标题
Structural basis for eIF2B inhibition in integrated stress response
作者
关键词
-
出版物
SCIENCE
Volume 364, Issue 6439, Pages 495-499
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2019-05-03
DOI
10.1126/science.aaw4104
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- eIF2B Mechanisms of Action and Regulation: A Thermodynamic View
- (2018) Andrew M. Bogorad et al. BIOCHEMISTRY
- Structure of a human cap-dependent 48S translation pre-initiation complex
- (2018) Boris Eliseev et al. NUCLEIC ACIDS RESEARCH
- Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B
- (2018) Alisa F. Zyryanova et al. SCIENCE
- Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule
- (2018) Jordan C. Tsai et al. SCIENCE
- The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes
- (2018) Yao Liang Wong et al. eLife
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation
- (2017) Andrew M. Bogorad et al. NUCLEIC ACIDS RESEARCH
- Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury
- (2017) Austin Chou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes
- (2017) Martin D Jennings et al. eLife
- The integrated stress response
- (2016) Karolina Pakos‐Zebrucka et al. EMBO REPORTS
- Crystal structure of eukaryotic translation initiation factor 2B
- (2016) Kazuhiro Kashiwagi et al. NATURE
- Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2
- (2016) Dari Kimanius et al. eLife
- eIF2B: recent structural and functional insights into a key regulator of translation
- (2015) N. C. Wortham et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy
- (2015) Benjamin A Barad et al. NATURE METHODS
- Mutations in a translation initiation factor identify the target of a memory-enhancing compound
- (2015) Y. Sekine et al. SCIENCE
- Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity
- (2015) M Halliday et al. Cell Death & Disease
- Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response
- (2015) Carmela Sidrauski et al. eLife
- eIF2 interactions with initiator tRNA and eIF2B are regulated by post-translational modifications and conformational dynamics
- (2015) Victoria Beilsten-Edmands et al. Cell Discovery
- Translation Initiation Requires Cell Division Cycle 123 (Cdc123) to Facilitate Biogenesis of the Eukaryotic Initiation Factor 2 (eIF2)
- (2013) Angelika F. Perzlmaier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Quantifying the local resolution of cryo-EM density maps
- (2013) Alp Kucukelbir et al. NATURE METHODS
- Gene Expression Regulation by Upstream Open Reading Frames and Human Disease
- (2013) Cristina Barbosa et al. PLoS Genetics
- Structure of the ternary initiation complex aIF2–GDPNP–methionylated initiator tRNA
- (2012) Emmanuelle Schmitt et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Linking Crystallographic Model and Data Quality
- (2012) P. A. Karplus et al. SCIENCE
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Leukoencephalopathy With Vanishing White Matter: A Review
- (2010) Marianna Bugiani et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- The /Gcd7 Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2B), a Guanine Nucleotide Exchange Factor, Is Crucial for Binding eIF2 In Vivo
- (2010) K. Dev et al. MOLECULAR AND CELLULAR BIOLOGY
- Crystal structure of the C-terminal domain of the ɛ subunit of human translation initiation factor eIF2B
- (2010) Jia Wei et al. Protein & Cell
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Eukaryotic and archaeal translation initiation factor 2: A heterotrimeric tRNA carrier
- (2009) Emmanuelle Schmitt et al. FEBS LETTERS
- Clues to the mechanism of action of eIF2B, the guanine-nucleotide-exchange factor for translation initiation
- (2008) Sarah S. Mohammad-Qureshi et al. BIOCHEMICAL SOCIETY TRANSACTIONS
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