression of Cell Stress Genes and Cardiomyocyte Death in a Cellular Model of Atrial Fibrillation

(2018) Johanna K. Freundt et al.   Biomed Research International

GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress

(2018) Yue Wang et al.   Redox Biology

A PDX1-ATF transcriptional complex governs β cell survival during stress

(2018) Christine A. Juliana et al.   Molecular Metabolism

Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress–Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer

(2018) Rozita Bagheri-Yarmand et al.   MOLECULAR CANCER RESEARCH

ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS

(2018) Fangfang Di et al.   Frontiers in Endocrinology

Silencing of both ATF4 and PERK inhibits cell cycle progression and promotes the apoptosis of differentiating chondrocytes

(2017) Zhimeng Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3β/β-catenin/cyclin D1 signaling pathway in ER-negative breast cancer

(2017) Song Gao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation

(2017) Andrew M. Bogorad et al.   NUCLEIC ACIDS RESEARCH

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

(2017) Inge M.N. Wortel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Neurodegeneration: Keeping ATF4 on a Tight Leash

(2017) Priyamvada M. Pitale et al.   Frontiers in Cellular Neuroscience

Combinatorial bZIP dimers display complex DNA-binding specificity landscapes

(2017) José A Rodríguez-Martínez et al.   eLife

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response

(2016) Sara K. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation

(2016) Keiji Uematsu et al.   JOURNAL OF CELL BIOLOGY

The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation

(2016) Jixiu Shan et al.   NUCLEIC ACIDS RESEARCH

The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress

(2016) Kamindla Rajesh et al.   Oncotarget

p58IPKis an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity

(2015) Anne Roobol et al.   BIOCHEMICAL JOURNAL

ChIP bias as a function of cross-linking time

(2015) Laura Baranello et al.   CHROMOSOME RESEARCH

The switch from ER stress-induced apoptosis to autophagy via ROS-mediated JNK/p62 signals: A survival mechanism in methotrexate-resistant choriocarcinoma cells

(2015) Yun Shen et al.   EXPERIMENTAL CELL RESEARCH

Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response

(2015) Sara K. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

(2015) Rebecca R. Crawford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Dual Kinase Function of the RET Proto-oncogene Negatively Regulates Activating Transcription Factor 4-mediated Apoptosis

(2015) Rozita Bagheri-Yarmand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4

(2015) Christopher J. Huggins et al.   MOLECULAR AND CELLULAR BIOLOGY

ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells

(2015) S. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Lower expression of activating transcription factors 3 and 4 correlates with shorter progression-free survival in multiple myeloma patients receiving bortezomib plus dexamethasone therapy

(2015) T Narita et al.   Blood Cancer Journal

Specific Downregulation of Hippocampal ATF4 Reveals a Necessary Role in Synaptic Plasticity and Memory

(2015) Silvia Pasini et al.   Cell Reports

ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis

(2015) Daniel M Cohen et al.   eLife

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

A Proteome-Scale Map of the Human Interactome Network

(2014) Thomas Rolland et al.   CELL

GABA receptors in brain development, function, and injury

(2014) Connie Wu et al.   METABOLIC BRAIN DISEASE

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Phosphoinositide 3-Kinases Upregulate System xc− via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

(2013) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation

(2013) M. D. Jennings et al.   GENES & DEVELOPMENT

CG methylated microarrays identify a novel methylated sequence bound by the CEBPB ATF4 heterodimer that is active in vivo

(2013) I. K. Mann et al.   GENOME RESEARCH

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases

(2013) Sandra Orchard et al.   NUCLEIC ACIDS RESEARCH

Networks of bZIP Protein-Protein Interactions Diversified Over a Billion Years of Evolution

(2013) A. W. Reinke et al.   SCIENCE

Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4

(2012) Chih-Kang Chiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

FGF19(fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress

(2012) Makoto Shimizu et al.   BIOCHEMICAL JOURNAL

Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response

(2012) Emmanuel Ampofo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway

(2012) Y. Wang et al.   CANCER RESEARCH

3,3′-Diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells

(2012) Seong-Ho Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Implication of eIF2α kinase GCN2 in induction of apoptosis and endoplasmic reticulum stress-responsive genes by sodium salicylate

(2012) Solange H.L. Gentz et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Gestational low protein diet selectively induces the amino acid response pathway target genes in the liver of offspring rats through transcription factor binding and histone modifications

(2011) Dan Zhou et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to EnhanceCHOPTranslation

(2011) Lakshmi Reddy Palam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress

(2011) Aiyuan Wang et al.   JOURNAL OF PATHOLOGY

Toward an understanding of the protein interaction network of the human liver

(2011) J. Wang et al.   Molecular Systems Biology

New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform

(2011) Yishay Shoval et al.   PLoS One

Quercetin Suppresses Cyclooxygenase-2 Expression and Angiogenesis through Inactivation of P300 Signaling

(2011) Xiangsheng Xiao et al.   PLoS One

UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression

(2010) Carla R. Bromati et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

(2010) Timothy Ravasi et al.   CELL

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

Characterization of hNek6 Interactome Reveals an Important Role for Its Short N-Terminal Domain and Colocalization with Proteins at the Centrosome

(2010) Gabriela Vaz Meirelles et al.   JOURNAL OF PROTEOME RESEARCH

A human MAP kinase interactome

(2010) Sourav Bandyopadhyay et al.   NATURE METHODS

Amino Acid Availability Controls TRB3 Transcription in Liver through the GCN2/eIF2α/ATF4 Pathway

(2010) Valérie Carraro et al.   PLoS One

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Identification of a Protein, G0S2, That Lacks Bcl-2 Homology Domains and Interacts with and Antagonizes Bcl-2

(2009) C. Welch et al.   CANCER RESEARCH

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes

(2009) Vionnie W.C. Yu et al.   GENE EXPRESSION PATTERNS

An Upstream Open Reading Frame Regulates Translation of GADD34 during Cellular Stresses That Induce eIF2α Phosphorylation

(2009) Yun-Young Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PUMA, a potent killer with or without p53

(2009) J Yu et al.   ONCOGENE

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

(2009) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway

(2008) Altin Gjymishka et al.   BIOCHEMICAL JOURNAL

Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection

(2008) Jorja Degrado-Warren et al.   BIOTECHNIQUES

ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response

(2008) O. V. Oskolkova et al.   BLOOD

C/EBP Homology Protein (CHOP) Interacts with Activating Transcription Factor 4 (ATF4) and Negatively Regulates the Stress-dependent Induction of the Asparagine Synthetase Gene

(2008) Nan Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of eIF2 DirectsATF5Translational Control in Response to Diverse Stress Conditions

(2008) Donghui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Novel Protein MICS1 that is Involved in Maintenance of Mitochondrial Morphology and Apoptotic Release of Cytochrome c

(2008) Toshihiko Oka et al.   MOLECULAR BIOLOGY OF THE CELL

CCAAT/Enhancer-binding Protein β Promotes Osteoblast Differentiation by Enhancing Runx2 Activity with ATF4

(2008) Hiroyuki Tominaga et al.   MOLECULAR BIOLOGY OF THE CELL

Importin-mediated retrograde transport of CREB2 from distal processes to the nucleus in neurons

(2008) K.-O. Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activating transcription factor 4

(2007) Kurosh Ameri et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY